A5022692344- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- RNA and protein synthesis mechanisms
- Cardiomyopathy and Myosin Studies
- Cell Adhesion Molecules Research
- Ion channel regulation and function
- Cellular Mechanics and Interactions
Instituto Politécnico Nacional
2022-2023
Center for Research and Advanced Studies of the National Polytechnic Institute
2022-2023
Adhesion G protein-coupled receptors (aGPCRs) possess a unique topology, including the presence of GPCR proteolysis site (GPS), which, upon autoproteolysis, generates two functionally distinct fragments that remain non-covalently associated at plasma membrane. A proposed activation mechanism for aGPCRs involves exposure tethered agonist, which depends on cleavage GPS. However, this hypothesis has been challenged by observation non-cleavable exhibit constitutive activity, thus making function...
Cancer progression relies on cellular transition states accompanied by changes in the functionality of adhesion molecules. The gene for G protein-coupled receptor latrophilin-3 (aGPCR Lphn3 or ADGRL3) is targeted tumor-specific somatic mutations predominantly affecting conserved GAIN domain where most aGPCRs are cleaved. However, it unclear how these domain-altering impact function. Here, we studied cancer-related as a proxy revealing unknown functions. We found that while intra-GAIN...
Adhesion G protein-coupled receptors (aGPCRs) possess a unique topology including the presence of GPCR proteolysis site (GPS) which upon autoproteolysis generates two functionally distinct fragments that remain non-covalently associated at plasma membrane. A proposed activation mechanism for aGPCRs involves release tethered agonist depends on cleavage GPS. However, this hypothesis has been challenged by observation non-cleavable exhibit constitutive activity, thus making function GPS widely...