A5088574776- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Alzheimer's disease research and treatments
- Cannabis and Cannabinoid Research
- Nerve injury and regeneration
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Nuclear Receptors and Signaling
- MicroRNA in disease regulation
- Ginkgo biloba and Cashew Applications
- Autophagy in Disease and Therapy
- Forensic Toxicology and Drug Analysis
- Cancer, Hypoxia, and Metabolism
- Biochemical Analysis and Sensing Techniques
- Neurological Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Olfactory and Sensory Function Studies
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
National Institute of Pharmaceutical Education and Research
2018-2025
Masaryk University
2023-2025
International Clinical Research Center, St. Anne's University Hospital Brno
2022-2025
St. Anne's University Hospital Brno
2022-2025
University Hospital Brno
2022-2025
National Clinical Research
2025
Central European Institute of Technology
2014-2022
Central European Institute of Technology – Masaryk University
2014-2022
Inserm
2015
Université Clermont Auvergne
2015
Diabetic wounds are one of the debilitating complications that affect up to 20% diabetic patients. Despite advent extensive therapies, recovery rate is unsatisfactory, and approximately, 25% patients undergo amputation, thereby demanding alternative therapeutic strategies. On basis individual roles miR-155 inhibitor mesenchymal stem cells (MSC)-derived exosomes, we conjectured combination MSC-derived exosomes would have synergy in wound healing. Herein, miR-155-inhibitor-loaded showed...
Cisplatin resistance is one of the major concerns in treatment oral squamous cell carcinoma (OSCC). Accumulating evidence suggests microRNA (miRNA) dysregulation as mediators chemoresistance. Toward this, our previous study revealed role exosomal microRNA-155 (miR-155) cisplatin via downregulation FOXO3a, a direct target miR-155, and induction epithelial-to-mesenchymal transition OSCC. In present study, we demonstrate therapeutic potential miR-155 inhibitor-laden exosomes sensitization...
Parkinson's disease (PD) is a progressive neurodegenerative with no permanent cure affecting around 1% of the population over 65. There an urgency to search for disease-modifying agent fewer untoward effects. PD pathology involves accumulation toxic alpha-synuclein (α-syn) and neuronal inflammation leading degeneration dopaminergic (DAergic) neurons. Swertiamarin (SWE), well-studied natural product, possesses strong anti-inflammatory effect. It secoiridoid glycoside isolated from Enicostemma...
Background: Signal Transducer and Activator of Transcription 3 (STAT3) is an identified critical protein associated with the progression cancer.Alpha mangostin (α-M), a powerful dietary xanthone found to have anticancer properties against various cancers.However, precise mechanism its anti-cancer activity not fully understood.Therefore, current work hypothesized that targeting STAT3 α-M inhibits migration, invasion, proliferation breast cancer cells.Firstly, we evaluated binding affinity...
Background: Parkinson's disease (PD) is intricately linked to gastrointestinal inflammation and the presence of neurotoxins in gut, integrating α-syn pathologic alterations subsequent neurodegeneration into brain. Objectives: This study aimed explore enduring impact dextran sodium sulfate (DSS)-mediated colitis on vulnerability central dopaminergic neurons rotenone exposure. Methods: To induce chronic colitis, 10-month-old C57BL/6 mice were pre-exposed 3 cycles 1 week 1% (w/v) DSS...
Accumulation of misfolded α-synuclein (α-Syn) leads to the formation Lewy bodies and is a major hallmark Parkinson's disease (PD). The accumulation α-Syn involves several post-translational modifications. Recently, though, glycation (advanced end products) activation receptor for advanced products (RAGE) have been linked neuroinflammation, which oxidative stress α-Syn. present study aims detect effect glycated (gly-α-Syn)-induced synucleinopathy loss dopaminergic (DAergic) neurons in...
Previous studies have demonstrated that caffeine administration to adult mice potentiates glial activation induced by 3,4-methylenedioxymethamphetamine (MDMA). As neuroinflammatory response seems correlate with neurodegeneration, and the young brain is particularly vulnerable neurotoxicity, we evaluated dopamine neuron degeneration in caudate-putamen (CPu) substantia nigra pars compacta (SNc) of adolescent mice. Mice were treated MDMA (4 × 20 mg/kg), alone or (10 mg/kg). Interleukin (IL)-1β,...
Parkinson's disease (PD) is one of the most common progressive neurodegenerative pathologies that leads to dopaminergic deficiency and motor manifestations. Alpha-synuclein aggregation a characteristic hallmark PD pathogenesis. These aggregates facilitate formation Lewy bodies degeneration. The epidemiological evidence demonstrates definitive association diabetes with risk. Considering this, many antidiabetic agents such as GLP-1 agonists DPP-4 inhibitors are being explored alternative...
Malondialdehyde (MDA), a major reactive byproduct of lipid peroxidation, has been implicated in numerous pathological conditions as result altering the structure and function crucial proteins. One such protein is α-synuclein (α-Syn), which plays vital role pathogenesis Parkinson's disease (PD). This study investigates hypothesis that MDA causes structural alterations α-Syn, promoting its aggregation exacerbating toxicological effects. In vivo experiments were conducted where MDA-modified...