A5020703427- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Physiological and biochemical adaptations
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- T-cell and B-cell Immunology
- Caveolin-1 and cellular processes
- Pediatric health and respiratory diseases
- Cell Adhesion Molecules Research
- Neurobiology and Insect Physiology Research
- MicroRNA in disease regulation
- Clusterin in disease pathology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Extracellular vesicles in disease
- Erythrocyte Function and Pathophysiology
- Allergic Rhinitis and Sensitization
- Circadian rhythm and melatonin
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Respiratory Support and Mechanisms
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Food Allergy and Anaphylaxis Research
Nanjing Medical University
2018-2023
Jiangsu Province Hospital
2018-2023
First Hospital of Jiaxing
2019
Bronchial epithelial cell damage occurs in patients with bronchial asthma. Ezrin, a membrane-cytoskeleton protein, maintains cellular morphology and intercellular adhesion protects the barrier function of cells.To study role ezrin cells injury correlate its expression asthma severity.Levels were measured exhaled breath condensate (EBC) serum BAL fluid (BALF) from mouse model by ELISA. The regulation IL-13 on protein levels was studied primary cells. Ezrin knockdown using shRNA human 16HBE...
Abstract Background Allergen source‐derived proteases are a critical factor in the formation and development of asthma. The cysteine protease activity house dust mite (HDM) disrupts epithelial barrier function. expression cystatin SN (CST1) is elevated asthma epithelium. CST1 inhibits activity. We aimed to elucidate role epithelium‐derived caused by HDM. Methods protein levels sputum supernatants serum patients with healthy volunteers were measured ELISA. ability suppress HDM‐induced...
Exosomal microRNAs (exo-miRNAs or miRs) have demonstrated diagnostic value in various diseases. However, their chronic obstructive pulmonary disease (COPD) has yet to be fully established. The purpose of the present study was screen differentially expressed exo-miRNAs plasma patients with COPD and healthy individuals evaluate potential COPD. Differentially controls were identified using high-throughput sequencing confirmed reverse transcription-quantitative PCR (RT-qPCR). Bioinformatics...
Abstract Background Asthma is characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. Airway results from enhanced smooth muscle (ASM) contraction potentially under the control of an epithelium‐derived relaxing factor (EpDRF). However, relatively rare known about EpDRF. We aimed to elucidate role stanniocalcin‐1 (STC1) on AHR ASM contraction. Methods Stanniocalcin‐1 levels in serum asthmatic patients healthy volunteers bronchoalveolar lavage fluid (BALF) ovalbumin...
PIEZO1, a mechanosensitive ion channel protein, has been identified in the correlation between several cancers. However, systematic pancancer study of PIEZO1 still lacks. We examined across thirty-three types cancers to explore its role prognosis and immunological function for first time. Based on open databases TCGA, GTEx CPTAC, demonstrated be differentially expressed most compared adjacent normal tissues. The distinct tumor patients was explored by GEPIA2. Genetic alteration TCGA tumors...
Objective To analyze the dynamic changes of serum M30 and M65 levels in patients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) during artificial support system(ALSS) therapy, to explore their predictive efficiency clinical values for short-term prognosis HBV-ACLF. Methods Seventy-six HBV-ACLF who underwent ALSS therapy first time from May 2016 2019 First Hospital Jiaxing were selected.The divided into improvement group (38 cases) non-recovered...