ABSTRACT Background Malignant tumors release growth factors, promoting lymphangiogenesis in primary and draining sentinel lymph nodes, ultimately facilitating node metastasis. As a malignant lymphatic tumor entity, lymphangiosarcomas are characterized by low survival rates limited treatment options. The transcription factor SOX18 plays crucial role both endothelial cell differentiation cancer‐induced lymphangiogenesis. Aims In this vitro study, we investigated the potential therapeutic...

Background: Regenerative matrices are essential in the therapy of complex wounds, where lymphangiogenesis and angiogenesis play crucial roles. This work investigates lymph- angiogenic potential regenerative scaffolds influence adipose-derived mesenchymal stem cells (ADSC) a rodent wound model. Methods: In model, we administered different Acellular Dermal Matrices (ADMs) to two wounds on each rat—enriching one with ADSCs leaving other without. were isolated from inguinal fat tissue,...

The conventional approach of looking down a microscope to perform microsurgical procedures is associated with occupational injuries, anti-ergonomic postures, and increased tremor fatigue, all which predispose microsurgeons early retirement. Recently, three-dimensional (3D) visualization real-time magnification has been developed as an alternative. Despite its commercial availability, no supermicrosurgical have reported using this technology date. Lymphovenous anastomoses (LVAs) often require...

Secondary lymphedema (SL) affects 120 million people globally, posing a lifelong burden for up to 37% of cancer survivors. Chronic inflammation and progressive fibrosis are key drivers SL, yet detailed characterization immune cell subpopulations across stages is lacking. This study aimed investigate the immunologic profile lymphedematous skin its association with extracellular matrix changes, which could serve as clinical biomarkers or therapeutic targets.

Hybrid breast reconstruction (HBR) combines silicone implants with fat grafting to improve implant coverage, treating local tissue deficiencies and leading a more natural appearance. Recent data also indicated less capsular contracture after HBR. The authors developed novel technique animal model of cell-assisted (CA) HBR illuminate its effects on contracture.Animals received in dorsal submuscular pocket. Although animals the group around without stem cell enrichment, rats CA-HBR1 CA-HBR2...

Secondary lymphedema (SL)is a frequent and devastating complication of modern oncological therapy filarial infections. A lack reliable preclinical model to investigate the underlying mechanism clinical stage progression has limited development new therapeutic strategies. Current first line treatment shown be merely symptomatic relies on lifetime use compression garments decongestive physiotherapy. In this study, we present secondary in 35 rats using pre- intraoperative fluorescence-guided...

Abstract For nearly two decades, Negative Pressure Wound Therapy (NPWT) has been used for temporary wound coverage as well bed preparation. The addition of instillation and dwell time an adjunct to NPWT (NPWTi‐d) enables cleaning improved granulation. Thirty patients with different types colonised wounds (traumatic, surgical, chronic) were treated NPWTi‐d using saline instillation. Patient data, microbiological data characteristics collected analysed. Endpoints bacterial decontamination...

Introduction Severe thermal trauma to the hand can result in major impairment and reduced function due defective healing or even extremity loss. Full-thickness injuries frequently incur exposure of tendons bone require an early stable coverage with soft tissue transplants allow for rapid induction exercise preserve structures function. Free transfer after is a rare indication, safety, management, outcome free flap surgery severe acute burn remains underreported. Methods Patients primary...

Abstract Background Risk stratification, economic pressure, and a flat learning curve make the realization development of proper microsurgical skills competences challenging task in daily clinical practice. In previous studies, we were able to show that procedures, e.g., free flaps replantations, are safe training procedures teachable practice view certain issues risk stratification. The present study aims evaluate further improvements terms safety complication rates for as procedure after...

Abstract Background Microsurgery is an indispensable tool of upper extremity reconstruction addressing defect coverage and the restoration function. Perioperative anticoagulation antiplatelet therapy are controversially discussed with impact on microsurgical outcome, but without clear evidence. This study aims to evaluate perioperative in reconstruction. Methods All eligible patients treated between January 2000 July 2014 were included a comparative analysis define superior regime...

The driver of secondary lymphedema (SL) progression is chronic inflammation, which promotes fibrosis. Despite advances in preclinical research, a specific effector cell subpopulation as biomarker for therapy response or stage still missing SL. Whole skin samples 35 murine subjects microsurgically induced SL model and 12 patients with were collected their fibroblasts isolated. These lymphedema-associated (LAFs) cultured collagen I-poly-D-lysine 3-dimensional hydrogel to mimic conditions....

Conducting research during specialty training provides an opportunity to develop critical thinking and leadership skills along with a better understanding of the scientific literature. However, trainees often find it difficult undertake research, in context labor-intensive surgical training. The aim this study is evaluate output limitations plastic surgery residents different countries.An international cross-sectional involving recent postgraduates from Brazil, Chile, Germany, United Kingdom...

Abstract Background Post-surgical abdominal and inguinal scars are a frequent challenge in plastic surgery. There limited non-invasive alternatives to address depressed retracted scars. The associated retraction fibrosis might cause lymphatic dysfunction with subsequent regional edema. authors describe combined surgical approach of liposuction, the use dissecting cannulas, lipofilling, Scarpa’s fascia suspension sutures prospective case series. Methods proposed procedure was performed 22...