A5045825700- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Plant Virus Research Studies
- Vector-borne infectious diseases
- Bird parasitology and diseases
- Coccidia and coccidiosis research
- Viral-associated cancers and disorders
- Animal Behavior and Welfare Studies
- Insect and Arachnid Ecology and Behavior
- Hemiptera Insect Studies
- Physiological and biochemical adaptations
- Animal Virus Infections Studies
- Poxvirus research and outbreaks
- Viral Infectious Diseases and Gene Expression in Insects
- Mosquito-borne diseases and control
- Genital Health and Disease
- Wildlife Ecology and Conservation
- Bat Biology and Ecology Studies
- Identification and Quantification in Food
- Plant and Fungal Interactions Research
- Herpesvirus Infections and Treatments
- Global trade, sustainability, and social impact
- Genetic diversity and population structure
Center for Grain and Animal Health Research
2025
Agricultural Research Service
2018-2024
Plum Island Animal Disease Center
2017-2024
United States Department of Agriculture
2019-2024
Oak Ridge Institute for Science and Education
2017-2022
Oak Ridge Associated Universities
2017-2021
Advanced Neural Dynamics (United States)
2019
Texas A&M University
2015-2017
In 2018, senecavirus A was detected for the first time in Vietnam. This report contains complete genome of a isolate collected from pigs Kon Tum Province,
Foot-and-mouth disease (FMD), caused by FMD virus (FMDV; Aphthovirus, Picornaviridae), is a highly contagious and economically important of cloven-hoofed domestic livestock wildlife species worldwide. Subsequent to the clinical phase FMD, large proportion FMDV-infected ruminants become persistently infected carriers, defined detection FMDV in oropharyngeal fluid (OPF) samples 28 days or more post-infection. The goal this prospective study was characterize carrier state cattle subsequent...
ABSTRACT Two near full-length sequences of vesicular stomatitis Indiana virus (VSIV), representing endemic VSIV lineages circulating in cattle Mexico, are reported. These will allow us to gain more insight into the genetic relationship between viruses Mexico and emergence epizootic United States.
The convalescent subclinical carrier state of foot-and-mouth disease virus (FMDV) infection has been thoroughly investigated; contrastingly, the form new infections vaccinated and naïve hosts is recognized, but poorly understood. To investigate natural dynamics FMDV infections, a prospective, 12-month, longitudinal study was conducted in Asian buffalo (Bubalus bubalis) under conditions Pakistan, where hyperendemic. Oropharyngeal fluid (OPF) samples were obtained quarterly from 300 on 30...
The pathogenesis of foot-and-mouth disease virus (FMDV) in cattle was investigated through early and late stages infection by use an optimized experimental model for controlled contact exposure. Time-limited exposure to FMDV-infected pigs led primary FMDV the nasopharyngeal mucosa both vaccinated nonvaccinated cattle. In cattle, generalized rapidly cause clinical disease, without apparent amplification lungs prior establishment viremia. Vaccinated were protected against viremia; however, all...
Foot-and-mouth disease (FMD) field studies have suggested the occurrence of simultaneous infection individual hosts by multiple virus strains; however, pathogenesis foot-and-mouth (FMDV) coinfections is largely unknown. In current study, cattle were experimentally exposed to two FMDV strains different serotypes (O and A). One cohort was simultaneously infected with both viruses, while additional cohorts initially A subsequently superinfected O after 21 or 35 days. Coinfections confirmed...
In recent years, foot-and-mouth disease virus (FMDV) serotype O, topotype Middle East-South Asia (ME-SA), lineage Ind-2001d has spread from the Indian subcontinent to East, North Africa, and Southeast Asia. current report, we describe first detection of this in Vietnam May, 2015 Đắk Nông province. Three subsequent outbreaks caused by genetically related viruses occurred between May-October, after which was not detected clinical for at least 15 months. The observed affected (in chronological...
Viral recombination contributes to the emergence of novel strains with potential for altered host range, transmissibility, virulence, and immune evasion. For foot-and-mouth disease virus (FMDV), cell culture experiments phylogenetic analyses field samples have demonstrated occurrence recombination. However, frequency associated virus-host interactions within an infected not been determined. We previously reported detection interserotypic recombinant FMDVs in oropharyngeal fluid (OPF) 42%...
The role of foot-and-mouth disease virus (FMDV) persistently infected ruminants in initiating new outbreaks remains controversial, and the perceived threat posed by such animals hinders international trade FMD-endemic countries. In this study we report longitudinal analyses genetic antigenic variations FMDV serotype O/ME-SA/Ind2001d sublineage during naturally occurring, persistent infection cattle buffalo at an organised dairy farm India. proportion from which RNA was recovered not...
The unicellular blood parasites in the order Haemosporida are highly diverse, infect many vertebrates, responsible for a large disease burden among humans and animals, have reemerged as an important model system to understand evolutionary ecological dynamics of host-parasite interactions. phylogenetics systematics limited by poor sampling different vertebrate host taxa. We surveyed wild whooping cranes (Grus americana) sandhill canadensis) (Aves: Gruiformes) using combination morphological...
