A5068924231- Legume Nitrogen Fixing Symbiosis
- Ion channel regulation and function
- Neonatal Health and Biochemistry
- Mosquito-borne diseases and control
- Chemical Synthesis and Analysis
- Lipid Membrane Structure and Behavior
- Receptor Mechanisms and Signaling
- Supramolecular Chemistry and Complexes
- Bacterial Genetics and Biotechnology
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Chemical Analysis and Environmental Impact
- Neuroscience of respiration and sleep
- Nicotinic Acetylcholine Receptors Study
- Polyamine Metabolism and Applications
- Advanced biosensing and bioanalysis techniques
- Protein Structure and Dynamics
- Neuroscience and Neuropharmacology Research
- Electrochemical Analysis and Applications
- Chemical Reactions and Isotopes
Forschungszentrum Jülich
2007-2015
Heinrich Heine University Düsseldorf
2009-2011
Cyclic nucleotide-sensitive ion channels, known as HCN and CNG are activated by binding of ligands to a domain (CNBD) located on the cytoplasmic side channel. The underlying mechanisms not well understood. To elucidate gating mechanism, structures both ligand-free -bound CNBD required. Several crystal from HCN2 bacterial channel (MloK1) have been solved. However, for HCN2, cAMP-free state did reveal substantial structural rearrangements. For MloK1, information has only gained mutant CNBDs....
Background Dengue virus (DENV) is a mosquito-transmitted positive single strand RNA belonging to the Flaviviridae family. DENV causes dengue fever, currently world's fastest-spreading tropical disease. Severe forms of disease like hemorrhagic fever and shock syndrome are life-threatening. There no specific treatment anti-DENV vaccines. Our recent data suggests that amino terminal cytoplasmic region non-structural protein 4A (NS4A) comprising acid residues 1 48 an amphipathic helix in...