Scott G. Harroun

ORCID: 0000-0003-3370-5341
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About
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Research Areas
  • Advanced biosensing and bioanalysis techniques
  • Advanced Nanomaterials in Catalysis
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Carbon and Quantum Dots Applications
  • Nanocluster Synthesis and Applications
  • Nanoplatforms for cancer theranostics
  • Electrochemical sensors and biosensors
  • Biosensors and Analytical Detection
  • Graphene and Nanomaterials Applications
  • Ocular Surface and Contact Lens
  • Electrochemical Analysis and Applications
  • Mass Spectrometry Techniques and Applications
  • Tryptophan and brain disorders
  • Luminescence and Fluorescent Materials
  • Phytochemicals and Antioxidant Activities
  • Influenza Virus Research Studies
  • Quantum Dots Synthesis And Properties
  • Curcumin's Biomedical Applications
  • Nanoparticle-Based Drug Delivery
  • Alkaline Phosphatase Research Studies
  • Ionic liquids properties and applications
  • Identification and Quantification in Food
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Crystallization and Solubility Studies
  • Selenium in Biological Systems

Polytechnique Montréal
2022-2024

Université de Montréal
2015-2023

Département de Chimie Moléculaire
2018-2021

National Taiwan University
2015-2017

Saint Mary's University
2011-2014

University of Saint Mary
2014

We have developed a one-step method to synthesize carbon quantum dots (CQDPAs) from biogenic polyamines (PAs) as an antibacterial agent for topical treatment of bacterial keratitis (BK). CQDs synthesized by direct pyrolysis spermidine (Spd) powder through simple dry heating exhibit solubility and yield much higher than those putrescine spermine. demonstrate that obtained Spds (CQDSpds) possess effective activities against non-multidrug-resistant Escherichia coli, Staphylococcus aureus,...

10.1021/acsnano.7b01023 article EN ACS Nano 2017-07-05

Photoluminescent gold nanodots (Au NDs) are prepared via etching and codeposition of hybridized ligands, an antimicrobial peptide (surfactin; SFT), 1‐dodecanethiol (DT), on nanoparticles (≈3.2 nm). As‐prepared ultrasmall SFT/DT–Au NDs (size ≈2.5 nm) a highly efficient agent. The photoluminescence properties stability as well the activity dependent density SFT Au NDs. Relative to SFT, exhibit greater activity, not only nonmultidrug‐resistant bacteria but also multidrug‐resistant bacteria....

10.1002/adfm.201503248 article EN Advanced Functional Materials 2015-10-23

This study reports a two‐step method to synthesize spermidine‐capped fluorescent carbon quantum dots (Spd–CQDs) and their potential application as an antibacterial agent. Fluorescent (CQDs) are synthesized by pyrolysis of ammonium citrate in the solid state then modified with spermidine simple heating treatment without coupling Spermidine, naturally occurring polyamine, binds DNA, lipids, proteins involved many important processes within organisms such DNA stability, cell growth,...

10.1002/adhm.201600297 article EN Advanced Healthcare Materials 2016-07-22

Poly(catechin)-capped gold nanoparticles carrying amfenac exhibit superior anti-inflammatory/anti-oxidative properties for rapid recovery from dry eye.

10.1039/c9nr00376b article EN Nanoscale 2019-01-01

Effective infectious keratitis treatment must eliminate the pathogen, reduce inflammatory response, and prevent persistent damage to cornea. Infectious is generally treated with broad-spectrum antibiotics; however, they have risk of causing corneal epithelial cell drug resistance. In this study, we prepared a nanocomposite (Arg-CQDs/pCur) from arginine (Arg)-derived carbon quantum dots (Arg-CQDs) polymeric curcumin (pCur). Partial carbonization hydrochloride in solid state by mild pyrolysis...

10.1021/acsami.3c04316 article EN ACS Applied Materials & Interfaces 2023-05-29

A simple, portable electrochemical surface-enhanced Raman spectroscopy (SERS) system is reported, consisting of a small benchtop spectrometer, laptop computer, and USB potentiostat. Screen printed electrodes modified with silver colloidal nanoparticles are used as the SERS-active electrode, which exhibit long-term stability once prepared. Spectroelectrochemical analyses para-aminothiophenol melamine model systems was conducted. In both cases, an increase in SERS signal observed upon...

10.1021/ac2030078 article EN Analytical Chemistry 2011-12-27

Treatment using Au/BiOI nanocomposites for <italic>S. aureus</italic>-infected bacterial keratitis revealed that the are an effective agent ocular infections.

10.1039/c8nr00800k article EN Nanoscale 2018-01-01

Cyanide Hitches a Ride is by-product of the biosynthesis ethylene in plants and it has been somewhat puzzling how ion safely removed before can shut down enzymatic pathways by coordination to catalytic iron centers. A proposed mechanism implicated cyanoformate ion—essentially, weak adduct cyanide carbon dioxide—as initial product, although its lifetime was uncertain. Murphy et al. (p. 75 ; see Perspective Alabugin Mohamed ) crystallized this previously elusive found that solution-phase...

10.1126/science.1250808 article EN Science 2014-04-03

Many serious public health emergencies around the globe are caused by viral epidemics. Thus, developing a reliable method for screening is in high demand. Multiplex assays simultaneous detection and fast of high-risk pathogens especially needed. This study employs metal nanoparticles to generate specific mass spectral signals different RNA viruses, which enables whole viruses laser desorption/ionization spectrometry (LDI-MS). We developed nanoparticle-based sandwich immunosorbent assay as...

10.1021/acssensors.9b00054 article EN ACS Sensors 2019-05-08

Abstract Sepsis is a life‐threatening condition that can progress to septic shock as the body's extreme response pathogenesis damages its own vital organs. Staphylococcus aureus ( S. ) accounts for 50% of nosocomial infections, which are clinically treated with antibiotics. However, methicillin‐resistant strains (MRSA) have emerged and withstand harsh antibiotic treatment. To address this problem, curcumin (CCM) employed prepare carbonized polymer dots (CPDs) through mild pyrolysis. Contrary...

10.1002/smll.202307210 article EN Small 2024-01-26

The demand for methods and technologies capable of rapid, inexpensive continuous monitoring health status or exposure to environmental pollutants persists. In this work, the development novel surface-enhanced Raman spectroscopy (SERS) substrates from metal-coated silk fabric, known as zari, presents potential SERS be incorporated into clothing other textiles routine important analytes, such disease biomarkers pollutants. Characterization zari fabric was completed using scanning electron...

10.1039/c4an01633e article EN The Analyst 2014-11-24

The enzyme-like activity of bismuth oxyiodide nanonetworks are tunable by <italic>in situ</italic> deposition with metal or oxide nanoparticles and the doped can selective detect Hg<sup>2+</sup> Pb<sup>2+</sup> ions.

10.1039/c6qm00149a article EN Materials Chemistry Frontiers 2016-12-07

Using polyamines as the initial organic raw material and by applying simple pyrolysis methods, super cationic carbon quantum dots (CQDs) can easily be made. Since are natural products synthesis procedure is green, these polyamine-derived CQDs display low toxicity high biocompatibility but possess antibacterial activity. In addition, other unique properties, such facilitation of wound healing passage through tight junction, which make them a very promising bactericide in future clinical applications.

10.1021/acsinfecdis.7b00150 article EN ACS Infectious Diseases 2017-09-21
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