A5002020134- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- Nanoplatforms for cancer theranostics
- Pancreatic function and diabetes
- Diabetes Management and Research
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Photodynamic Therapy Research Studies
- 3D Printing in Biomedical Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced biosensing and bioanalysis techniques
- Diabetes and associated disorders
- Graphene and Nanomaterials Applications
- Protein Interaction Studies and Fluorescence Analysis
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Advanced Nanomaterials in Catalysis
- Microfluidic and Bio-sensing Technologies
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Advanced Sensor and Energy Harvesting Materials
Zhejiang University
2021-2025
Jinhua Academy of Agricultural Sciences
2022-2025
Sir Run Run Shaw Hospital
2022-2025
Dalian Minzu University
2012-2023
Zhejiang Chinese Medical University
2022
Zhejiang Lab
2022
Synthetic Genomics (United States)
2020-2021
University of North Carolina at Chapel Hill
2015-2020
North Carolina State University
2015-2020
Zen Bio (United States)
2019-2020
Significance For exploiting synthetic glucose-responsive insulin delivery systems, challenges remain to demonstrate a strategy that would combine ( i ) fast responsiveness, ii ease of administration, and iii excellent biocompatibility. We have developed novel device using painless microneedle-array patch containing hypoxia-sensitive hyaluronic acid-based vesicles. The vesicles quickly dissociate release encapsulated under the local hypoxic environment, caused by enzymatic oxidation glucose...
A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen (1O2) and inducing hypoxia to promote release of its cargoes in tumor cells, leading enhanced antitumor efficacy. This dual-responsive provides an innovative design guideline enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug-release modality. As service our authors readers, this journal supporting information supplied by the...
A self-regulated “smart” insulin administration system would be highly desirable for diabetes management. Here, a glucose-responsive delivery device, which integrates H2O2-responsive polymeric vesicles (PVs) with transcutaneous microneedle-array patch was prepared to achieve fast response, excellent biocompatibility, and painless administration. The PVs are self-assembled from block copolymer incorporated polyethylene glycol (PEG) phenylboronic ester (PBE)-conjugated polyserine (designated...
Although cancer immunotherapy based on immune checkpoint inhibitors holds great promise toward many types of cancers, several challenges still remain, associated with low objective response patient rate as well systemic side effects. Here, a combination strategy is developed thermogelling reactive oxygen species (ROS)-responsive polypeptide gel for sustained release anti-programmed cell death-ligand 1 antibody and dextro-1-methyl tryptophan, inhibitor indoleamine-2,3-dioxygenase leveraging...
A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity without long-term side effect has the potential to improve diabetic patients' health and quality of life. Here, we developed a novel device using painless microneedle-array patch containing insulin-loaded vesicles. Formed by self-assembly hypoxia H2O2 dual-sensitive diblock copolymer, polymersome-based vesicles (d-GRPs) can disassociate subsequently release triggered generated during glucose oxidation...
A bioinspired glucose-responsive insulin delivery system for self-regulation of blood glucose levels is desirable improving health and quality life outcomes patients with type 1 advanced 2 diabetes. Here we describe a painless core-shell microneedle array patch consisting degradable cross-linked gel smart rapid responsiveness excellent biocompatibility. This gel-based device can partially dissociate subsequently release when triggered by hydrogen peroxide (H2O2) generated during the...
Mechanical force-based stimulus provides a simple and easily accessible manner for spatiotemporally controlled drug delivery. Here we describe wearable, tensile strain-triggered delivery device consisting of stretchable elastomer microgel depots containing loaded nanoparticles. By applying strain to the film, release from microdepot is promoted due enlarged surface area diffusion Poisson's ratio-induced compression on microdepot. Correspondingly, both sustained by daily body motions...
An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation. One MN patch can quickly reduce blood-sugar levels (BGLs) chemically induced type-1 diabetic mice and stabilize BGLs at a reduced level over 10 h.
Obesity is one of the most serious public health problems in 21st century that may lead to many comorbidities such as type-2 diabetes, cardiovascular diseases, and cancer. Current treatments toward obesity including diet, physical exercise, pharmacological therapy, well surgeries are always associated with low effectiveness or undesired systematical side effects. In order enhance treatment efficiency minimized effects, we developed a transcutaneous browning agent patch locally induce adipose...
Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well inappropriate dosing timing in distinct stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed dynamically modulate immune microenvironment according varied phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at early stage via generating reactive oxygen species...
Insulin and glucagon secreted from the pancreas with dynamic balance play a vital role in regulating blood glucose levels. Although distinct glucose-responsive insulin delivery systems have been developed, lack of self-regulated release module limits their clinical applications due to potential risk hypoglycemia. Here, we describe transdermal polymeric microneedle patch for closed-loop achieve glycemic regulation minimized The phenylboronic acid units can bind reversibly shift net charge...
Phototherapy of deep tumors still suffers from many obstacles, such as limited near-infrared (NIR) tissue penetration depth and low accumulation efficiency within the target sites. Herein, stimuli-sensitive tumor-targeted photodynamic nanoparticles (STPNs) with persistent luminescence for treatment are reported. Purpurin 18 (Pu18), a porphyrin derivative, is utilized photosensitizer to produce in STPNs, while lanthanide-doped upconversion (UCNPs) exhibit bioimaging properties possess high...
Glucose-responsive delivery of insulin mimicking the function pancreatic β-cells to achieve meticulous control blood glucose (BG) would revolutionize diabetes care. Here authors report development a new glucose-responsive system based on potential interaction between derivative-modified (Glc-Insulin) and transporters erythrocytes (or red cells, RBCs) membrane. After being conjugated with glucosamine, can efficiently bind RBC membranes. The binding is reversible in setting hyperglycemia,...
Abstract Anaerobic bacteria, such as Clostridium and Salmonella , can selectively invade colonize in tumor hypoxic regions (THRs) deliver therapeutic products to destroy cancer cells. Herein, we present an anaerobe nanovesicle mimic that not only be activated THRs but also induce hypoxia tumors by themselves. Moreover, inspired the oxygen metabolism of anaerobes, construct a light‐induced hypoxia‐responsive modality promote dissociation vehicles activation bioreductive prodrugs...
Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially large remain elusive. Here, we exploit a new strategy to form micro-sized complex between charge-switchable polymer glucose-sensing moiety and driven by electrostatic interaction. Both high loading efficiency (95%) capacity (49%) can be achieved. In the presence of hyperglycemic state, glucose-responsive phenylboronic acid (PBA) binds glucose instantly converts charge...