A5017398663- Child and Adolescent Psychosocial and Emotional Development
- Resilience and Mental Health
- Suicide and Self-Harm Studies
- Attention Deficit Hyperactivity Disorder
- Maternal Mental Health During Pregnancy and Postpartum
- Mental Health Research Topics
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Psychosomatic Disorders and Their Treatments
- Child Abuse and Trauma
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Innovations in Medical Education
- Adolescent and Pediatric Healthcare
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Traumatic Brain Injury Research
- Child Nutrition and Feeding Issues
- Early Childhood Education and Development
- Eating Disorders and Behaviors
- Stress Responses and Cortisol
- Perfectionism, Procrastination, Anxiety Studies
- Behavioral Health and Interventions
- Medical Education and Admissions
University of Cambridge
2015-2024
Cambridgeshire and Peterborough NHS Foundation Trust
2011-2024
Cambridge School
2023
Anna Freud Centre
2021
University College London
2021
National Health Service
2012-2019
American Academy of Child and Adolescent Psychiatry
2018
London School of Hygiene & Tropical Medicine
2005-2018
ACT Government
2013-2018
University of Manchester
2010-2017
Objective: The authors assessed whether clinical and psychosocial factors in depressed adolescents at baseline predict suicide attempts nonsuicidal self-injury over 28 weeks of follow-up. Method: Participants were 164 with major depressive disorder taking part the Adolescent Depression Antidepressants Psychotherapy Trial (ADAPT). Clinical symptoms, family function, quality current personal friendships, suicidal self-harm baseline. Suicidal thoughts behaviors during Results: High suicidality,...
BackgroundSuicidal thoughts and non-suicidal self-harm are common in adolescents strongly associated with suicide attempts. We aimed to identify predictors of future attempts these high-risk groups.MethodsParticipants were from the Avon Longitudinal Study Parents Children, a population-based birth cohort study UK. The sample included 456 who reported suicidal 569 at 16 years age. Logistic regression analyses used explore associations between wide range prospectively recorded risk factors...
<b>Objective</b> To determine whether a combination of selective serotonin reuptake inhibitor (SSRIs) and cognitive behaviour therapy (CBT) together with clinical care is more effective in the short term than an SSRI alone adolescents moderate to severe major depression. <b>Design</b> Pragmatic randomised controlled superiority trial. <b>Setting</b> 6 outpatient clinics Manchester Cambridge. <b>Participants</b> 208 adolescents, aged 11-17, or probable depression who had not responded brief...
Psychological treatments for adolescents with unipolar major depressive disorder are associated diagnostic remission within 28 weeks in 65-70% of patients. We aimed to assess the medium-term effects and costs psychological therapies on maintenance reduced depression symptoms 12 months after treatment.
NSSI (non-suicidal self-injury) is an important public health issue, with high prevalence and associations future mental illness suicide. To date, no large single study has tested age gender effects on their interplay psychological distress.NSSI distress were ascertained by questionnaire in a community of 2368 young people aged 14-25; proportions at each approximately equal.There was significant quadratic interaction between last month (p = 0.025): more common females ages 16-19, but there...
Only one-third of young people who experience suicidal ideation attempt suicide. It is important to identify factors which differentiate those suicide from but do not act on these thoughts.
randomised controlled trial of cognitive behaviour therapy
Up to 70% of adolescents with moderate severe unipolar major depression respond psychological treatment plus Fluoxetine (20-50 mg) symptom reduction and improved social function reported by 24 weeks after beginning treatment. Around 20% non responders appear resistant 30% relapse within 2 years. The specific efficacy different therapies the moderators mediators that influence risk for are unclear. cost-effectiveness safety treatments remain poorly evaluated.Improving Mood Psychoanalytic...
Background Non-suicidal self-injury (NSSI) is highly prevalent in adolescents and may be a behavioural marker for emergent mental illnesses. Aims To determine whether sporadic or recurrent NSSI up to the age of 14 years predicted increased risk new onset psychiatric disorder subsequent 3 years, independent symptoms social factors. Method In total, 945 individuals aged with no past/present history illness completed clinical interview questionnaire about at ages 17 years. Results Recurrent...
A ruminative style of responding to low mood is associated with subsequent high depressive symptoms and disorder in children, adolescents adults. Scores on self-report rumination scales correlate strongly scores anxiety depression symptom scales. This may confound any associations between depression. Our sample comprised 658 healthy at elevated risk for psychopathology. study applied ordinal item (non-linear) factor analysis pooled items from three questionnaires explore whether there were...
Significance Clinical depression is a severe and common illness, characterized primarily by persistent low mood lack of pleasure in usually enjoyable activities, that results significant impairment everyday living. It also involves alterations cognitive hormonal functions. There substantial variation between depressed individuals terms the causes therapeutic response, making it difficult to identify those most likely benefit from intervention treatment. We derived subtypes adolescents...
Adverse family experiences in early life are associated with subsequent psychopathology. This study adds to the growing body of work exploring nature and associations between adverse over childhood years. Primary carers 1143 randomly recruited 14-year olds Cambridgeshire Suffolk, UK were interviewed using Cambridge Early Experiences Interview (CAMEEI) assess family-focused adversities. Adversities recorded retrospectively three time periods (early later adolescence). Latent Class Analysis...
Background Although there are effective psychological treatments for unipolar major depression in adolescents, whether or not one more of the available therapies maintain reduced depressive symptoms 1 year after end treatment is known. This a non-trivial issue because maintaining lowered below clinical threshold level reduces risk diagnostic relapse into adult years. Objective To determine either two specialist treatments, cognitive–behavioural therapy (CBT) short-term psychoanalytic...
Resilience factors (RFs) help prevent mental health problems after childhood adversity (CA). RFs are known to be related, but it is currently unknown how their interrelations facilitate health. Here, we used network analysis examine the between ten in 14-year-old adolescents exposed ('CA'; n = 638) and not CA ('no-CA'; 501). We found that degree which assumed enhance each other higher no-CA compared group. Upon correction for general distress levels, global RF connectivity also differed two...
Objective: Therapy dropout is a common occurrence, especially in adolescence. This study investigated whether could be predicted from range of child, family, and treatment factors sample adolescents receiving therapy for depression. Method: draws on data 406 participants the IMPACT study, randomized controlled trial, investigating three types adolescent Logistic regression was used to estimate effects predictors odds dropout. Results: Few pre-treatment were found, with only significant being...
Background Major depression is an important and costly problem among adolescents, yet evidence to support the provision of cost-effective treatments lacking. Aims To assess short-term cost-effectiveness combined selective serotonin reuptake inhibitors (SSRIs) cognitive–behavioural therapy (CBT) together with clinical care compared SSRIs alone in adolescents major depression. Method Pragmatic randomised controlled trial UK. Outcomes costs were assessed at baseline, 12 28 weeks. Results The...
Non-suicidal self-injury (NSSI) appears to be more common among women than men, though the underlying reasons for this remain unclear. In a community sample of young adults (N = 996, aged 18-33) assessed during COVID-19 pandemic, we investigated alternative explanation NSSI prevalence gap: are likely experience feelings which lead as coping strategy, or does gap result from differences in how men and respond distress?Cross-sectional mediation moderation analyses tested self-reported...
Background: Depressed adults may show impairment in switching attention from one task to another. Rumination on negative thoughts is associated with the onset and persistence of depressive episodes. It unclear if such mood‐related ruminations are specifically slowed ability Method: Adolescents current unipolar depression ( n = 40) were compared age sex‐matched controls 38) tests general cognitive abilities completed ruminative response style questionnaire. Results: Compared controls,...