A5059985975- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Trace Elements in Health
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Ferrocene Chemistry and Applications
- Chaos control and synchronization
- Opinion Dynamics and Social Influence
- Complex Network Analysis Techniques
- Quantum chaos and dynamical systems
- Nonlinear Dynamics and Pattern Formation
- Peer-to-Peer Network Technologies
- Carbon and Quantum Dots Applications
- DNA and Nucleic Acid Chemistry
- Fullerene Chemistry and Applications
- Peptidase Inhibition and Analysis
- Graphene and Nanomaterials Applications
- Signaling Pathways in Disease
- Protein Degradation and Inhibitors
- Extracellular vesicles in disease
Institute of Biophysics
2019-2025
Chinese Academy of Sciences
2008-2025
University of Chinese Academy of Sciences
2019-2025
Czech Academy of Sciences, Institute of Biophysics
2025
Stanford University
2010
Ningbo University
2008
Chinese Academy of Agricultural Mechanization Sciences
2008
The use of catalase-like nanozymes in relieving tumor hypoxia has been a promising strategy for adjuvant radiotherapy, yet their catalytic mechanism and toxic potential remain elusive. While most studies on mechanisms focus the substrates products process, little is reported to analyze dominating surface structure activity nanozymes. Here, we ferrihydrite revealed its structure-activity relationship. Among ten main forms iron oxide nanomaterials, ferrihydrite, especially 2-line exhibited...
RNA interference (RNAi) represents a promising gene-specific therapy against tumors. However, its clinical translation is impeded by poor performance of lysosomal escape and tumor targeting. This challenge especially prominent in glioblastoma (GBM) therapy, necessitating the penetration blood-brain barrier (BBB). Leveraging intrinsic tumor-targeting BBB traversing capability human H-ferritin, we designed series ferritin variants with positively charged cavity truncated carboxyl terminus,...
Ferritin is endowed with a unique structure and the ability to self-assemble. Besides, genetic manipulation can easily tune functions of ferritin nanocages, which further expands biomedical applications ferritin.
Owing to their attractive antitumor effects, aminated fullerene derivatives are emerging as promising therapeutic drugs for cancer. However, in vivo applications severely limited due cation toxicity. To address this problem, human heavy chain ferritin (HFn), possessing natural biocompatibility is utilized, develop a novel supramolecular assembly drug delivery system. Specifically, tetra[4-(amino)piperidin-1-yl]-C
<title>Abstract</title> Lysosome-targeted chimeras (LYTACs) have emerged as promising therapeutic agents because of their ability to degrade pathogenesis-related proteins. However, the current LYTAC systems often require considerable effort for individual construction and are devoid a convenient efficient modular platform. Here, we developed human heavy chain ferritin (HFn)-based platform by harnessing its unique protein cage structure capacity endocytosis into lysosomes via tumor-specific...
Abstract Artificial nanorobot is a type of robots designed for executing complex tasks at nanoscale. The system typically consisted four systems, including logic control, driving, sensing and functioning. Considering the subtle structure functionality nanorobot, manufacture nanorobots requires designable, controllable multi-functional nanomaterials. Here, we propose that nanozyme promising candidate fabricating due to its unique properties, flexible designs, enzyme-like activities,...
In this paper, a function projective synchronization scheme is developed to investigate the between discrete-time driven chaotic system and response system. With aid of symbolic-numeric computation, we use study 2D Lorenz Hénon system, as well that 3D hyperchaotic Hénon-like map via three scalar controllers, respectively. Moreover numerical simulations are used verify effectiveness proposed scheme.