A5061417458- Dental materials and restorations
- Herpesvirus Infections and Treatments
- Connexins and lens biology
- Surgical site infection prevention
- Cytomegalovirus and herpesvirus research
- Dental Implant Techniques and Outcomes
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Cardiac, Anesthesia and Surgical Outcomes
- Urinary Tract Infections Management
- Corneal surgery and disorders
- Dental Radiography and Imaging
- Dental Erosion and Treatment
- Advanced Glycation End Products research
- Virus-based gene therapy research
- Surface Modification and Superhydrophobicity
- Hernia repair and management
- Lipid Membrane Structure and Behavior
- Reservoir Engineering and Simulation Methods
- Dental Research and COVID-19
- Nitric Oxide and Endothelin Effects
- Electron Spin Resonance Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Bone Tissue Engineering Materials
VA Boston Healthcare System
2013-2025
United States Department of Veterans Affairs
2025
Veterans Health Administration
2025
Boston VA Research Institute
2020-2024
Boston University
2018-2023
Cleveland Clinic
2023
Medical College of Wisconsin
2012-2022
Cincinnati Children's Hospital Medical Center
2020
University of Cincinnati Medical Center
1993-2020
Pfizer (United States)
2019
<h3>Importance</h3> The benefits of antimicrobial prophylaxis are limited to the first 24 hours postoperatively. Little is known about harms associated with continuing after skin closure. <h3>Objective</h3> To characterize association type and duration surgical site infection (SSI), acute kidney injury (AKI), and<i>Clostridium difficile</i>infection. <h3>Design, Setting, Participants</h3> In this multicenter, national retrospective cohort study, all patients within Veterans Affairs health...
Eravacycline (TP-434 or 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline) is a novel fluorocycline that was evaluated for antimicrobial activity against panels of recently isolated aerobic and anaerobic Gram-negative Gram-positive bacteria. showed potent broad-spectrum 90% the isolates (MIC90) in each panel at concentrations ranging from ≤0.008 to 2 μg/ml all species except those Pseudomonas aeruginosa Burkholderia cenocepacia (MIC90 values 32 both organisms). The antibacterial...
The translucency of comparable shades five dental porcelains was determined. Both direct transmittance and total were measured at wavelengths 400 - 700 nm. For 1 mm porcelain, the values for low averaged 0.13 percent, whereas 26.8 percent. Transmittance increased with increasing incident wavelength. These results indicated a high degree light scattering.
Traditionally, dental-shade-guide standards are designated in terms of Munsell hue (H), value (V), and chroma (C). However, ΔE color differences proposed as ADA tolerances for shade guides the CIE L*a*b* system. The purpose this study was to evaluate a new color-difference equation, estimation small by parameters. published values Bioform shade-guide tooth colors determined with Beckman spectrophotometer were used. Color among 276 combinations 24 calculated Eq. 1, use notation, also equation...
The selection of an appropriate material that duplicates the appearance natural tooth structure is very important in restorative dentistry. Photometric and colorimetric analysis techniques offer great potential as a tool for aiding duplication process. degree to which these will be useful depends on accuracy precision with they can applied translucent well opaque surfaces. purpose this investigation was evaluate performance three currently-available photometric devices. capabilities...
ABSTRACT TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major resistance mechanisms, including tetracycline-specific efflux and ribosomal protection. The mechanism of action was assessed using both cell-based in vitro assays. In Escherichia coli cells recombinant tetracycline genes, the MIC (0.063 μg/ml) unaffected by tet (M), (K), (B) increased to 0.25 4 μg/ml presence (A) (X), respectively. Tetracycline, contrast, significantly less...
The contrast ratio, light reflectivity, scattering coefficient, and absorption coefficient of four composites an unfilled resin were calculated algebraically from reflection spectrophotometric data using Kubelka's equations. correlation between experimental values ratio was 0.9996. Values infinite optical thickness ranged 4.19 to 6.70 mm.
This and the accompanying report (DOI: 10.1021/jm201467r ) describe design, synthesis, evaluation of a new generation tetracycline antibacterial agents, 7-fluoro-9-substituted-6-demethyl-6-deoxytetracyclines ("fluorocyclines"), accessible through recently developed total synthesis approach. These fluorocyclines possess potent activities against multidrug resistant (MDR) Gram-positive Gram-negative pathogens. One fluorocyclines, 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline...
Background The optimal regimen for perioperative antimicrobial prophylaxis is controversial. Use of combination with a beta-lactam plus vancomycin increasing; however, the relative risks and benefits associated this strategy are unknown. Thus, we sought to compare postoperative outcomes following administration 2 antimicrobials versus single agent prevention surgical site infections (SSIs). Potential harms regimens, including acute kidney injury (AKI) Clostridium difficile infection (CDI),...
Surgical site infection has been shown to decrease survival in veterans by up 42%. The association of 30-day postoperative infections with long-term the overall surgical population remains unknown.To determine whether exposure is associated increased incidence and mortality during days 31 365.In this retrospective observational cohort study, undergoing major surgery through Veterans Health Administration from January 2008 December 2015 were included. Stabilized inverse probability treatment...
Translucency of human dental enamel was determined by total transmittance wavelengths from 400 to 700 nm. The transmission coefficient at 525 nm 0.481 mm -1 . Total light through increased with increasing wavelength. Human tooth is more translucent higher wavelengths. translucency wet and after dehydration also measured transmittance. decreased 0.482 0.313 reversed on rehydration. decrease in occurred as a result the replacement water around prisms air during dehydration.
• The clearance of intravitreally injected triamcinolone acetonide was monitored by both indirect ophthalmoscopy and high-performance liquid chromatography (HPLC) found to be more rapid than previously reported others. Twenty-four rabbits were in each eye with 0.4 mg acetonide. Three sacrificed at intervals ranging from one hour 46 days. vitreous then harvested processed for HPLC analysis. Triamcinolone the internal standard prednisolone identified quantitated use HPLC, which sensitive...
The contrast gloss and the average roughness were measured for four commercial composite filling materials. Using a factorial design, each material was subjected to available finishing methods. A significant difference found in among methods, linear regression is given which relates inverse of roughness. Surface proposed as playing major role esthetic appearance restorations.
<h3>Importance</h3> Umbilical hernia repair is one of the most commonly performed general surgical procedures. However, there little consensus about factors that lead to umbilical recurrence. <h3>Objective</h3> To better understand associated with long-term <h3>Design, Setting, and Participants</h3> A retrospective cohort 332 military veteran patients who underwent was studied between January 1, 1998, December 31, 2008, at VA Boston Healthcare System. Recurrence mortality outcomes were...