A5077424025- Skin Protection and Aging
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Pharmacological Effects of Natural Compounds
- melanin and skin pigmentation
- Endoplasmic Reticulum Stress and Disease
- Health and Conflict Studies
- Inflammatory Bowel Disease
- Hepatitis B Virus Studies
- Photodynamic Therapy Research Studies
- Pharmacological Effects of Medicinal Plants
- Plant responses to water stress
- Ginseng Biological Effects and Applications
- Bone Metabolism and Diseases
- Morinda citrifolia extract uses
- Lipid metabolism and biosynthesis
Academy of Scientific and Innovative Research
2015-2022
Indian Institute of Integrative Medicine
2015-2022
Council of Scientific and Industrial Research
2017-2021
Ultraviolet (UV) radiation–induced skin damage contributes strongly to the formation of melanoma, a highly lethal form cancer. Quercetin (Qu), most widely consumed dietary bioflavonoid and well known inhibitor phosphoinositide 3-kinase (PI3K) mitogen activated protein (MAP) kinase signalling, has been reported be chemopreventive in several forms non-melanoma cancers. Here, we report that treatment ultraviolet (UV)-B-irradiated B16F10 melanoma cells with quercetin resulted dose dependent...
Defective autophagy has been linked to lipotoxicity in several cellular models. We aimed investigate lipid-stimulated hepatoma (Huh7) cells and tested whether 4-phenyl butyric acid (4-PBA), a chemical chaperone, beneficial role hepatic fat accumulation lipotoxicity. report that long-term (24 h) exposure of hepatocytes palmitate block autophagic flux leads lipid cell death. Western blotting analysis showed increased SQSTM1/p62, decreased expression Beclin1 Atg7 palmitate-treated cells....
DNA is the main target for UV-B-irradiation-induced skin photodamage and accounts 90 % of all non-melanoma cancers.In this study, we explored mechanistic basis photoprotective effect Trigonelline, a naturally occurring alkaloid from Trigonella foenum-graecum, against UV-B-induced oxidative Damage Response using Primary Human Dermal Fibroblasts (HDFs) BALB/C mice as models photodamage.Primary HDFs were subjected to UV-B exposure (10 mJ/cm2) with or without TG 24 h. Effect treatment was...
Glycyrrhizic acid (GA), a natural triterpene, has received attention as an agent that protective effects against chronic diseases including ultraviolet UV-B-induced skin photodamage. However, the mechanism of its effect remains elusive. Here, we used immortalized human keratinocyte cell line (HaCaT) and small animal model (BALB/c mice), to investigate GA oxidative damage, additionally, delineated molecular mechanisms involved in UV-B-mediated inflammatory apoptotic response. In HaCaT cells,...
Excessive exposure to UV radiation negatively affects the human skin, characterized by photo-damage (premature aging & carcinogenesis). UV-B causes about 90% of non-melanoma skin cancers damaging de-oxy ribonucleic acids (DNA). We have previously reported that induces photodamage through oxidative Endoplasmic Reticulum (ER) stresses and Glycyrrhizic acid (GA), a natural triterpene, protects cells against such stresses. elicits signalling cascade activation proteins involved in sensing,...
Ultraviolet (UV) exposure to the skin causes photo-damage and acts as primary etiological agent in photo-carcinogenesis. UV-B induces cellular damage is major factor challenging homeostasis. Autophagy allows fundamental adaptation of cells metabolic oxidative stress. Cellular dysfunction has been observed aged tissues toxic insults undergoing Conversely, promising anti-aging strategies aimed at inhibiting mTOR pathway have found significantly improve aging-related disorders. Recently,...
Cutaneous photodamage is incited via exposure of ultraviolet-B (UV-B) radiation to skin, characterized by the manifestation oxidative stress, inflammation, collagen degradation and apoptosis which translates external aging signs such as wrinkle formation leathery skin appearance. Meanwhile, it increases cellular susceptibility photocarcinogenesis. Several studies have accumulated evidence regarding usage natural agents in reversing clinical photoaging well preventing photo-toxicity at...
Melanoma is an aggressive form of cancer with poor prognosis and survival rates limited therapeutic options. Here, we report the anti-melanoma effect 3-O-prenyl glycyrrhetinic acid (NPC-402), a derivative glycyrrhtinic acid, from reputed medicinal plant Glycyrrhiza glabra against B16F10 cells. We studied cytotoxic NPC-402 on melanoma cells investigated role mitogen-activated protein (MAP) kinase, AKT axis, endoplasmic reticulum (ER) stress/unfolded response (UPR)-mediated autophagy as...
Every year there’s a marked increase in the number of cancer patients registered valley’s premiere tertiary care institute, SKIMS, where increasing patients, especially from poor backgrounds, continue to pour for treatment. Sounding alarm bells, leading oncologists caution that has become one killer disease Kashmir and need more, better, awareness, latest treatment facilities ease suffering rising valley. In this brief comment, going beyond statistics, I put spotlight on various aspects reasons rise