A5077171624- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Adrenal Hormones and Disorders
- Diabetes and associated disorders
- Sexual Differentiation and Disorders
- Hormonal Regulation and Hypertension
- Neuroscience of respiration and sleep
- Thyroid Cancer Diagnosis and Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Birth, Development, and Health
- Childhood Cancer Survivors' Quality of Life
- Genetics and Neurodevelopmental Disorders
- Pituitary Gland Disorders and Treatments
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Neonatal Respiratory Health Research
- Biotechnology and Related Fields
- Obesity, Physical Activity, Diet
- Congenital heart defects research
- Genetically Modified Organisms Research
- Neuroblastoma Research and Treatments
- Hypothalamic control of reproductive hormones
- Hormonal and reproductive studies
- Agricultural and Food Sciences
- Genetic Syndromes and Imprinting
University of Naples Federico II
2011-2025
Federico II University Hospital
2015-2024
University of Cambridge
2016
University of Messina
2015
I.R.C.C.S. Oasi Maria SS
2014
Subclinical hypothyroidism (SH), defined as increased TSH serum levels and normal free T4 concentrations, has been associated with an risk of coronary heart disease in adults. Data children adolescents are scanty.The objective the study was to investigate clinical biochemical cardiovascular factors mild SH (serum concentrations 4.5-10 mU/L).This is a cross-sectional controlled conducted at tertiary referral center on patients persistent idiopathic long-standing (3.2 ± 0.4 y) SH. At entry...
This retrospective study aimed to evaluate children observed for suspected precocious puberty in five Italian centers of Pediatric Endocrinology during the first wave coronavirus disease 2019 pandemic (March-September 2020), compared subjects same period previous year.The population (490 children) was divided according year observation and final diagnosis: transient thelarche, non-progressive puberty, central (CPP), or early puberty.Between March September 2020, 338 were referred 152...
To evaluate the effect of different initial levothyroxine (LT4) replacement doses on growth and intellectual outcome in patients with congenital hypothyroidism (CH) detected by neonatal screening program, longitudinal intelligence quotient (IQ) were assessed compared at 4 years age 83 CH. The divided into three groups according to LT4 dose used: (1) group 1 (n = 42) received previously recommended 6.0-8.0 microg/kg per day; (2) 2 21) a 8.1-10.0 (3) Group 3 20) 10.1-15.0 day. IQ, evaluated...
To prospectively evaluate the course of subclinical hypothyroidism (SH) in children and adolescents with no underlying diseases risk factors, which might interfere progression SH.Clinical status, thyroid function, autoimmunity were evaluated at entry after 6, 12, 24 months 92 young patients (mean age 8.1+/-3.0 years) idiopathic SH.During study, mean TSH levels showed a trend toward progressive decrease while FT(4) remained unchanged. Overall, 38 normalized their (group A): 16 between 6 12...
The treatment of children with subclinical hypothyroidism (SH) is controversial for TSH values between 4.5 and 10 mU/l. aim this cross-sectional, controlled study was to evaluate growth intellectual outcome in persistent SH who have never been treated levothyroxine.Clinical auxological parameters, thyroid function, were evaluated 36 at the age 9.7±0.6 (range 4-18.0) years. Children had followed longitudinally 3.3±0.3 2.0-9.3) years, from first diagnosis until enrollment study. Thirty-six...
<b><i>Background:</i></b> There are few studies investigating the factors which may affect different biochemical presentations of Hashimoto’s thyroiditis (HT) and these frequently based on limited pediatric populations. <b><i>Aims:</i></b> (1) To assess frequency thyroid function patterns at HT diagnosis in 608 children adolescents, (2) to analyze that status diagnosis. <b><i>Results:</i></b> At presentation, test...
Autoimmune Polyglandular Syndrome type 1 (APS-1) is a rare recessive inherited disease, caused by AutoImmune Regulator (AIRE) gene mutations and characterized three major manifestations: chronic mucocutaneous candidiasis (CMC), hypoparathyroidism (CH) Addison's disease (AD).Autoimmune conditions associated autoantibodies (Abs) were analyzed in 158 Italian patients (103 females 55 males; F/M 1.9/1) at the onset during follow-up of 23.7 ± 15.1 years. AIRE determined.The prevalence APS-1 was...
To evaluate longitudinal growth, pubertal development and final height in patients with congenital hypothyroidism (CH) detected by a neonatal screening programme, to identify factors potentially affecting growth outcome.Fifty-five (41 females) followed longitudinally from the time of diagnosis treatment (25+/-5 days) up age 17+/-0.5 years were evaluated retrospectively.Pubertal began progressed normally both males females. In boys, testicular volume 4 ml was reached at 11.3+/-1.0 years....
