A5005382899- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Peroxisome Proliferator-Activated Receptors
- Liver physiology and pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes and associated disorders
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Liver Diseases and Immunity
- Inflammation biomarkers and pathways
- Ginger and Zingiberaceae research
Wenzhou Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
Renji Hospital
2020-2022
Shanghai Jiao Tong University
2020-2022
Shanghai Institute of Hematology
2020
Ministry of Health of the Russian Federation
2020
Shanghai Cancer Institute
2020
Abstract Background and Aim Chronic inflammation links closely to insulin resistance lipid metabolism in nonalcoholic fatty liver disease (NAFLD). Macrophage M1 activation plays an important role the initiation continuing of pro‐inflammatory response NAFLD. Our study was investigate whether macrophage M1/M2 polarization switching would affect hepatic through modulation peroxisome proliferator‐activated receptor‐gamma (PPAR‐γ) activity vivo vitro . Methods RAW264.7 macrophages were treated...
Abstract Background & Aims Macrophages display remarkable plasticity and can interact with surrounding cells to affect hepatic immunity tissue remodelling during the progression of liver diseases. Peroxisome proliferator‐activated receptor gamma (PPARγ) plays a critical role in macrophage maturation, polarization metabolism. In this study, we investigated PPARγ macrophage–hepatic stellate cell (HSC) interaction non‐alcoholic steatohepatitis (NASH) development. Methods Wild‐type, Pparg...
Lipid metabolism disorder and inflammatory-immune activation are vital triggers in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Various studies have shown that PPAR-γ exerts potent anti-inflammatory immunomodulatory properties. However, little is known about regulation activity modulating cell crosstalk NAFLD.To investigate whether lipid-laden hepatocytes affects macrophage polarization inflammation.Primary were isolated from wild-type C57BL6/J mice or hepatocyte-specific...
Abstract Background and Aim Triggering receptor expressed on myeloid cells 2 (TREM2) plays crucial roles in metabolic homeostasis inflammatory response. Altered function macrophages could modulate their activation immune phenotype. The present study aimed to investigate the expression of TREM2 non‐alcoholic fatty liver disease (NAFLD) clarify underlying mechanism lipid metabolism oxidative stress. Methods Hepatic its relationship with NAFLD progression were analyzed patients mice fed a...
Hepatic steatosis commonly occurs in some chronic liver diseases and may affect disease progression.To investigate the performance of controlled attenuation parameter (CAP) for diagnosis hepatic patients with autoimmune (AILDs).Patients who were suspected having AILDs underwent biopsy consistently enrolled. Liver stiffness measurement (LSM) CAP performed by transient elastography. The area under receiver operating characteristic (AUROC) curve was used to evaluate diagnosing compared...