A5036730920- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Connexins and lens biology
- Retinal and Macular Surgery
- Medical Practices and Rehabilitation
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Photoreceptor and optogenetics research
- Biomedical and Chemical Research
- Neuroscience and Neuropharmacology Research
- Ophthalmology and Eye Disorders
- S100 Proteins and Annexins
- Neurological Disorders and Treatments
- Political Economy and Marxism
- Medical and Health Sciences Research
- Calpain Protease Function and Regulation
- Social Policy and Reform Studies
- Botulinum Toxin and Related Neurological Disorders
- Cell Adhesion Molecules Research
- Blood Coagulation and Thrombosis Mechanisms
- Parasitic Diseases Research and Treatment
- German Literature and Culture Studies
- melanin and skin pigmentation
Technische Universität Dresden
2012-2022
University Hospital Carl Gustav Carus
2011-2022
Marymount University
2022
Creative Commons
2022
Masaryk University
2019
Goethe University Frankfurt
2013-2015
Friedrich-Alexander-Universität Erlangen-Nürnberg
1996-2006
Ludwig-Maximilians-Universität München
2002-2005
University of Freiburg
1997
Anna University, Chennai
1994-1997
<h3>Background/Aims:</h3> To evaluate the retinal toxicity of Brilliant Blue G (BBG) following intravitreal injection in rat eyes and examine biocompatibility staining properties humans. <h3>Methods:</h3> BBG was injected into 11 to toxic effects with balanced salt solution (BSS) serving as control. Retinal assessed by ganglion cell (RGC) counts light microscopy 7 days later. In addition, applied during vitrectomy for macular hole (MH) (n = 15) or epiretinal membranes (ERM) 3) a prospective,...
Lymphatic vessel endothelial hyaluronic acid receptor (LYVE-1) is a newly discovered lymphatic endothelium-specific marker that also expressed by subpopulation of macrophages. To date, there no report on its expression in the posterior human uvea. The purpose this study was to investigate LYVE-1 normal choroids.Eyes body/cornea donors (55-89 years age; 4-9 hours postmortem) were obtained. Choroids dissected and prepared for cryosections followed immunohistochemistry with anti-human antiserum...
To judge the information of experimental settings in relation to human situation, it is crucial be aware morphological differences and peculiarities species studied. Related glaucoma, most important structures posterior eye segment are optic nerve head including lamina cribrosa, inner retinal layers. The review highlights cribrosa its vascular supply, prelaminar head, ganglion cell layer widely used animal models for glaucoma research, mouse, rat, rabbit, pig, dog, cat, chicken, quail....
Dedifferentiation of retinal pigment epithelial (RPE) cells is a crucial event in the pathogenesis proliferative vitreoretinopathy (PVR). This study was designed to improve understanding RPE cell dedifferentiation vitro. The protein expression pattern native differentiated compared with that cultured, thereby dedifferentiated, cells.Differentiated human and monolayers dedifferentiated cultured primary were processed for two-dimensional (2-D) electrophoresis. Total cellular proteins separated...
Helminth infections in humans and animals are associated with strong T helper 2 (Th2) responses. To determine whether parasite-derived Ag preferentially expand a Th2-like cell population, filter immunoplaque assay was used to enumerate the frequencies (F0) of PBMC CD4(+)-enriched from individuals helminth secreting selected cytokines response (PAg) nonparasite antigens (NPAg). In 20 lymphatic filariasis, frequency analysis IL-4 IFN-gamma indicated that F0 PAg-specific IL-4-secreting cells...
Tissue inhibitor of metalloprotease (TIMP)-3 is an matrix (MMP) and regulates angiogenesis. In the eye, TIMP3 tightly associated with Bruch's membrane. this study, authors analyzed mice lacking for retinal abnormalities.Mice targeted disruption Timp3 gene were generated (Timp3(-/-)) bred into C57/Bl6 CD1 backgrounds. Eyes by light electron microscopy. Vasculature was examined scanning laser ophthalmoscopy, corrosion casts, whole mount preparations. MMP activity assessed in situ zymography,...
Immunohistochemical staining of choroidal whole mounts as well serial tangential sections and electron-microscopic investigation 21 human donor eyes revealed a network nonvascular alpha-smooth-muscle-actin-positive cells (NVSMC) in the entire choroid most densely arranged posterior part suprachoroid submacular region. Ultrastructurally these present typical structure myofibroblasts. Double labeling with desmin smooth muscle myosin showed positive reaction only few cells. Posteriorly NVSMC...
To characterize further non-vascular smooth muscle cells (NVSMC) in the choroid of human eye, extensive morphological studies were performed including a three-dimensional distribution NVSMC adult eye and their appearance during development. Whole mounts sections through sclera eyes 42 donors (between 13th week gestation 89 years age) stained with antibodies against actin other markers for cells. On basis localization, three groups could be distinguished eyes: (a) semicircular arrangement...
To evaluate systematically the staining characteristics and safety of potential new dyes for intraocular surgery.Six were included in investigation: light green SF (LGSF) yellowish, E68, bromophenol blue (BPB), Chicago (CB), rhodamine 6G, rhodulinblau-basic 3 (RDB-B3). All dissolved diluted a balanced saline solution. The light-absorbing properties each dye measured at concentration 0.05% between 200 1000 nm. Staining examined by lens capsule tissue epiretinal membranes (ERMs), removed...
purpose. To characterize human choroidal ganglion cells (CGCs) further, regarding their immunohistochemical and ultrastructural appearance pre- postsynaptic connections. methods. Choroidal wholemounts serial sections of donor eyes were stained with antibodies against neuronal nitric oxide synthase (nNOS), vasoactive intestinal peptide (VIP), tyrosine hydroxylase (TH), vesicular monoaminergic transporter (VMAT)-2, acetylcholine (VAChT), neuropeptide Y (NPY), substance P (SP), calcitonin...
Primary splenic angiosarcoma is an extremely rare and aggressive vascular neoplasm associated with high rates of metastasis. A male patient in his 70s presented thrombocytopenia. Physical examination blood tests were non-revealing. large lesion was found on imaging, splenectomy confirmed the diagnosis angiosarcoma. PET scan brain MRI showed no evidence The now under surveillance imaging. presents a significant clinical challenge due to its nature nonspecific symptoms, outcomes typically poor...
To investigate the effect of intravitreal injections new vital dyes on retina, retinal pigment epithelium (RPE) and choroid in an vivo rat model.Rats were injected intravitreally with four dyes: light-green SF yellowish (LGSF), copper(II)phthalocyanine-tetrasulfonic acid (E68), bromphenol blue (BPB), Chicago (CB) dissolved physiologic saline solution (PSS) at concentrations 0.5% 0.02%. PSS served as control. Additional animals treated single 0.5%, 0.02%, 0.002%, 0.0002% ICG or 0.002% E68...
To investigate the intraocular effect of rhodamine 6G (R6G) on retinal structures and function in an vivo rat model to develop method for accurate evaluation new dyes surgery.R6G physiologic saline solution (PSS) was injected into vitreous adult Brown Norway rats at concentrations 0.0002%, 0.002%, 0.02%, 0.2%, 0.5%. Control animals received only PSS. Retinal toxicity assessed by ganglion cell (RGC) counts, light microscopy 7 days later, photopic electroretinography (ERG), measurement...