<i>Aim:</i> To investigate hashitoxicosis outcome in 14 children with persistent absence of thyrotropin receptor autoantibodies who were followed for 1.3-8.8 years (mean 3.5 ± 2.5). Due to a more severe presentation, 4 patients required methimazole (subgroup A1), whilst the remaining 10 cas es A2) no treatment was given. <i>Results:</i> A definitive resolution hyperthyroidism recorded 8.3 6.3 months after diagnosis, even though there wide variability between subjects...
PATIENTS with classic congenital adrenal hyperplasia (CAH) are treated lifelong glucocorticoids (GCs). Cardiovascular and metabolic effects of such therapy in adolescents have never been quantified.Our objective was to investigate left ventricular (LV) morphology, function, exercise performance CAH.We conducted a cross-sectional controlled study at tertiary referral center.Twenty patients CAH (10 females) aged 13.6 ± 2.5 years 20 healthy controls comparable for sex pubertal status were...
Objective To investigate the effect of levothyroxine (L-T4) treatment on early markers atherosclerotic disease in children with mild idiopathic subclinical hypothyroidism (SH). Design Two-year, open, case–control prospective study. Methods A total 39 children, aged 9.18±3.56 years, SH and healthy controls were enrolled Waist-to-height ratio (WHtR), blood pressure, triglycerides, cholesterol (total-C), HDL-C, LDL-C, non-HDL-C, triglycerides/HDL-C, atherogenic index (AI), homocysteine (Hcy),...
To follow-up for 5 years thyroid status evolution in 127 girls with mild (TSH 5-10 mU/l) subclinical hypothyroidism (SH) of different etiologies.The population was divided into two age-matched groups 42 and 85 either idiopathic (group A) or Hashimoto's thyroiditis (HT)-related SH B). Group B turn three subgroups, according to whether isolated associated Turner syndrome (TS) Down (DS).At the end rate who became euthyroid higher group A (61.9% vs 10.6%), whereas rates patients remained (55.3%...
Abstract Context There are only a few nationwide studies on boys with central precocious puberty (CPP) and the last Italian study is case series of 45 that dates back to 2000. Objective We aimed evaluate causes CPP in diagnosed during 2 decades Italy relative frequency forms associated nervous system (CNS) abnormalities magnetic resonance imaging (MRI) compared idiopathic ones. Methods performed national multicenter retrospective collecting data from 193 otherwise normal healthy diagnosis...
Growth hormone (GH) deficiency (GHD) in adults is associated with increased cardiovascular (CV) risk. Although some authors have documented the presence of early CV risk factors untreated GHD children, results are still inconsistent. Aim this study was to evaluate effects and GH therapy on cardiometabolic a large cohort children.Waist-to-height ratio (WHtR), triglycerides, total-, low-density lipoprotein (LDL), high-density (HDL) cholesterol, atherogenic index (AI = total /HDL cholesterol),...
Abstract Context Primary adrenal insufficiency (PAI) is a rare and potentially life-threatening condition that poorly characterized in children. Objective To describe causes, presentation, auxological outcome, frequency of crisis mortality large cohort children with PAI. Patients Methods Data from 803 patients 8 centers Pediatric Endocrinology were retrospectively collected. Results The following etiologies reported: 85% (n = 682) congenital hyperplasia (CAH) due to 21-hydroxylase deficiency...
GH deficiency (GHD) in adults is associated with a cluster of cardiovascular risk factors that may contribute to an increased mortality for disease.The aim this study was evaluate the effect GHD and replacement therapy on cardiac performance, lipid profile, insulin resistance children.This 2-yr case-control prospective study.Thirty children aged 9.3 +/- 0.5 yr 30 healthy matched controls were studied.Children studied before after 1 2 (GHD children) or no treatment (controls).Lipid serum...
Low serum IGF-1 levels have been linked to increased risk for development of type 2 diabetes. However, the physiological role in glucose metabolism is not well characterized.
OBJECTIVE: To evaluate whether long-term l-thyroxine therapy in young adults with congenital hypothyroidism may affect bone mineral density (BMD). DESIGN: Thirty-seven subjects hypothyroidism, detected by neonatal screening and longitudinally followed from the time of diagnosis treatment (26+/-4 days) up to age 17.8+/-1.0 years, were studied. METHODS: Spinal (L2-L4) BMD, measured dual-energy X-ray densitometry, quality, as amplitude-dependent speed sound (Ad-SoS) quantitative ultrasound,...