A5103140318- Immunotherapy and Immune Responses
- Salivary Gland Disorders and Functions
- Oral microbiology and periodontitis research
- NF-κB Signaling Pathways
- Bone Metabolism and Diseases
- Nutrition and Health in Aging
- Cell Adhesion Molecules Research
- Endodontics and Root Canal Treatments
- Muscle Physiology and Disorders
- Infant Nutrition and Health
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Gut microbiota and health
- Dental Implant Techniques and Outcomes
- Scientific and Engineering Research Topics
- Cancer Immunotherapy and Biomarkers
- Hedgehog Signaling Pathway Studies
- Exercise and Physiological Responses
Medical University of South Carolina
2024
Hebrew University of Jerusalem
2018-2022
Hadassah Medical Center
2018
Mucosal Langerhans cells (LCs) originate from pre–dendritic and monocytes. However, the mechanisms involved in their situ development remain unclear. Here, we demonstrate that differentiation of murine mucosal LCs is a two-step process. In lamina propria, signaling via BMP7-ALK3 promotes translocation LC precursors to epithelium. Within epithelium, TGF-β1 finalizes differentiation, ALK5 crucial this Moreover, local microbiota has major impact on LCs, whereas turn maintain homeostasis prevent...
Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation and its causality to by exploring skeletal muscle, whose atrophy strongly poor outcomes. Using multiple mouse models patient samples, we show cachectic muscle marked enhanced innate immunity. Nuclear factor κB (NF-κB) activity in cells, including satellite...
Sustained mechanical forces applied to tissue are known shape local immunity. In the oral mucosa, stress, either naturally induced by masticatory or externally via loading during orthodontic tooth movement (OTM), is translated, in part, T cells alveolar bone resorption. Nevertheless, despite being considered critical for OTM, depletion of CD4+ and CD8+ reported have no impact on movement, thus questioning function αβT OTM-associated To further address role we first characterized leukocytes...
Significance Oral cancer is often diagnosed at late stages, resulting in a poor prognosis of this disease. Understanding early carcinogenic events taking place during the development oral is, therefore, an important unmet clinical need. This study identifies anticancer protective role Langerhans cells (LCs), principal mononuclear phagocyte involved immunosurveillance epithelium. Continuous exposure to carcinogen 4NQO hampers local differentiation LCs, while other phagocytes and T with...
Peri-implantitis is a destructive inflammatory process affecting tissues surrounding dental implants and it considered new global health concern. Human studies have suggested that the frequencies of Langerhans cells (LCs), main antigen presenting (APCs) oral epithelium, are dysregulated around implants. Since LCs play role in regulating mucosal homeostasis, we studied impact titanium on LC differentiation using novel murine model. We demonstrate whereas percentage precursors (CD11c+MHCII+)...
Oral mucosal homeostasis is achieved by complex immunologic mechanisms, orchestrating host immunity to adapt the physiologic functions of various specialized niches in oral cavity. Dental implants introduce a novel niche immune system deal with. Nevertheless, mechanisms engaged toward and whether they have broader effects are not well defined. Using murine model, we found an accumulation neutrophils RANKL-expressing T B lymphocytes implant-surrounding mucosa, accompanied local bone loss....
Significance Langerhans cells (LCs) are the exclusive antigen-presenting of epidermis, capable mounting immunity and tolerance. LCs maintain themselves locally by self-renewing throughout life, a process that is regulated both keratinocytes. Nevertheless, mechanisms underlying this not clearly understood. Using targeted genetic ablation, we demonstrate lack protein S (PROS1) in keratinocytes, but LCs, results reduced numbers terminally developed LCs. This due to increased apoptosis...