A5115598470- Cystic Fibrosis Research Advances
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Antibiotic Resistance in Bacteria
- Asthma and respiratory diseases
- Cleft Lip and Palate Research
- COVID-19 and Mental Health
- Inhalation and Respiratory Drug Delivery
- Pediatric Urology and Nephrology Studies
- Homelessness and Social Issues
- Children's Physical and Motor Development
- Obesity, Physical Activity, Diet
- Respiratory and Cough-Related Research
- Physical Activity and Health
- Radiation Dose and Imaging
- Child Nutrition and Feeding Issues
- Congenital Ear and Nasal Anomalies
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- COVID-19 and healthcare impacts
- Immune Response and Inflammation
University of Washington
2016-2021
Seattle Children's Hospital
2016-2021
National Jewish Health
2010-2019
University of Colorado Denver
2010-2019
Pediatrics and Genetics
2019
On March 30, 2020, Public Health - Seattle and King County (PHSKC) was notified of a confirmed case coronavirus disease 2019 (COVID-19) in resident homeless shelter day center (shelter A). Residents from two other shelters (B C) used A's services. Testing for SARS-CoV-2, the virus that causes COVID-19, offered to available residents staff members at three during 30-April 1, 2020. Among 181 persons tested, 19 (10.5%) had positive test results (15 four members). April PHSKC CDC collaborated...
MDA5 is a cytosolic sensor of double-stranded RNA (ds)RNA including viral byproducts and intermediates. We studied child with life-threatening, recurrent respiratory tract infections, caused by viruses human rhinovirus (HRV), influenza virus, syncytial virus (RSV). identified in her homozygous missense mutation IFIH1 that encodes MDA5. Mutant was expressed but did not recognize the synthetic agonist/(ds)RNA mimic polyinosinic-polycytidylic acid. When overexpressed, mutant failed to drive...
Rationale: Chronic azithromycin is commonly used in cystic fibrosis based on short controlled clinical trials showing reductions pulmonary exacerbations and improved FEV1. Long-term effects are unknown.Objectives: Examine outcomes among chronic users compared with matched controls over years of use consider combined cohorts using inhaled tobramycin or aztreonam.Methods: This retrospective cohort study the U.S. Foundation Patient Registry. Incident were by FEV1% predicted rate decline rates...
Abstract: Cystic fibrosis (CF) is the most common life-shortening genetic disorder in Caucasians. With improved diagnosis and treatment, survival has steadily increased. Unfortunately, overwhelming majority of patients still die from respiratory failure caused by structural damage resulting airway obstruction, recurrent infection, inflammation. Here, we discuss role inflammation development anti-inflammatory therapies to treat CF lung disease. The inflammatory host response least addressed...
Rationale: The potential of azithromycin to alter the antimicrobial and clinical benefits inhaled tobramycin in patients with cystic fibrosis (CF) has been previously reported. interaction between intravenous antibiotics treatment pulmonary exacerbations is unknown. Objectives: To determine if chronic use as a concomitant therapy associated change lung function after receiving antibiotic regimens including or colistimethate. Methods: This was retrospective cohort study evaluating association...
To estimate functional bladder capacity (FBC) during direct radionuclide cystography and to assess the relationship between vesicoureteral reflux FBC.By using 5,165 cystograms in patients aged newborn 14 years, linear nonlinear models were fit FBC from age. Analysis was performed on girls boys separately. In a subgroup, height weight evaluated as predictors of FBC. Linear used differences predicted according sex status.The age is best described by power function. Percentiles derived this...
This article is a program description addressing implementation process and feasibility initial data on efficacy. It describes the of school-wide system-level health promotion initiative, Make School Moving Experience (MSAME), which was designed to promote physical activity in 74 Delaware elementary schools from 2009 2012. By working with create environments supportive (PA), project goal provide students opportunity participate recommended levels PA for at least 150 min per week during...