A5038092134- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- High-Temperature Coating Behaviors
- High Entropy Alloys Studies
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Surgical Treatments
- Additive Manufacturing Materials and Processes
- Cancer Genomics and Diagnostics
- Intermetallics and Advanced Alloy Properties
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Neutropenia and Cancer Infections
- Particle accelerators and beam dynamics
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Patient Safety and Medication Errors
- Gastric Cancer Management and Outcomes
- Particle Accelerators and Free-Electron Lasers
- Diversity and Career in Medicine
- Electronic Health Records Systems
- Plant Surface Properties and Treatments
- Interprofessional Education and Collaboration
- Cancer survivorship and care
- Innovation Policy and R&D
- Psychiatric care and mental health services
Illinois Institute of Technology
2017-2024
Western University
2017-2024
George Washington University
2020-2024
University of California, Irvine
2024
Johns Hopkins University
2005-2022
George Washington University Hospital
2020-2021
Washington University Medical Center
2021
21st Century Oncology (United States)
2017-2019
Health Sciences Centre
2018
University of Ottawa
2018
Purpose Epidermal growth factor receptor/human epidermal receptor 1 (EGFR/HER1) and ligand expression is frequently seen in hepatocellular cancers (HCCs). Erlotinib (Tarceva, OSI-774; OSI Pharmaceuticals, Melville, NY) a tyrosine kinase inhibitor with specificity for the EGFR/HER1. Methods The primary objective of this study was to determine proportion patients advanced HCC who were progression-free at 6 months. Patients either unresectable or metastatic disease studied. Only one prior...
Epidermal growth factor receptor/human epidermal receptor 1 and ligand expression is common in biliary cancers (BILI) may be associated with worse outcome. The primary objective of this study was to determine the proportion patients advanced BILI who were progression-free at 6 months.Patients either unresectable or metastatic disease studied. Only one prior systemic locoregional therapy allowed. Erlotinib administered continuously a dose 150 mg per day orally.Forty-two enrolled. median age...
Abstract Severe distortion is one of the four core effects in single‐phase high‐entropy alloys (HEAs) and contributes significantly to yield strength. However, connection between atomic‐scale lattice macro‐scale mechanical properties through experimental verification has yet be fully achieved, owing two critical challenges: 1) difficulty development homogeneous solid‐solution HEAs 2) ambiguity describing related measurements calculations. A body‐centered‐cubic (BCC) refractory HEA,...
The present work discovers the unique deformation behavior of a refractory high-entropy alloy at elevated temperatures.
Drug resistance represents a major obstacle to successful cancer chemotherapy. However, the specific biochemical mechanisms responsible for clinical drug are unknown. In these studies antitumor agent adriamycin was found involve two mechanisms, one that decreased accumulation by P170 mechanism and another altered glutathione redox cycle, an important pathway in detoxification of reactive oxygen. This dual demonstrated cell lines had acquired multidrug-resistant phenotype human colorectal...
Purpose: To define the value of thymidylate synthase (TS), Ki-67, and p53 as prognostic markers in patients with stage II III colon carcinoma. Patients Methods: We retrospectively analyzed TS, 706 Dukes’ B (291 patients) or C (415 carcinoma who were treated either surgery alone (275 plus fluorouracil (FU)-leucovorin chemotherapy (431 National Surgical Adjuvant Breast Bowel Project (NSABP) protocols C01-C04. All three assayed using immunohistochemical techniques. Results: Using 5 years...
Cardiac surgery is a complex, high-risk procedure with potential vulnerabilities for patient safety. The evidence base describing safety hazards in the cardiovascular operating room underdeveloped but essential to guide future improvement efforts.To identify and categorise (anything that has cause preventable adverse event) room.An interdisciplinary team of researchers used prospective methods, including direct observations, contextual inquiry photographs collect hazard data pertaining...
Abstract High entropy alloys (HEAs) are an important material class in the development of next-generation structural materials, but astronomically large composition space cannot be efficiently explored by experiments or first-principles calculations. Machine learning (ML) methods might address this challenge, ML HEAs has been hindered scarcity HEA property data. In work, EMTO-CPA method was used to generate a dataset (spanning 14 elements) containing 7086 cubic structures with properties,...
