A5082317480- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Uterine Myomas and Treatments
- Histone Deacetylase Inhibitors Research
- Gynecological conditions and treatments
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Reproductive System and Pregnancy
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Ovarian cancer diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Immunology Research
- Endometriosis Research and Treatment
- SARS-CoV-2 and COVID-19 Research
The University of Texas Health Science Center at San Antonio
2024-2025
The University of Texas Health Science Center at Houston
2024-2025
Texas Biomedical Research Institute
2024
Yazd University
2022-2023
Bromodomain-containing proteins (BRDs) are involved in many biological processes, most notably epigenetic regulation of transcription, and BRD dysfunction has been linked to diseases, including tumorigenesis. However, the role BRDs pathogenesis uterine fibroids (UFs) is entirely unknown. The present study aimed determine expression pattern BRD9 UFs matched myometrium further assess impact a inhibitor on UF phenotype epigenetic/epitranscriptomic changes. Our studies demonstrated that levels...
Uterine fibroids (UFs) are the most common non-cutaneous tumors in women worldwide. UFs arise from genetic alterations myometrial stem cells (MM SCs) that trigger their transformation into tumor-initiating (UF SCs). Mutations RNA polymerase II Mediator subunit MED12 dominant drivers of UFs, accounting for 70% these clinically significant lesions. Biochemically, UF driver mutations disrupt CDK8/19 kinase activity Mediator, but how disruption triggers MM SC remains unknown. Here, we show...
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma associated with poor prognosis, high rates recurrence, and metastasis. There currently limited information about uLMS molecular mechanisms origin development. Bromodomain (BRD)-containing proteins are involved in many biological processes, notably epigenetic regulation transcription, BRD protein dysfunction has been linked to diseases including tumorigenesis. However, role pathogenesis unknown. Here, we show for first...
Uterine leiomyosarcoma (uLMS) is the most frequent subtype of uterine sarcoma that presents a poor prognosis, high rates recurrence, and metastasis. Currently, molecular mechanism origin development uLMS unknown. Class I histone deacetylases (including HDAC1, 2, 3, 8) are one major classes HDAC family catalyze removal acetyl groups from lysine residues in histones cellular proteins. HDACs exhibit distinct subcellular expression patterns involved many biological processes diseases through...
The zinc finger antiviral protein (ZAP) is known to restrict viral replication by binding the CpG rich regions of RNA, and subsequently inducing RNA degradation. This enzyme has recently been shown be capable restricting SARS-CoV-2. These data have led hypothesis that low abundance in SARS-CoV-2 genome due an evolutionary pressure exerted host ZAP. To investigate this hypothesis, we performed a detailed analysis many coronavirus sequences ZAP preference data. Our analyses showed neither...
Bromodomain (BRD)-containing proteins are involved in many biological processes, most notably epigenetic regulation of transcription, and BRD protein dysfunction has been linked to diseases, including tumorigenesis. However, the role pathogenesis uterine fibroids (UFs) is entirely unknown. The present study aimed determine expression pattern BRD9 UFs matching myometrium further assess impact inhibitors on UF phenotype epigenetic/epitranscriptomic changes. Our studies demonstrated that levels...
Abstract The National Cancer Institute has designated several viruses such as EBV, HBV, HCV, HIV, HPV, and HTLV agents that either cause cancer or increase the risk of developing cancer. However, extensive analyses tumor genome transcriptome datasets have identified numerous additional virus types, functional implications which remain largely unknown. Viral infection often dysregulates unique molecular processes within cells alters composition immune in microenvironment. For instance,...
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, associated with poor prognosis, high rates recurrence, and metastasis. Currently, molecular mechanism origin development uLMS limited. Bromodomain extra-terminal (BET) proteins are involved in both physiological pathological events. However, role BET pathogenesis unknown. Here, we show for first time that protein family members, BRD2, BRD3, BRD4, aberrantly overexpressed tissues compared to myometrium, a significant...
<title>Abstract</title> Uterine fibroids (UFs) are the most common non-cutaneous tumors in women worldwide. UFs arise from genetic alterations myometrial stem cells (MM SCs) that trigger their transformation into tumor initiating (UF SCs). Mutations RNA polymerase II Mediator subunit MED12 dominant drivers of UFs, accounting for 70% these clinically significant lesions. Biochemically, UF driver mutations disrupt CDK8/19 kinase activity Mediator, but how disruption triggers MM SC remains...
Abstract DNA of many breast tumors is barraged by C-to-T/G mutations within TCW (W:T,A). These are attributed to the aberrant expression and activity APOBEC3 enzymes. They have been shown account for driver in genes such as PIK3CA, ERBB2, PPP2R1A, however their precise source also roles tumor development, evolution, patient survival debated. Currently, quantification changes cells confounded ubiquitous these enzymes immune infiltrating cells. In this study, we used a novel quantitative...
Abstract DNA of many tumors is barraged by C-to-T/G mutations within TCW (W:T,A). These are attributed to the aberrant expression and activity APOBEC3 enzymes. They have been shown account for driver in genes such as PIK3CA, ERBB2, PPP2R1A, however their precise source also roles tumor development, evolution, patient survival debated. Currently, quantification changes cells confounded ubiquitous these enzymes infiltrating immune cells. In this study, we used quantitative biology approaches...