A5033637525- Cancer-related molecular mechanisms research
- Pituitary Gland Disorders and Treatments
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- RNA regulation and disease
- RNA Research and Splicing
- Circular RNAs in diseases
- Composite Material Mechanics
- Natural product bioactivities and synthesis
- Biological Stains and Phytochemicals
- RNA modifications and cancer
- Topology Optimization in Engineering
- interferon and immune responses
- Numerical methods in engineering
- TGF-β signaling in diseases
National University of Singapore
2023
Dalian Medical University
2017-2019
Second Affiliated Hospital of Dalian Medical University
2017-2019
ShenZhen People’s Hospital
2019
Long non-coding RNAs (lncRNAs) function as oncogenes or tumor suppressors, and are involved in mediating tumorigenesis resistance to chemotherapy by altering the expression of genes at various levels. Accumulating evidence suggests that maternally expressed gene 3 (MEG3) lncRNA serves an important role a number cancers. However, its functional cisplatin‑induced apoptosis glioma cells is unknown. To investigate MEG3, mRNA levels MEG3 under cisplatin treatment were investigated reverse...
The laminin subunit alpha 2 (LAMA2) gene encodes an chain, which constitutes one of the subunits (merosin) and 4 (s-merosin). In current study, we investigated relationship between LAMA2 promoter methylation status invasiveness clinically nonfunctioning pituitary adenomas (PitNETs). Specimens from patients with PitNET were classified into three groups according to preoperative computed tomography (CT)/magnetic resonance imaging findings: a normal group ( n = 6), non-invasive 11) invasive 6)....
Abstract Isoalantolactone (IATL), a sesquiterpene lactone compound, possesses many pharmacological and biological activities, but its role in glioblastoma (GBM) treatment is still unknown. The aim of the current study was to investigate antiglioma effects IATL explore underlying molecular mechanisms. In study, functions were examined by MTT, cell migration, colony formation, apoptosis assays. Confocal immunofluorescence techniques, chromatin immunoprecipitation, pull‐down assays used precise...
The proneural (PN) and mesenchymal (MES) subtypes of glioblastoma multiforme (GBM) are robust generally consistent with classification schemes. GBMs in the MES subclass predominantly primary tumors that, compared to PN tumors, exhibit a worse prognosis; thus, understanding mechanism differentiation may be great benefit for treatment GBM. NF-κB signaling is critically important GBM, activation could induce transdifferentiation which warrants additional research. NUDT21 newly discovered...
Abstract The FE computational homogenization method is a predictive multi‐scale without the need for constitutive assumptions and/or potential function postulates at macro engineering scale. Instead, effective micro‐structural responses are extracted directly from representative volume element (RVE) underlying each point. However, still computationally too expensive most practical uses, since micro‐macro coupling done loading step/iteration entire domain. To this end, machine learning has...