A5047452431- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Cellular Mechanics and Interactions
- Nanofabrication and Lithography Techniques
- Advanced Drug Delivery Systems
- Polymer Surface Interaction Studies
- Tissue Engineering and Regenerative Medicine
- Microfluidic and Capillary Electrophoresis Applications
- Neuroscience and Neural Engineering
- Nanoparticle-Based Drug Delivery
- Anodic Oxide Films and Nanostructures
- RNA Interference and Gene Delivery
- Diabetes Management and Research
- Diabetes and associated disorders
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Orthopaedic implants and arthroplasty
- Electrohydrodynamics and Fluid Dynamics
- Nanowire Synthesis and Applications
- Orthopedic Infections and Treatments
- Biomedical and Engineering Education
University of California, San Francisco
2016-2025
Brown University
1993-2025
Smt. N.H.L. Municipal Medical College
2025
Institute for Medical Biology
2025
John Brown University
2025
Nova Southeastern University
2024-2025
University of California, Berkeley
2015-2024
Providence College
2023-2024
Drexel University
2023
American Institute for Medical and Biological Engineering
2023
We report for the first time fabrication of self-aligned hexagonally closed-packed titania nanotube arrays over 1000 μm in length and aspect ratio ≈10 000 by potentiostatic anodization titanium. describe a process which such thick array films can be transformed into self-standing, flat or cylindrical, mechanically robust, polycrystalline TiO2 membranes precisely controlled nanoscale porosity. The self-standing are characterized using Brunauer−Emmett−Teller surface area measurements, glancing...
A biosensor application of vertically coupled glass microring resonators with Q/spl sim/12 000 is introduced. Using balanced photodetection, very high signal to noise ratios, and thus sensitivity refractive index changes (limit detection 1.8/spl times/10/sup -5/ units), are achieved. Ellipsometry X-ray photoelectron spectroscopy results indicate successful modification surfaces. Experimental data obtained separately for a bulk change the medium avidin-biotin binding on ring surface reported....
Nanotubes for drug release: Titania nanotubes (see image) fabricated by an easy anodization process can be used as drug-eluting coatings implantable devices. The release rate of the drugs is controlled varying amount proteins loaded into nanotubes. Moreover, changing nanotube diameter, wall thickness, and length, kinetics altered each specific to achieve a sustained release.
Abstract Tissue engineering approaches have the potential to increase physiologic relevance of human iPS-derived cells, such as cardiomyocytes (iPS-CM). However, forming Engineered Heart Muscle (EHM) typically requires >1 million cells per tissue. Existing miniaturization strategies involve complex not amenable mass production, limiting ability use EHM for iPS-based disease modeling and drug screening. Micro-scale cardiospheres are easily produced, but do facilitate assembly elongated...
Effective drug delivery is important in the treatment of various biomedical conditions, ranging from autoimmune disorders to cancer and bacterial infections. Nanostructured systems can help overcome challenges efficient such as poor distribution, inefficient penetration across biological barriers off-target effects. The bioinspired nanotopography carrier surfaces provides a physical cue modulate their interaction with systems. In this Review, we discuss how naturally occurring...
Abstract Tumors exhibit an increased ability to obtain and metabolize nutrients. Here, we implant engineered adipocytes that outcompete tumors for nutrients show they can substantially reduce cancer progression, a technology termed adipose manipulation transplantation (AMT). Adipocytes use amounts of glucose fatty acids by upregulating UCP1 were placed alongside cells or xenografts, leading significant suppression. Transplanting modulated organoids in pancreatic breast genetic mouse models...
MIC end points for the most commonly prescribed azole antifungal drug, fluconazole, can be difficult to determine because its fungistatic nature lead excessive "trailing" of growth during susceptibility testing by National Committee Clinical Laboratory Standards broth macrodilution and microdilution methods. To overcome this ambiguity, fluconazole acts inhibiting ergosterol biosynthesis, we developed a novel method differentiate fluconazole-susceptible from fluconazole-resistant isolates...
The pathophysiology of neurally mediated syncope is poorly understood. It has been widely assumed that excessive sympathetic activation in a setting left ventricular hypovolemia stimulates afferents trigger hypotension and bradycardia. We tested this hypothesis by determining if precedes development syncope, correlates with alterations baroreflex function. studied the changes intraarterial blood pressure (BP), heart rate (HR), central venous (CVP), muscle nerve activity (MSNA), plasma...
The development of suitable three-dimensional matrices for the maintenance cellular viability and differentiation is critical applications in tissue engineering cell biology. structure composition extracellular matrix (ECM) has been shown to modulate behavior with respect shape, movement, proliferation, differentiation. Although collagen chitosan have separately proposed as vitro ECM materials, influence chitosan--collagen composite on morphology, differentiation, function not well studied....