A5081081999- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Trace Elements in Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Ischemia and Reperfusion
- Alzheimer's disease research and treatments
- Ferroptosis and cancer prognosis
- Ecology and Conservation Studies
- Genomics, phytochemicals, and oxidative stress
- Cardiac Arrest and Resuscitation
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Hydrogen embrittlement and corrosion behaviors in metals
- Nanocluster Synthesis and Applications
- Muscle Physiology and Disorders
- Gold and Silver Nanoparticles Synthesis and Applications
- Muscle metabolism and nutrition
- Plant Diversity and Evolution
- Plant tissue culture and regeneration
- Cardiovascular and exercise physiology
- Epigenetics and DNA Methylation
- Amoebic Infections and Treatments
- S100 Proteins and Annexins
Affiliated Hospital of Youjiang Medical University for Nationalities
2019-2024
Chiang Mai University
2020-2022
Thailand Center of Excellence in Physics
2021
Nanjing Forestry University
2017
Jilin University
2017
First Bethune Hospital of Jilin University
2014
Cognitive impairment has been reported in patients with myocardial infarction despite a successful reperfusion therapy. Several modes of cell death are involved brain damage during cardiac ischemia/reperfusion (I/R) injury. Although apoptosis, necroptosis, and ferroptosis inhibitors provided neuroprotection against cerebral I/R injury, the effects these on following injury have never investigated. We hypothesized that attenuate One-hundred twenty-six male rats were used: 6 assigned to sham...
Abstract Growing evidence demonstrated that cell death pathways including ferroptosis, apoptosis and necroptosis contribute to cardiac ischaemia/reperfusion (I/R) injury. We hypothesized differently myocardial damage during acute I/R Rats underwent or sham operation. I/R‐operated rats were divided into 4 groups: vehicle, (Z‐vad), ferroptosis (Fer‐1) (Nec‐1) inhibition. in each inhibitor group subdivided 3 different dose regimens: low, medium high. Infarct size, left ventricular (LV)...
Abstract Gd 3+ ‐aggregated gold nanoclusters (AuNCs) encapsulated by silica shell (Gd ‐A‐AuNCs@SiO 2 NPs) were strategically designed and prepared. The as‐prepared nanoparticles exhibit aggregation‐enhanced fluorescence (AEF), with an intensity that is up to 3.8 times of discrete AuNCs. clusters served as novel nanoprobes for in vitro vivo multimodal (fluorescence, magnetic resonance, computed X‐ray tomography) cancer imaging
Liriodendron is a genus of the magnolia family comprised two flowering tree species that produce hardwoods great ecological and economic value. However, only limited amount genetic research has been performed on partly because transient or stable transgenic trees have difficult to produce. In general, expression systems are indispensable for rapid, high-throughput screening systematic characterization gene functions at low cost; therefore, development such system would provide necessary step...
In order to improve therapy for head and neck squamous cell carcinoma (HNSCC), biomarkers associated with local and/or distant tumor relapses cancer drug resistance are urgently needed. This study identified a potential biomarker, Bcl-2 athanogene-1 (BAG-1), that is implicated in HNSCC insensitive cisplatin progression. Primary advanced (relapsed from parental) University of Michigan lines were tested sensitivity gene expression profiles compared between primary (cisplatin sensitive) the...
<title>Abstract</title> Background Nasopharyngeal carcinoma (NPC) is a highly invasive form of head and neck cancer that arises from nasopharyngeal epithelial cells. The treatment advanced NPC with radiotherapy presents significant challenges due to cellular resistance, which has spurred interest in natural small molecule drugs. Celastrol curcumin, both derived plants, have exhibited anti-tumor properties. However, the clinical development celastrol hindered by its low bioavailability...
Introduction: Brain inflammation and microglial hyperactivation are involved in the process of neuronal death including apoptosis, necroptosis, ferroptosis, following cardiac cerebral ischemia/reperfusion (I/R) injury. However, roles these cell inhibitors on brain microglia I/R injury have not been investigated. Hypothesis: Inhibitors necroptosis ferroptosis effectively attenuate rats with Methods: Rats were subjected to either sham or operation (30 min-ischemia followed by 120-min...
Introduction: Apoptosis and ferroptosis have been implicated in cardiac ischemia/reperfusion (I/R) injury. Inhibitors of apoptosis (Z-VAD) (FER-1) shown to protect the heart several cardiovascular disorders. However, impacts Z-VAD, FER-1, combined therapy during I/R injury not elucidated. Hypothesis: Z-VAD FER-1 provide cardioprotection by reducing myocardial cell improving function. The treatment exerts better benefits than either single regimen. Methods: Male rats (n=25) were equally...
Recently, several studies have reported the incidence of cognitive impairments in patients with acute myocardial infarction and heart failure. Mechanistically, dendritic spine loss hippocampus, due to oxidative stress/inflammation induced apoptosis, is proposed as one responsible mechanisms underlying impairments. However, effects z-vad, which an apoptosis inhibitor, on brain pathologies following cardiac ischemia/reperfusion (I/R) injury never been investigated. We hypothesized that z-vad...