A5014423163- Curcumin's Biomedical Applications
- Retinoids in leukemia and cellular processes
- Advanced Breast Cancer Therapies
- Nanoparticle-Based Drug Delivery
- Cancer-related Molecular Pathways
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- Flavonoids in Medical Research
Tabriz University of Medical Sciences
2017-2019
Islamic Azad University Medical Branch of Tehran
2017-2019
Nanoparticle (NP)-based combinational chemotherapy has been proposed as a potent approach for improving intracellular drug concentrations and attaining synergistic effects in colorectal cancer therapy. Here, two well-known herbal substances, Curcumin (Cur) Chrysin (Chr), were co-encapsulated PEGylated PLGA NPs investigated their inhibitory effect against Caco-2 cells. Characterization of nanoformulated drugs was determined using DLS, FTIR, TEM, SEM. Drug release study performed dialysis...
The study was aimed at investigating the synergistic inhibitory effect of unique combinational regimen nanocapsulated Metformin (Met) and Curcumin (Cur) against T47D breast cancer cells. For this purpose, Met Cur were co-encapsulated in PEGylated PLGA nanoparticles (NPs) evaluated for their therapeutic efficacy. morphology dynamic light scattering (DLS) analyses carried out to optimize nanoformulations. Drug release performed using dialysis method then cytotoxic individual combined drugs on...