Transboundary movement of animals is an important mechanism for foot-and-mouth disease virus (FMDV) spread in endemic regions, such as Cameroon. Several transboundary animal trade routes cross the Far North Region Cameroon, and cattle moved on foot along these often come contact with native (sedentary transhumant) herds. The purpose this study was to investigate role epidemiology FMDV A total 582 oropharyngeal fluid (OPF) samples were collected from asymptomatic at official border check...
We report the polyprotein coding sequence of newly defined Ind2001e sublineage foot-and-mouth disease virus (FMDV) serotype O, isolated from a bovine epithelial tissue sample collected in 2017 Kon Tum Province, Vietnam. This discovery updates FMDV diversity Vietnam, has implications for epidemiology, and influences future vaccine selections.
We conducted an integrative analysis to elucidate the spatial epidemiological patterns of Vesicular Stomatitis New Jersey virus (VSNJV) during 2014-15 epizootic cycle in United States (US). Using georeferenced VSNJV genomics data, confirmed vesicular stomatitis (VS) disease cases from surveillance, and a suite environmental factors, our study assessed phylogenetic similarity compare VS reported 2014 2015. Despite uncertainties incomplete sampling cross-scale processes, suggested multiple...
For the first time, we describe phylogenomic signatures of an epidemic lineage vesicular stomatitis Indiana virus (VSIV). We applied multiple evolutionary analyses to a dataset 87 full-length genome sequences representing circulation VSIV in US between 2019 and 2020. Based on phylogenetic analyses, predicted ancestral relationship this with specific group isolates circulating endemic zone Chiapas, Mexico. Subsequently, our findings indicate that diversified into at least four different...
While the population of endangered whooping cranes (Grus americana) has grown from 15 individuals in 1941 to an estimated 304 birds today, growth is not sufficient support a down-listing species threatened status. The degree which disease may be limiting unknown. One potential concern caused by two crane-associated Eimeria species: gruis and E. reichenowi. Unlike most Eimeria, are localized intestinal tract, these multiply systemically cause potentially fatal disease. Using non-invasive...
We report the laboratory analysis of 125 clinical samples from suspected cases foot-and-mouth disease (FMD) in cattle and Asian buffalo collected Pakistan between 2008 2012. Of these samples, 89 were found to contain viral RNA by rRT-PCR, which 88 also infectious FMD virus (FMDV) isolation (VI), with strong correlation tests (κ = 0.96). Samples that VI-positive serotyped antigen detection ELISA (Ag-ELISA) VP1 sequence acquisition analysis. Sequence data identified FMDV serotypes A (n 13), O...
Continuous surveillance for foot-and-mouth disease (FMD) in endemic settings such as West Africa is imperative to support improved local and regional control plans, with the long-term goal of eradication. This paper describes genetic characterization FMD viruses (FMDV) obtained from outbreaks Nigeria (n = 45) Cameroon 15) during 2016 archival samples 3) retrieved a 2014 outbreak Nigeria. These were analysed context previously published FMDV sequences region. Four serotypes: O, A, SAT1 SAT2,...
Foot-and-mouth disease (FMD) is one of the most economically important livestock diseases worldwide. Following clinical phase FMD, a large proportion ruminants remain persistently infected for extended periods. Although extinction this carrier state occurs continuously at animal and population levels, studies vary widely in their estimates duration persistent infection. There need robust statistical models to capture dynamics infection sake guiding FMD control trade policies. The goal...
In 2006, vesicular stomatitis New Jersey virus (VSNJV) caused outbreaks in Wyoming (WY) horses and cattle after overwintering 2004 2005. Within two weeks of the outbreak onset, 12,203 biting flies 194 grasshoppers were collected near three equine-positive premises Natrona County, WY. Insects identified to species level tested by RT-qPCR for VSNJV polymerase (L) phosphoprotein (P) gene RNA. Collected dipterans known be competent VSV transmission included Simulium black Culicoides midges. L P...
DATA REPORT article Front. Vet. Sci., 14 February 2023Sec. Veterinary Epidemiology and Economics Volume 10 - 2023 | https://doi.org/10.3389/fvets.2023.1110483
For the first time, we describe phylogenomic signatures of an epidemic lineage vesicular stomatitis Indiana virus (VSIV). We applied multiple evolutionary analyses to a dataset full-length genome sequences representing circulation VSIV in US between 2019 and 2020. Based on phylogenetic analyses, predicted ancestral relationship this with specific group isolates circulating endemic zone Chiapas, Mexico. Subsequently, our findings indicate that diversified into at least four different...
Transboundary movement of animal feed and ingredients has been identified as a route for pathogen incursions. While imports animals animal-derived products are highly regulated the purpose infectious disease prevention, there less consideration viability agents in inanimate products, such feed. This study investigated ability foot-and-mouth virus (FMDV) to remain contaminant commercial whole pig select ingredients, establish minimum dose (MIDF ) required cause (FMD) pigs that consumed...
Development of a foot-and-mouth disease (FMD) carrier state following FMD virus (FMDV) infection is well-established phenomenon in cattle. However, the proportion cattle likely to become carriers and duration at herd or population-level are incompletely understood. The objective this study was examine epidemiologic economic impacts vaccination-to-live strategy disease-free region country. We developed simulated scenarios spread control US livestock population, which included depopulation for...