A5033724279- Cancer Mechanisms and Therapy
- Synthesis and Biological Evaluation
- Peptidase Inhibition and Analysis
- Plant Molecular Biology Research
- Multiple Myeloma Research and Treatments
- Synthesis and biological activity
- Plant Reproductive Biology
- Ubiquitin and proteasome pathways
- Cancer therapeutics and mechanisms
- Photosynthetic Processes and Mechanisms
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
- Light effects on plants
- Toxin Mechanisms and Immunotoxins
- Plant Stress Responses and Tolerance
- Chronic Lymphocytic Leukemia Research
- Plant Parasitism and Resistance
- Viral-associated cancers and disorders
- Plant Genetic and Mutation Studies
- Chromosomal and Genetic Variations
- PARP inhibition in cancer therapy
Instytut Hematologii i Transfuzjologi
2020-2023
Centre for Omic Sciences
2022-2023
Centre for Plant Biotechnology and Genomics
2016-2018
Universidad Politécnica de Madrid
2016-2018
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
2016-2018
Warsaw University of Life Sciences
2016
Abstract The family of PIM serine/threonine kinases includes three highly conserved oncogenes, PIM1, PIM2, and PIM3, which regulate multiple prosurvival pathways cooperate with other oncogenes such as MYC. Recent genomic CRISPR-Cas9 screens further highlighted oncogenic functions PIMs in diffuse large B-cell lymphoma (DLBCL) cells, justifying the development small-molecule inhibitors therapeutic targeting lymphomas. However, detailed consequences inhibition DLBCL remain undefined. Using...
Intricate gene regulatory networks orchestrate biological processes and developmental transitions in plants. Selective transcriptional activation silencing of genes mediate the response plants to environmental signals cues. Therefore, insights into mechanisms that control plant expression are essential gain a deep understanding how regulated The chromatin immunoprecipitation (ChIP) technique described here is procedure identify DNA-binding sites proteins or genomic regions model species...
Intricate gene regulatory networks orchestrate biological processes and developmental transitions in plants. Selective transcriptional activation silencing of genes mediate the response plants to environmental signals cues. Therefore, insights into mechanisms that control plant expression are essential gain a deep understanding how regulated The chromatin immunoprecipitation (ChIP) technique described here is procedure identify DNA-binding sites proteins or genomic regions model species...
Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin in adults, exhibiting highly heterogenous clinical behavior and complex molecular background. In addition to genetic complexity, different DLBCL subsets exhibit phenotypic features independent of For example, a subset DLBCLs distinguished by increased oxidative phosphorylation unique transcriptional features, including overexpression certain mitochondrial genes chaperone, heat shock protein HSP90α...
In January 2016, the first Epigenetic and Chromatin Regulation of Plant Traits conference was held in Strasbourg, France. An all-star lineup speakers, a packed audience 130 participants from over 20 countries, friendly scientific atmosphere contributed to make this meeting remember. article we summarize some new insights into chromatin, epigenetics, epigenomics research highlight nascent ideas emerging concepts exciting area research.
<div>Abstract<p>The family of PIM serine/threonine kinases includes three highly conserved oncogenes, <i>PIM1, PIM2,</i> and <i>PIM3</i>, which regulate multiple prosurvival pathways cooperate with other oncogenes such as <i>MYC</i>. Recent genomic CRISPR-Cas9 screens further highlighted oncogenic functions PIMs in diffuse large B-cell lymphoma (DLBCL) cells, justifying the development small-molecule inhibitors therapeutic targeting lymphomas....
<p>Supplemental Materials</p>
<p>Supplemental Materials</p>
<div>Abstract<p>The family of PIM serine/threonine kinases includes three highly conserved oncogenes, <i>PIM1, PIM2,</i> and <i>PIM3</i>, which regulate multiple prosurvival pathways cooperate with other oncogenes such as <i>MYC</i>. Recent genomic CRISPR-Cas9 screens further highlighted oncogenic functions PIMs in diffuse large B-cell lymphoma (DLBCL) cells, justifying the development small-molecule inhibitors therapeutic targeting lymphomas....