Antimalarial drug resistance has thrown a spanner in the works of malaria elimination. New drugs are required for ancillary support existing control efforts. Plasmodium falciparum requires host glucose survival and proliferation. On this basis, P . hexose transporter 1 ( Pf HT1) protein involved permeation is considered potential target. In study, we tested antimalarial activity some compounds against HT1 using computational techniques. We performed high throughput virtual screening 21,352...

Resistance monitoring is essential in ensuring the success of insecticide based vector control programmes. This study was carried out to assess susceptibility status urban populations Anopheles gambiae carbamate being considered for mosquito previously reported be resistant DDT and permethrin. Two – three day old adult female mosquitoes reared from larval collections 11 sites Local Government Areas Lagos were exposed test papers impregnated with 4%, deltamethrin 0.05% propoxur 0.1%...

Human activities can have dramatic effects on animal populations around urban areas with heavy metal contamination being a primary cause of harm. Amphibians, as residents aquatic systems and their semi-permeable skin are especially susceptible to contamination. To better understand the effect metals Wild African Tiger frogs (Hoplobatrachus occipitalis) resulting production oxidative stress enzymes, concentrations metals, cadmium (Cd), copper (Cu), iron (Fe), zinc (Zn), lead (Pb) nickel (Ni)...

Sickle cell disease (SCD) poses a significant health challenge and therapeutic approaches often target fetal hemoglobin (HbF) to ameliorate symptoms. Hydroxyurea, current option for SCD, has shown efficacy in increasing HbF levels. However, concerns about myelosuppression thrombocytopenia necessitate the exploration of alternative compounds. Heme-regulated inhibitor (HRI) presents promising pharmacological intervention SCD due its association with modulation. This study screened compounds...

Abstract Background Asymptomatic malaria parasites are significant sources of infections for onward transmission. Conventional tools diagnosis such as microscopy and rapid diagnostic test kits (RDT) have relatively low sensitivity, hence the need alternative active screening low-density infections. Methods This study tested var acidic terminal sequence-based ( ATS) quantitative polymerase chain reaction (qPCR) asymptomatic Plasmodium falciparum among dwellers a sub-urban community in Lagos,...

To analyse the genetic diversity of Plasmodium falciparum (P. falciparum) using msp-1 and msp-2 as antigenic markers.Parasite DNA was extracted from 100 blood samples collected P. falciparum-positive patients confirmed by microscopy, followed PCR-genotyping targeting (block2) (block 3) allelic families.All families (K1, MAD20 R033) (FC27 3D7) locus were observed. Results revealed that K1 (60/100) most predominant genotype family genotypes (50/100) R033 (45/100). In locus, FC27 (62/100)...

Urinary schistosomiasis is endemic in many rural communities of Nigeria and school aged children are mostly affected. A cross-sectional study was carried out to assess the prevalence intensity urinary infection among 251 two Ovia South West LGA Edo State, Nigeria, as well their knowledge on control/elimination measures. Urine samples were collected examined by microscopy using filtration technique. In addition, a questionnaire survey conducted school-aged health care providers, probing...

Abstract The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after introduction artemisinin-based combination therapies (ACTs). However, emergence artemisinin (ART) resistance in South-East Asia and reports delayed parasite sensitivity to ACTs African parasites signal an imminent treatment failure. Monitoring prevalence mutations associated with populations is required stop its tracks. Plasmodium falciparum...

Abstract Objectives The study evaluated sub-microscopic malaria infections in pregnancy using two Rapid Diagnostic Tests (mRDTs), microscopy and RT-PCR characterized Plasmodium falciparum dihydrofolate reductase ( Pf dhfr) dihydropteroate synthase dhps) drug resistant markers positive samples. Methods This was a cross sectional survey of 121 pregnant women. Participants were finger pricked, blood drops collected for rapid diagnosis with P. histidine-rich protein 11 diagnostic test kit the...

Genetic diversity studies provide evidence of Plasmodium falciparum differentiation that could affect fitness and adaptation to drugs target antigens for vaccine development. This study describes the genetic structure P. populations in urban rural sites from southwestern Nigeria.Ten neutral microsatellite loci were genotyped 196 infections three localities: Aramoko-Ekiti, a community; Lekki, an location Badagry, peri-urban border settlement. Analysis was performed on diversity, linkage...

