A5023290652- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Protein Structure and Dynamics
- Chemical Synthesis and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Click Chemistry and Applications
- Molecular Sensors and Ion Detection
- Enzyme Structure and Function
- Metal complexes synthesis and properties
- Advanced Nanomaterials in Catalysis
- Lanthanide and Transition Metal Complexes
Stanford University
2024-2025
Pulse Biosciences (United States)
2024-2025
SLAC National Accelerator Laboratory
2024-2025
Enzymes exist in ensembles of states that encode the energetics underlying their catalysis. Conformational built from 1231 structures 17 serine proteases revealed atomic-level changes across reaction states. By comparing enzymatic and solution reaction, we identified molecular features provide catalysis quantified energetic contributions to Serine precisely position reactants destabilized conformers, creating a downhill gradient selectively favors motions required for while limiting...
Abstract Enzymes exist in ensembles of states that encode the energetics underlying their catalysis. Conformational built from 1231 structures 17 serine proteases reveal atomic-level changes across reaction states, identify molecular features provide catalysis, and quantify energetic contributions to These enzymes precisely position reactants destabilized conformers, creating a downhill gradient selectively favors motions required for while limiting off-pathway conformational states. A local...