A5036601554- Prenatal Substance Exposure Effects
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Stress Responses and Cortisol
- Tracheal and airway disorders
- Digital Imaging for Blood Diseases
- Vector-borne infectious diseases
- Infant Health and Development
- Medicinal Plants and Bioactive Compounds
- Adenosine and Purinergic Signaling
- Photoreceptor and optogenetics research
- Congenital heart defects research
- Pharmacological Effects of Natural Compounds
- Viral Infections and Vectors
- Neuroscience and Neuropharmacology Research
- Congenital Heart Disease Studies
- Ion channel regulation and function
- Electroconvulsive Therapy Studies
- Immunotoxicology and immune responses
- Reproductive System and Pregnancy
- Neuroscience and Neural Engineering
- Plant-based Medicinal Research
Washington University in St. Louis
2018-2022
University of California, Los Angeles
2015-2019
Triangle
2018
Indianapolis Zoo
2018
Kentucky Science Center
2018
John Wiley & Sons (United States)
2018
University of California, San Diego
2008
Neurotransmitter signaling in the mature nervous system is well understood, but functions of transmitters immature are less clear. Although released during embryogenesis regulate neuronal proliferation and migration, little known about their role regulating early differentiation. Here, we show that GABA glutamate drive calcium-dependent embryonic electrical activity regulates transmitter specification. The number neurons expressing different changes when or blocked chronically, either using...
Autism spectrum disorder (ASD) is a complex neurodevelopmental characterized by impaired social interactions, difficulty with communication, and repetitive behavior patterns. In humans affected ASD, there male pre-disposition towards the condition to female ratio of 4:1. part due etiology ASD including genetic environmental interplay, are currently no available medical therapies improve deficits ASD. Studies in rodent models have shown promising therapeutic effects oxytocin modulating...
Nationwide, opioid misuse among pregnant women has risen four-fold from 1999 to 2014, with commensurate increase in neonates hospitalized for neonatal abstinence syndrome (NAS). NAS occurs when a fetus exposed opioids utero goes into rapid withdrawal after birth. treatment via continued post-natal exposure been suggested worsen neurodevelopmental outcomes. We developed novel model characterize the impact of and prolonged oxycodone (Oxy) on early behavior development. Via subcutaneous pump...
Neuroblastoma is the most common extracranial solid tumor diagnosed during childhood and gives rise to various heterogeneous tumors along sympathoadrenal axis. Congenital neuroblastoma accounts for 5% of total cases annually, with majority in first month after birth. Interestingly, neonates demonstrate a unique disease trajectory compared children older than 1 year age. This article will provide information on pathogenesis variable clinical presentation congenital neuroblastoma, biological...
Alkaloids, which possess a stimulating effect on the functions of progenitors various classes, were identified. The aim this study was to identify mechanisms underlying development neuroregenerative effects modified (halogenated (Cl-ion)) alkaloid songorine (mSON). To reveal participation neuronal-committed (clonogenic PSA-NCAM + cells) subventricular area cerebral hemispheres (SVZ) in realization pharmacological action substance and their under influence mSON. mSON received by halogenation...
Present work deals with specific immunologic changes that are typical to various types of mixed infection caused by viruses from Herpesviridae family during their activation phase. These include increased amounts CD3+/CD25+ lymphocytes and CD3+/CD4+ cells, decreased levels CD3+/CD95+ contents natural killer altered interrelations between the immune system parameters. Involvement cytomegalovirus or Epstein-Barr virus (EBV) in is associated some special lymphocyte subsets. I.e., a co-infection...
The aim of the study is to assess spontaneous and phytohemagglutinin (PHA)-induced proliferative cytokine secretory activity in mononuclear blood cell cultures patients with acute Lyme borreliosis (LB) over times before after antibiotic therapy as well depending on clinical severity. Materials methods. Activity blast transformation reaction (BTR) lymphocytes secretion levels interleukins (IL)-1β, IL-2, IL-6, IL-4, IL-10, IL-8, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein...
Introduction.Multiple studies on immune response in patients with various clinical forms of tick-borne encephalitis (TBE) have shown conflicting results. The study aim was to estimate the changes peripheral blood lymphocyte subset counts and activity spontaneous lipopolysaccharide (LPS)-stimulated cytokine production mononuclear leukocyte cultures febrile meningeal acute TBE.Materials methods.Groups 1 2 included 16 12 TBE, respectively. control group 13 healthy donors. Hemogram T-lymphocyte,...
ABSTRACT Nation-wide, opioid misuse among pregnant women has risen 4-fold from 1999 to 2014, with commensurate increase in neonates hospitalized for Neonatal Abstinence Syndrome (NAS). NAS occurs when a fetus exposed opioids utero goes into rapid withdrawal after birth. treatment via continued postnatal exposure been suggested worsen neurodevelopmental outcomes. We developed novel model characterize the impact of and oxycodone (Oxy) on early behavior development. Via subcutaneous pump...
ABSTRACT In utero opioid exposure is associated with lower weight and a Neonatal Opioid Withdrawal Syndrome (NOWS) at birth, along longer-term adverse neurodevelopmental outcomes mood disorders. While NOWS sometimes treated continued opioids, clinical studies have not addressed if long-term neurobehavioral are worsened postnatal to opioids. addition, pre-clinical comparing in only post-natal administration for withdrawal mitigation lacking. Therefore, we implemented rodent perinatal model of...