A5005425076- Polymer composites and self-healing
- Multiple Myeloma Research and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Silicone and Siloxane Chemistry
- Laser and Thermal Forming Techniques
- Advanced machining processes and optimization
- Protein Degradation and Inhibitors
- Injection Molding Process and Properties
- Advanced Surface Polishing Techniques
- Cellular and Composite Structures
- Polymer Nanocomposites and Properties
- Fiber-reinforced polymer composites
- Manufacturing Process and Optimization
- Histone Deacetylase Inhibitors Research
- Advanced Materials and Mechanics
- Laser Material Processing Techniques
- Mechanical Behavior of Composites
- Tribology and Lubrication Engineering
- Material Properties and Applications
- Polymer Foaming and Composites
- Structural Analysis and Optimization
- Advanced Machining and Optimization Techniques
- Epoxy Resin Curing Processes
- Natural Fiber Reinforced Composites
- Monoclonal and Polyclonal Antibodies Research
University of Rome Tor Vergata
2016-2025
Dana-Farber Cancer Institute
2008-2023
Harvard University
2008-2023
Mercatorum University
2021
Polymer Research Institute
2018
Massachusetts General Hospital
2010-2016
Italian Aerospace Research Centre
2016
Instituto Politécnico Nacional
2013
Brigham and Women's Hospital
2010-2011
Abraxis (United States)
2010
Abstract Purpose: We investigated the antitumor effect of murine/human chimeric CD138-specific monoclonal antibody nBT062 conjugated with highly cytotoxic maytansinoid derivatives against multiple myeloma (MM) cells in vitro and vivo. Experimental Design: examined growth inhibitory BT062-SPDB-DM4, BT062-SMCC-DM1, BT062-SPP-DM1 MM cell lines primary tumor from patients. also vivo activity these agents murine xenograft model human severe combined immunodeficient (SCID) mice bearing implant...
Abstract The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway mediates multiple myeloma (MM) cell proliferation, survival, and development drug resistance, underscoring the role mTOR inhibitors, such as rapamycin, with potential anti-MM activity. However, recent data show a positive feedback loop from mTOR/S6K1 to Akt, whereby Akt activation confers resistance inhibitors. We confirmed that suppression signaling in MM cells by was associated upregulation...
Shape memory composites (SMCs) are attractive materials as they combine typical mechanical and functional properties of with shape properties. Such can be given to composite structures by using polymer (SMP) matrices or integrating parts made SMPs. In the case integration, flexible skins applied over a foam core obtaining sandwich that shaped change its stiffness reduce volume. After application stimulus (generally heating) initial recovered. Future applications for this class...
Summary Proteasome inhibition induces the accumulation of aggregated misfolded/ubiquitinated proteins in aggresome; conversely, histone deacetylase 6 ( HDAC 6) blocks aggresome formation. Although this rationale has been basis proteasome inhibitor PI ) and combination studies, role disruption formation by not yet studied multiple myeloma MM ). The present study aimed to evaluate impact carfilzomib CFZ with a selective (ricolinostat) cells respect aggresome‐proteolysis pathway. We observed...
KDM3A is implicated in tumorigenesis; however, its biological role multiple myeloma (MM) has not been elucidated. Here we identify KDM3A-KLF2-IRF4 axis dependence MM. Knockdown of toxic to MM cells vitro and vivo. maintains expression KLF2 IRF4 through H3K9 demethylation, knockdown triggers apoptosis. Moreover, directly activates reciprocally upregulates KLF2, forming a positive autoregulatory circuit. The interaction with bone marrow milieu mediates survival cells. Importantly, silencing...
The aim of this work is the qualification commercially available collagen membranes in a comparative manner. natural origin makes standardization difficult. Nevertheless, through dimensional and mechanical measures it possible to mechanically qualify membranes, compare them.Three used Guided Bone Regeneration (GBR) Tissue (GTR) techniques, namely Bio-Gide, Collprotect Jason, were chosen for comparison. Quasi-static (tensile tests) time-dependent (stress relaxation test) tests together with...
Aurora kinases, whose expression is linked to genetic instability and cellular proliferation, are being investigated as novel therapeutic targets in multiple myeloma (MM). In this study, we the preclinical activity of a small-molecule multitargeted kinase inhibitor, AT9283, with potent against A, B, Janus 2/3.We evaluated vitro antimyeloma AT9283 alone combination lenalidomide vivo efficacy by using xenograft mouse model human MM.Our data showed that induced cell-growth inhibition apoptosis...
Abstract This work shows the application of several experimental methods to measurement interfacial tension, σ, between two immiscible polymers. A quantitative knowledge tension is important in view crucial role that this parameter plays polymer blend processing. Common all presented here are main points. The first σ obtained from experiments where shape interface liquids directly observed by means optical microscopy techniques. second point geometry controlled a balance force and viscous...
The development of biocompatible nanomaterials that interface with human skin and tissue is critical for advancing prosthetics other therapeutic medical needs. In this perspective, the nanoparticles cytotoxicity antibiofilm properties biocompatibility characteristics are important. Metallic silver (Ag) exhibits good biocompatibility, but it often challenging to integrate into a nanocomposite without compromising its optimal applications. study, new polymer nanocomposites (PNCs) ultra-low...
Damping composite laminates have been produced by compression molding of commercial thermosetting carbon fiber reinforced prepregs with different interlayers. A double-stage experimental campaign was implemented to select optimal candidates for these interlayers improve laminate damping. In the first stage, dynamic mechanical analysis (DMA) carried out on inert, thermoplastic and materials. Measured loss factors ranged between 0.06 0.34. DMA bending tests were also small size using those as...
Direct molding is a compression process of thermoset particles without the addition any linking agent or binder. It suitable for recycling end-of-life fiberglass other waste from manufacturing products. In this study, first time, feasibility powder, collected an industry, shown in case vinyl ester matrix. Powders have been directly molded, pre-treatment such as sieving, to manufacture small samples four-point bending tests. Supplied powders characterized by microscopy and thermal analysis....
Abstract. A novel architecture of shape memory polymer composite (SMPC) sandwich actuator has been designed and prototyped. Epoxy foams obtained by a solid-state process without the use foaming agent were placed in center device. High performance Carbon Fiber Reinforced (CFR) prepreg was used for external skins at edges device to increase stiffness actuator. Thermal activation through flexible heater powered with maximum tension 26 V. Moreover, SM thin layer (interlayer) same resin foam...
A solid-state process was used to produce epoxy foams with different contents of nano-clay (up 10%wt). The foam properties were studied by means numerous tests: X-ray analysis, dynamic mechanical tests (compression, flexure, indentation, stress relaxation). straightening effect the filler investigated and related loading conditions intrinsic resin matrix. Small large samples produced changing number solid precursors during foaming. In end, shape recovery showed that composite exhibit...