A5081628927- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor materials and devices
- Silicon Carbide Semiconductor Technologies
- Ubiquitin and proteasome pathways
- GaN-based semiconductor devices and materials
- Radio Frequency Integrated Circuit Design
- Salivary Gland Disorders and Functions
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Muscle Physiology and Disorders
- Peptidase Inhibition and Analysis
- Integrated Circuits and Semiconductor Failure Analysis
- Pluripotent Stem Cells Research
- Autoimmune Neurological Disorders and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Protein Degradation and Inhibitors
- Muscle and Compartmental Disorders
- Semiconductor materials and interfaces
- Genetics and Neurodevelopmental Disorders
- Autophagy in Disease and Therapy
- Protein Tyrosine Phosphatases
- Thallium and Germanium Studies
- Infectious Encephalopathies and Encephalitis
- Diabetes and associated disorders
- RNA modifications and cancer
Kyoto University
1998-2024
Japanese Red Cross Society Wakayama Medical Center
2021
Kyoto University Hospital
2020-2021
Osaka Nishi Clinic
2021
Sunagawa City Medical Center
2021
Kyoto City Hospital
2017
Kitano Hospital
2016-2017
Shibaura Institute of Technology
1989-2005
National Cerebral and Cardiovascular Center
1998
Toshiba (Japan)
1994
It is not known whether autonomic neuropathy a feature of Sjögren's syndrome (SS) or it related to circulating antiganglionic acetylcholine receptor (gAChR) antibodies. The goal the present study was investigate dysfunction in patients with SS and associations between dysfunction, anti-gAChR antibodies, clinical features SS.(1) first observational tested for presence gAChR antibodies serum samples from 39 (absent information regarding symptoms) healthy volunteers. (2) In second study,...
Drain-current transients of GaAs MESFET's with deep donors "EL2" in the semi-insulating substrate are simulated range t=10/sup -13/ to 10/sup 2/ s. It is shown that drain step responses, there exists a "quasi-steady state" where do not respond voltage change and currents become constant temporarily. The begin decrease or increase gradually when capture emit electrons, reaching real steady-state values. I-V curves quite different between steady state. Therefore, can be causes drain-current...
Linear ubiquitin chains, which are generated specifically by the linear assembly complex (LUBAC) ligase, play crucial roles in immune signaling, including NF-κB activation. LUBAC comprises catalytic large isoform of heme-oxidized iron regulatory protein 2 ligase 1 (HOIL-1L) interacting (HOIP), accessory HOIL-1L, and SHANK-associated RH domain-interacting (SHARPIN). Deletion activity an LUBAC, augments functions enhancing LUBAC-mediated ubiquitination, is catalyzed HOIP. Here, we show that...
Linear ubiquitin chains play pivotal roles in immune signaling by augmenting NF‐κB activation and suppressing programmed cell death induced various stimuli. A20‐binding inhibitor of 1 (ABIN1) binds to linear attenuates induction. Although interactions with are thought a role ABIN1‐mediated suppression death, the underlying molecular mechanisms remain unclear. Here, we show that upon stimulation Toll‐like receptor (TLR) ligands, ABIN1 is phosphorylated on Ser 83 functions as selective...
We herein report a case of capsular warning syndrome (CWS) that was successfully treated with recombinant tissue plasminogen activator (rt-PA). A 70-year-old woman had repeated stereotyped transient ischemic attacks (TIAs) right hemiparesis and dysarthria. After hospitalization, argatroban, aspirin, cilostazol were started but ineffective. Thirteen hours after the first episode TIAs, severe symptoms occurred. Magnetic resonance imaging showed acute infarctions in internal capsule to corona...
A numerical analysis of GaAs MESFETs with a p-buffer layer on semi-insulating substrate is performed in which impurity compensation by traps the considered. It shown that use thick results lower device current due to formation steep barrier at channel-substrate interface. also higher trap and acceptor densities substrate, drain reduced decrease current. This occurs because negative-space-charge formed substrate. demonstrated when fully depleted, its acceptors play same electrical role as...
Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is a genetic disorder of fatty acid beta oxidation that caused by defect in ACADVL, which encodes VLCAD. The clinical presentation VLCAD heterogeneous, and either delayed diagnosis or misdiagnosis may sometimes occur. We herein describe difficult-to-diagnose case the muscle form adult-onset with compound heterozygous ACADVL mutations including c.790A>G (p.K264E) c.1246G>A (p.A416T).
Current-voltage characteristics of GaAs MESFETs (with p-butter layers) on semi-insulating substrates compensated by deep levels are simulated two-carrier and one-carrier models. For a thicker p-buffer layer or for higher acceptor density in the substrate, drain current becomes lower because substrate is reduced. The model also gives reasonable results case with hole-trap substrate. Small-signal parameters various types simulated. densities substrates, reduced, both transconductance cutoff...
Transient splenial lesion (TSL) of the corpus callosum is associated with various disorders, including encephalitis, seizure and metabolic disturbances (1).We herein report a patient showing TSL after switching antiepileptic medications.A 46-year-old woman epilepsy had been taking car-bamazepine for decades.Asymptomatic hyponatremia (125 mEq/L) was detected, carbamazepine switched to zonisamide.Three days later, she complained anorexia, fatigue polyuria, although resolved (141...
Abstract HOIL-1L deficiency was recently reported to be one of the causes myopathy and dilated cardiomyopathy (DCM). However, mechanisms by which DCM develop have not been clearly elucidated. Here, we sought elucidate these using murine myoblast cell line C2C12 disease-specific human induced pluripotent stem cells (hiPSCs). Myotubes differentiated from HOIL-1L-KO exhibited deteriorated differentiation mitotic accumulation. CMs patient-derived hiPSCs had an abnormal morphology with a larger...
A 60-year-old man presented with muscle stiffness. He had tended to fall since childhood. His parents were first cousins, and his relatives no symptoms. Examination showed myotonia in ocular, hand, limb muscles, followed by improvement repeated activity (warm-up phenomenon; Video 1). Cold exposure did not aggravate myotonia. lower legs hypertrophy. Genetic tests a homozygous p.M560T mutation the CLCN1 gene, which encodes skeletal chloride channel 1, consistent autosomal recessive congenita...
Abstract HOIL-1L deficiency was recently reported to be one of the causes myopathy and dilated cardiomyopathy (DCM). However, mechanisms by which DCM develop have not been clearly elucidated. Here, we sought elucidate these using murine myoblast cell line C2C12 disease-specific human induced pluripotent stem cells (hiPSCs). Myotubes were differentiated from control HOIL-1L-KO cells. Cardiomyocytes (CMs) patient-derived hiPSCs. We investigated impact on differentiation myotubes CMs. exhibited...
Drain-current transient of GaAs MESFETs are simulated in the range 10/sup -13/ to 2/ s. The currents become constant temporarily at round t equivalent -11/ s, but begin decrease or increase after some periods, reaching real steady-state values. slow transients attributed trapping and detrapping by deep levels substrate. Effects introducing a p-buffer layer on drain-current drifts, small-signal parameters also studied. It is shown that use low acceptor-density semi-insulating substrate...