Abstract Electrochemical intercalation can enable lithium extraction from dilute water sources. However, during extraction, co-intercalation of and sodium ions occurs, the response host materials to this process is not fully understood. This aspect limits rational designs for improving extraction. Here, address knowledge gap, we report one-dimensional (1D) olivine iron phosphate (FePO 4 ) as a model investigate behavior demonstrate control selectivity through kinetic manipulations. Via...
Abstract Laser powder-bed fusion (L-PBF) additive manufacturing presents ample opportunities to produce net-shape parts. The complex laser-powder interactions result in high cooling rates that often lead unique microstructures and excellent mechanical properties. Refractory high-entropy alloys show great potential for high-temperature applications but are notoriously difficult process by processes due their sensitivity cracking defects, such as un-melted powders keyholes. Here, we present a...
// Nilofer S. Azad 1 , Anthony el-Khoueiry 2 Jun Yin 3 Ann L. Oberg Patrick Flynn 4 Douglas Adkins 5 Anup Sharma Daniel J. Weisenberger Thomas Brown Prakriti Medvari Peter A. Jones 6 Hariharan Easwaran Ihab Kamel Nathan Bahary 7 George Kim 8 Joel Picus 9 Henry C. Pitot Charles Erlichman Ross Donehower Hui Shen W. Laird Richard Piekarz Stephen Baylin and Nita Ahuja Johns Hopkins University, Baltimore, MD, USA University of Southern California, Los Angeles, CA, Mayo Clinic, Rochestor, MN,...
The Oncotype DX colon cancer assay is a clinically validated predictor of recurrence risk in stage II patients. This prospective study evaluated the impact score (RS) results on physician recommendations regarding adjuvant chemotherapy T3, mismatch repair-proficient (MMR-P) Patients and Methods. Stage IIA patients were enrolled 17 centers. Patient tumor specimens assessed by RS test (quantitative reverse transcription-polymerase chain reaction) repair (immunohistochemistry). For each...
The aim of this study was to determine whether checkpoint kinase 1 inihibitor (CHK1), LY2603618, and gemcitabine prolong overall survival (OS) compared alone in patients with unresectable pancreatic cancer.Patients Stage II-IV locally advanced or metastatic cancer were randomized (2:1) either 230 mg LY2603618/1000 mg/m2 combined 1000 alone. OS assessed using both a Bayesian augment control model traditional frequentist analysis for inference. Progression-free (PFS), response rate (ORR),...
Elastic properties are essential to the mechanical performance of materials, and therefore, can be tuned design high-performance materials. In this study, elastic constants equiatomic ternary refractory multi-principal-element alloys, NbTiV, MoNbV, were investigated, using in-situ neutron diffraction first-principles calculations. The experimentally measured theoretically predicted show a good agreement. alloying effect adding Ti Mo into NbV base alloy on is studied. Particularly, elements...
Abstract Objective : An American Psychosocial Oncology Society workgroup has developed indicators of the quality psychosocial care that can be measured through review medical records. The present report describes first large‐scale use these to evaluate in outpatient oncology settings. Methods Medical records 1660 colorectal, breast and non‐small cell cancer patients seen by a oncologist 2006 at 11 practice sites Florida were reviewed for performance on care. Results Assessment emotional...
Abstract The standard enthalpy of formation a compound is the energy associated with reaction to form from its component elements. fundamental thermodynamic property that determines phase stability, which can be coupled other data calculate diagrams. Calorimetry provides only direct method by experimentally measured. However, measurement often time and intensive process. We present dataset enthalpies measured high-temperature calorimetry. phases in this include intermetallic compounds...
Reconstruction of microtia may require a temporoparietal fascia flap. The authors modified existing endoscopic harvest techniques and applied them to auricular reconstruction reduce incision size, scarring, visible alopecia. Flap design was altered include posterior occipital circulation improve perfusion decrease venous congestion. Cases open endoscope-assisted have not been compared in the literature.Seventeen patients underwent Medpor with flaps (eight nine endoscope-assisted). Physical...
A project team was formulated to create evidence-based oncology nurse generalist competencies (ONGCs) establish best practices in competency development, including high-risk tasks, critical thinking criteria, and measurement of key areas for nurses. .This article aims describe the process development ONGCs. explains how ONGCs were accomplished, includes outcomes suggestions use clinical practice. .Institutions can assess develop programs, offer educational strategies measure proficiency,...