A5025038021- Optical Imaging and Spectroscopy Techniques
- Hemodynamic Monitoring and Therapy
- Extracellular vesicles in disease
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Liver Disease and Transplantation
- Non-Invasive Vital Sign Monitoring
- MicroRNA in disease regulation
- Anesthesia and Sedative Agents
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Intraoperative Neuromonitoring and Anesthetic Effects
- Ubiquitin and proteasome pathways
- Hip and Femur Fractures
- Esophageal and GI Pathology
- Pain Management and Opioid Use
- Renal cell carcinoma treatment
- Anesthesia and Pain Management
- MRI in cancer diagnosis
- COVID-19 diagnosis using AI
- Abdominal Surgery and Complications
Icahn School of Medicine at Mount Sinai
2019-2023
Mount Sinai Medical Center
2023
Drexel University
2015-2017
Mutations in TERT (telomerase reverse transcriptase) promoter are established gatekeepers early hepatocarcinogenesis, but little is known about other molecular alterations driving this process. Epigenetic deregulation a critical event malignancies. Thus, we aimed to (1) analyze DNA methylation changes during the transition from preneoplastic lesions HCC (eHCC) and identify candidate epigenetic gatekeepers, (2) assess prognostic potential of cirrhotic tissue.Methylome profiling was performed...
Surveillance tools for early cancer detection are suboptimal, including hepatocellular carcinoma (HCC), and biomarkers urgently needed. Extracellular vesicles (EVs) have gained increasing scientific interest due to their involvement in tumour initiation metastasis; however, most extracellular RNA (exRNA) blood-based biomarker studies limited annotated genomic regions.
Cancer testis antigens (CTAs) are an extensive gene family with a unique expression pattern restricted to germ cells, but aberrantly reactivated in cancer tissues. Studies indicate that the (or re-expression) of CTAs within MAGE-A is common hepatocellular carcinoma (HCC). However, no systematic characterization has yet been reported. The aim this study perform comprehensive profile CTA de-regulation HCC and experimentally evaluate role MAGEA3 as driver progression. transcriptomic analysis 44...
With 15 drugs currently approved for the treatment of metastatic renal cell carcinoma (mRCC) and even more combination regimens with immunotherapy on horizon, there remains a distinct lack molecular biomarkers therapeutic efficacy. Our study reports real-world clinical outcomes mRCC patients from tertiary academic medical center treated empirically selected standard-of-care therapy. We utilized Stanford Renal Cell Carcinoma Database (RCCD) to report various outcome measures, including...
<h3>Importance</h3> Thirty-day readmission rates have been suggested as a marker for quality of care. By investigating the factors associated with readmissions in all otolaryngology subspecialties we provide data relevant development risk stratification systems to improve outcomes. <h3>Objective</h3> To establish association surgical and hospital volume patient characteristics 30-day guide otolaryngology-specific models. <h3>Design, Setting, Participants</h3> A retrospective cohort study...
The anesthetic concerns of patients undergoing robotic-assisted laparoscopic radical prostatectomy (RALP) are primarily related to the use pneumoperitoneum in steep Trendelenburg position. This combination will affect cerebrovascular, ocular, respiratory, and hemodynamic homeostasis. Possible non-surgical complications range from mild subcutaneous emphysema devastating ischemic optic neuropathy. management RALP involves a thorough preoperative evaluation, careful positioning on operative...
Anesthesia monitoring currently needs a reliable method to evaluate the effects of anesthetics on its primary target, brain. This study focuses investigating clinical usability functional near-infrared spectroscopy (fNIRS)-derived machine learning classifier perform automated and real-time classification maintenance emergence states during sevoflurane anesthesia. For 19 surgical procedures, we examine entire continuum maintenance-transition-emergence phases predictive capability support...
To describe demographic, clinical, and lung base CT findings in COVID-19 patients presenting with abdominal complaints. In this retrospective study, 76 who underwent for complaints from March 1 to April 15, 2020, a large urban multihospital Health System were included. Those positive (n = 14) then excluded, 62 undergoing final analysis (30M/32F; median age 63 years, interquartile range (IQR) 52–75 30–90 years). Demographic clinical data extracted. assessment was performed by cardiothoracic...
ABSTRACT Background Hepatocellular carcinoma (HCC) is among the deadliest malignancies and surveillance tools for early detection are suboptimal. Extracellular vesicles (EVs) have gained increasing scientific interest due to their involvement in tumor initiation metastasis, however, most extracellular RNA (exRNA) biomarker studies limited annotated genomic regions. Methods EVs were isolated with ultracentrifugation nanoDLD quality assessed by electron microscopy, immunoblotting, nanoparticle...
Abstract Hepatocellular carcinoma (HCC) is the tumor with highest increase in incidence and mortality last 20 years. Exosomes are nano-sized particles loaded nucleic acids proteins involved cell-to-cell communication. The aims of this study are: 1) to establish a method isolate exosomes from plasma HCC patients, 2) detect de-regulated transcripts patients compared controls. In pilot study, we included 10 5 controls at high-risk development (i.e. cirrhosis and/or chronic hepatitis B). Plasma...
Abstract Epigenetic deregulation is a critical event in human malignancies. Besides mutations TERT promoter, found 20% of dysplastic nodules, little known about the key molecular alterations driving early hepatocarcinogenesis. The aims this study were: 1) to analyze DNA methylation changes during transition from preneoplastic lesions hepatocellular carcinoma (HCC), and 2) identify candidate epigenetic gatekeepers between dysplasia tumors. Methylome profiling was done with Illumina...
Epigenetic deregulation is a critical event in human malignancies. Besides mutations TERT promoter, found 20% of dysplastic nodules, little known about the key molecular alterations driving early hepatocarcinogenesis. The aims this study were: 1) to analyze DNA methylation changes during transition from preneoplastic lesions hepatocellular carcinoma (HCC), and 2) identify candidate epigenetic gatekeepers between dysplasia tumors.Methylome profiling was done with Illumina HumanMethylation450...
Hepatocellular carcinoma (HCC) is the tumor with highest increase in incidence and mortality last 20 years. Exosomes are nano-sized particles loaded nucleic acids proteins involved cell-to-cell communication. The aims of this study are: 1) to establish a method isolate exosomes from plasma HCC patients, 2) detect de-regulated transcripts patients compared controls.In pilot study, we included 10 5 controls at high-risk development (i.e. cirrhosis and/or chronic hepatitis B). Plasma were...