A5001838079- Protein Structure and Dynamics
- Enzyme Structure and Function
- SARS-CoV-2 and COVID-19 Research
- Bioinformatics and Genomic Networks
- Yersinia bacterium, plague, ectoparasites research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Mass Spectrometry Techniques and Applications
- Photosynthetic Processes and Mechanisms
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
Italian Institute of Technology
2022-2024
Abstract What are the molecular determinants of protein–protein binding affinity and whether they similar to those regulating fold stability two major questions biology, whose answers bring important implications both from a theoretical applicative point view. Here, we analyze chemical physical features on large dataset complexes with reliable experimental data compare them set monomeric proteins for which melting temperature was available. In particular, probed spatial organization protein...
Abstract Antibody light chain amyloidosis is a disorder in which protein aggregates, mainly composed of immunoglobulin chains, deposit diverse tissues impairing the correct functioning organs. Interestingly, due to high susceptibility antibodies mutations, AL appears be strongly patient‐specific. Indeed, every patient will display their own mutations that make proteins involved prone aggregation thus hindering study this disease on wide scale. In framework, determining molecular mechanisms...
The continuous emergence of novel variants represents one the major problems in dealing with SARS-CoV-2 virus. Indeed, also due to its prolonged circulation, more than ten concern emerged, each time rapidly overgrowing current viral version improved spreading features. As, up now, all carry at least mutation on spike Receptor Binding Domain, stability binding between protein and human ACE2 receptor seems molecular determinants behind potential. In this framework, a better understanding...
Abstract The prolonged circulation of the SARS‐CoV‐2 virus resulted in emergence several viral variants, with different spreading features. Moreover, increased number recovered and/or vaccinated people introduced a selective pressure toward variants able to evade immune system, developed against former versions. This process results reinfections. Aiming study latter process, we first collected large structural dataset antibodies complex original version Spike protein. We characterized...