A5001901409- Vitamin C and Antioxidants Research
- Burn Injury Management and Outcomes
- Motor Control and Adaptation
- Healthcare Policy and Management
- Drug-Induced Hepatotoxicity and Protection
- Balance, Gait, and Falls Prevention
- Emergency and Acute Care Studies
- Hospital Admissions and Outcomes
- Developmental Biology and Gene Regulation
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Disaster Response and Management
- Zebrafish Biomedical Research Applications
- Muscle activation and electromyography studies
- Adipose Tissue and Metabolism
Karolinska Institutet
2017-2021
Baystate Health
2017-2019
University of Massachusetts Chan Medical School
2017-2019
Baystate Medical Center
2017
Massachusetts General Hospital
2004-2007
Shriners Hospitals for Children - Boston
2006-2007
Shriners Hospitals for Children - Erie
2004-2006
Harvard University
2004-2006
Burn injury initiates an inflammatory response as part of the healing process that is associated with extensive metabolic adjustments. While most studies have focused on understanding these changes from a biochemical perspective, not much work has been done to characterize processes at gene expression level. As first step, we comprehensively analyzed in rat livers during 24 h after burn using Affymetrix GeneChips, which showed 339 genes be differentially expressed statistical significance P...
Locomotion, scratching, and stabilization of the body orientation in space are basic motor functions which critically important for animal survival. Their execution requires coordinated activity muscles located left right halves body. Commissural interneurons (CINs) critical elements neuronal networks underlying left–right coordination. V0 (characterized by early expression transcription factor Dbx1) contain a major class CINs spinal cord (excitatory, V ; inhibitory, D ), small subpopulation...
Abstract Severe injury activates many stress‐related and inflammatory pathways that can lead to a systemic hypermetabolic state. Prior studies using perfused rat livers have identified intrinsic metabolic flux changes were not dependent upon the continual presence of elevated stress hormones substrate loads. We investigated hypothesis such may be due persistent alterations in gene expression. A response was induced rats by applying moderate burn followed 2 days later cecum ligation puncture...
Introduction: Patient progress, the movement of patients through a hospital system from admission todischarge, is foundational component operational effectiveness in healthcare institutions. Optimalpatient progress key to delivering safe, high-quality and high-value clinical care. The Baystate PatientProgress Initiative (BPPI), cross-disciplinary, multifaceted quality process improvement project, waslaunched on March 1, 2014, with primary goal optimizing patient for adult patients.Methods:...
Admitted patients boarding in the emergency department (ED) while awaiting inpatient beds represent a bottleneck patient flow. We sought to examine impact on flow and potential for cost savings by an active management of boarded ED medical admissions hospitalist-led team, which included hospitalist, advanced practitioner, case manager.This was retrospectively conducted analysis quality improvement pilot intervention implemented at large tertiary center. analyzed admitted under observation...
Mice are frequently used in analyses of the locomotor system. Although forward locomotion (FWL) intact mice has been studied previously, backward (BWL) never analyzed. The aim present study was to compare kinematics FWL and BWL performed different environmental conditions (i.e., a tunnel, on treadmill, an air-ball). In all setups, average speed step amplitude during were significantly reduced compared with FWL. cycle duration varied greatly both BWL. swing twice shorter than each setup....
Severe injury activates many stress-related and inflammatory pathways leading to a systemic hypermetabolic state. Prior studies on livers isolated from animal models have identified intrinsic metabolic flux changes that were not dependent upon the continual presence of elevated stress hormones substrate loads. We investigated whether such may be due more persistent alterations in gene expression enzyme protein levels. induced response rats by applying, under general anesthesia,...