A5042982643- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Axon Guidance and Neuronal Signaling
- Vascular Anomalies and Treatments
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Laser Applications in Dentistry and Medicine
- Nuts composition and effects
- Hippo pathway signaling and YAP/TAZ
- Salivary Gland Disorders and Functions
- Vascular Malformations Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Cancer and Skin Lesions
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- Extracellular vesicles in disease
- Single-cell and spatial transcriptomics
- Vascular Malformations and Hemangiomas
- Ferroptosis and cancer prognosis
Huazhong University of Science and Technology
2017-2024
Union Hospital
2017-2024
Anhui University of Science and Technology
2024
Wuhan University
2016-2022
Union Hospital
2018-2022
Hubei Zhongshan Hospital
2021-2022
Cancer-associated fibroblasts (CAFs) have been widely reported to promote tumor angiogenesis. However, the underlying mechanisms of proangiogenic switch CAFs remain poorly understood. This study aims clarify CAFs. NIH/3T3 cells were treated with B16 and B16F10-derived exosomes. Then markers factors detected by RT-PCR Western blot. CCK-8 assay, transwell migration tube formation in vivo Matrigel plug assay conducted determine capability blot AG490 used investigate role Janus kinase 2/signal...
This meta-analysis investigated the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and lymph node/distant metastasis. Relevant sources were identified from MEDLINE, EMBASE, PubMed, Cochrane Library. Studies that reported odds ratio (OR)/risk (RR)/hazard (HR) with 95% confidence intervals (CIs) for associations of interested outcomes included. Pooled effect estimates obtained by using random- or fixed-effect model depending on heterogeneity across these studies. Sixteen...
Abstract Accumulating evidence implies that cell fusion is one of the driving forces cancer invasion and metastasis. However, considerably less still known about triggering factors underlying mechanisms associated with cancer-host fusion, particularly in inflammatory tumor microenvironment. In this study, we confirmed factor TNF-α could enhance between squamous carcinoma cells 9 (SCC-9) human umbilical vein endothelial (HUVEC). Further study revealed promote up-regulation syncytin-1 SCC-9...
Abstract A decline in mucosal vascularity is a histological hallmark of oral submucous fibrosis (OSF), premalignant disease that largely induced by betel quid chewing. However, the lack available models has challenged studies angiogenesis OSF. Here, we found expression thrombospondin 1 (THBS1), an endogenous angiostatic protein, was elevated stroma tissues with Using fibroblast-attached organoid (FAO) model, overexpression THBS1 OSF stably recapitulated vitro. In FAO treatment arecoline,...
Chewing areca nut is closely associated with oral squamous cell carcinoma (OSCC). The current study aimed to investigate potential associations between extract (ANE) and cisplatin toxicity in OSCC cells. cells (Cal-27 Scc-9) viability apoptosis were analyzed after treatment ANE and/or cisplatin. expressions of proteins autophagy the AMP-activated protein kinase (AMPK) signaling network evaluated. We revealed that advanced patients chewing habits presented higher LC3 expression poorer...
By utilizing machine learning, we can identify genes that are associated with recurrence, invasion, and tumor stemness, thus uncovering new therapeutic targets.
N6-methyladenosine (m6A) RNA modification regulators play an important role in many human diseases, and its abnormal expression can lead to the occurrence development of diseases. However, their significance pulpitis remains largely unknown. Here, we sought identify validate m6A regulatory network pulpitis.Gene data for normal pulp tissues from public GEO databases were analyzed. Bioinformatics analysis including Gene ontology (GO) functional, Kyoto encyclopedia genes genomes (KEGG) pathway...
Abstract Venous malformations (VM) are localized defects in vascular morphogenesis manifested by dilated venous channels with reduced perivascular cell coverage. As a vital enzyme for extracellular matrix (ECM) deposition, lysyl oxidase (LOX) plays important roles development and diseases. However, the expression significance of LOX unknown VM. Herein, 22 VM specimens eight samples normal skin tissues were evaluated immunohistochemically LOX, α‐smooth muscle actin (α‐SMA) transforming growth...
Psychotherapy is effective in treating various types of mental disorders. However, the biological processes underlying its therapeutic efficacy relief depression and anxiety remain unclear. An approach to investigating these mechanisms derives from an understanding disease pathogenesis, which dysfunction brain-derived neurotrophic factor (BDNF) strongly implicated. This study provides a review studies link between talking therapies measures BDNF variability, latter determined by plasma serum...