Mosquito coil is a vector control option used to prevent malaria in low income counties, while some studies have addressed this issue, additional reseach required increase knowledge on the adverse health effects caused by prolonged use of coils. In study we investigated toxicological fumes from two locally manufactured mosquito insecticides (with pyrethroids: transfluthrin and d-allethrin as active ingredients) male albino rats. For this, recorded haematological biochemical indices, made...

Lime extracts of powdered combination seeds Picralima nitida, stem bark Alstonia boonei and leaves Gongronema latifolium is a common remedy used in the treatment malaria South Western Nigeria.To determine antiplasmodial activities combined herbal its impact on haematological, hepatological renological parameters mice.The 4-day suppressive curative tests were to assess extract mice infected with chloroquine-sensitive Plasmodium berghei at concentration 200mg/kg, 400mg/kg 800mg/kg body weight....

Urban ecosystems are often characterized by the receipt of pollutants, especially heavy metals from diverse anthropogenic activities.To better understand distribution (Cd, Cu, Pb, Mn and Zn), Austroaeschna inermis five different sites (Unilag, Mile 12, Olushosun Dump site, Imoshe Badagry) in Lagos, sediments respective were assessed.This was followed assessment lipid peroxidation product; Malondialdehyde (MDA) antioxidative stress enzymes; superoxide dismutase (SOD), catalase (CAT),...

Malaria in pregnancy is one of the major causes mater nal morbidity and mortality as well poor outcomes. We studied knowledge, attitude practices pregnant women on malaria prevention, assessed their knowledge sulfadoxine-pyrimethamine (SP) for intermittent preventive therapy (IPTp-SP), used outcomes to create awareness prevention with IPTp-SP.

Abstract Background Combination of different antimalarials has become the popular method care for malaria morbidity in conventional and traditional treatment approaches due to need increase efficacy reduce selection drug resistance. A worrisome concern is critical gaps with regards information available on antimalarial herbal cocktails. This study presents cocktail remedies ethnomedicinal Oyo Ogun states, South West Nigeria. Ethnobotanical indigenous used combination was collected from...

Mass drug administration against malaria and parasitic worm co-infections is capable of increasing health risk. This study investigated the hepatotoxicity, genotoxicity oxidative stress induced by combinations Arthemether-Lumefantrine (A-L) with Albendazole (ABZ) Ivermectin (IVR) treatments in rats. 65 rats equally distributed into 13 groups were orally gavaged human therapeutic doses (×1.0), half (×0.5) twice (×2.0) these drugs per body weights. Blood, liver bone marrow cells analyzed for...

Plasmodium vivax and P. falciparum are the most important human malaria species. is considered virulent widespread species in sub-Saharan Africa. Hence, control efforts have focused on reducing morbidity mortality associated with malaria. However, improved diagnostics, there more evidence of high burden As capable dormancy liver, it suspected that artemisinin-based combination treatment widely use across Africa to combat may be favouring adaptive selection for vivax. Additionally, a better...

Abstract Objective Nigeria bears 25% of global malaria burden despite concerted efforts towards its control and elimination. The emergence drug resistance to first line drugs, artemisinin combination therapies (ACTs), indicates an urgent need for continuous molecular surveillance especially in high countries where interventions are heavily relied on. This study describes mutations Plasmodium falciparum genes associated with malaria; Pfk1 3, Pfmdr1 , PfATPase6 Pfcrt isolates obtained from 83...

Abstract Background Aedes aegypti transmits several arboviral diseases of global public health threat such as dengue, zika, and yellow fever. Recently, a series fever outbreaks have been reported in different parts the country. Globally, control mosquito-borne has relied heavily on insecticides based vector efforts. Therefore, we assessed susceptibility status to three classes WHO approved evaluated importance detoxifying enzymes resistance collected from Lagos State, Nigeria. immature...

Abstract The outbreak of yellow fever virus transmitted by Aedes aegypti has been major concern in Nigeria, this mosquito also transmits several other arboviruses globally. control many vectors mosquito-borne diseases relies heavily on the use insecticides. Therefore, constant monitoring insecticide resistance status and associated mechanisms is crucial within local population. Here, we determined profile adult Ae. from Majidun Oke Ota communities, Ikorodu Local Government Area Lagos State,...

The decline in the efficacy of artemisinin-based combination treatment (ACT) some endemic regions threatens progress towards global elimination malaria. Molecular surveillance drug resistance malaria-endemic is vital to detect emergence and spread mutant strains. We observed 89 malaria patients for artemether-lumefantrine uncomplicated Plasmodium falciparum infections Lagos, Nigeria determined prevalence resistant strains population. Parasite clearance rates were by microscopy highly...