A5036760612- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Congenital heart defects research
- Craniofacial Disorders and Treatments
- Marine animal studies overview
- Cancer-related molecular mechanisms research
- Congenital gastrointestinal and neural anomalies
- Hedgehog Signaling Pathway Studies
- Single-cell and spatial transcriptomics
- Noise Effects and Management
- Animal Vocal Communication and Behavior
Chinese University of Hong Kong
2022-2025
California Institute of Technology
2025
University of Hong Kong
2022-2024
The transcription factor Lmx1a is widely expressed during early inner ear development, and mice lacking expression exhibit fusion of cochlear vestibular hair cells fail to form the ductus reuniens endolymphatic sac. dreher (Lmx1a dr/dr ), a recessive null mutation, results in non-functional expression, which expands from outer sulcus stria vascularis Reissner's membrane. In absence Lmx1a, we observe lack proteins specific vascularis, such as BSND KCNQ1 marginal CD44 intermediate cells....
A common cause of deafness in humans is dysregulation the endocochlear potential generated by stria vascularis (SV). Thus, proper formation SV critical for hearing. Using single-cell transcriptomics and a series Shh signaling mutants, we discovered that receptor Patched1 (Ptch1) essential marginal cell (MC) differentiation formation. Single-cell RNA sequencing analyses revealed cochlear roof epithelium already specified into discrete domains with distinctive gene expression profiles at...
Development of mammalian auditory epithelium, the organ Corti, requires precise control both cell cycle withdrawal and differentiation. Sensory progenitors (prosensory cells) in cochlear apex exit first but differentiate last. Sonic hedgehog (Shh) signaling is required for spatiotemporal regulation prosensory differentiation, underlying mechanisms remain unclear. Here, we show that suppressor fused (Sufu), a negative regulator Shh signaling, essential controlling timing progression hair (HC)...
Abstract The mammalian inner ear houses the vestibular and cochlear sensory organs dedicated to sensing balance sound, respectively. These distinct arise from a common prosensory region, but mechanisms underlying their divergence remain elusive. Here, we showed that two evolutionarily conserved homeobox genes, Irx3 Irx5 , are required for patterning segregation of saccular domains, as well formation auditory cells. Irx3/5 were highly expressed in cochlea, deletion resulted significantly...
A gene cadre orchestrates the normal development of sensory and non-sensory cells in inner ear, segregating cochlea with a distinct tonotopic sound frequency map, similar brain projection, five vestibular end-organs. However, role genes driving ear is largely unknown. Here, we show double deletion Iroquois homeobox 3 5 transcription factors (Irx3/5 DKO) leads to fusion saccule cochlear base. The overlying otoconia tectorial membranes are absent Irx3/5 DKO primary auditory neurons project...