A5061330066- Amyotrophic Lateral Sclerosis Research
- CRISPR and Genetic Engineering
- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- Genetics, Aging, and Longevity in Model Organisms
- Adenosine and Purinergic Signaling
- Neurobiology and Insect Physiology Research
- Cholinesterase and Neurodegenerative Diseases
- Pancreatic function and diabetes
- Chromosomal and Genetic Variations
- Nerve injury and regeneration
- European and International Law Studies
- Mast cells and histamine
- Prion Diseases and Protein Misfolding
- Olfactory and Sensory Function Studies
- Folate and B Vitamins Research
- Fungal and yeast genetics research
- Conflict of Laws and Jurisdiction
- DNA Repair Mechanisms
- Pluripotent Stem Cells Research
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- European Criminal Justice and Data Protection
- Neurological disorders and treatments
Fondazione Santa Lucia
2020-2024
Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti
2024
National Research Council
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Sapienza University of Rome
2020-2023
Several mutations in the SOD1 gene encoding for antioxidant enzyme Superoxide Dismutase 1, are associated with amyotrophic lateral sclerosis, a rare and devastating disease characterized by motor neuron degeneration patients' death within 2–5 years from diagnosis. Motor loss related symptomatology manifest mostly adult life and, to date, there is still gap of knowledge on precise cellular molecular events preceding neurodegeneration. To deepen our awareness early phases disease, we leveraged...
Abstract Vitamin B6 is a water-soluble vitamin which possesses antioxidant properties. Its catalytically active form, pyridoxal 5’-phosphate (PLP), crucial cofactor for DNA and amino acid metabolism. The inverse correlation between cancer risk has been observed in several studies, although dietary intake sometimes failed to confirm this association. However, the molecular link remains elusive. Previous work shown that deficiency causes chromosome aberrations (CABs) Drosophila human cells,...
Huntington's disease (HD) is an autosomal dominant disorder with progressive motor dysfunction and cognitive decline. The caused by a CAG repeat expansion in the
The present work intends to provide a closer look at histamine in Drosophila. This choice is motivated firstly because Drosophila has proven over the years be very simple, but powerful, model organism abundantly assisting scientists explaining not only normal functions, also derangements that occur higher organisms, excluding humans. Secondly, been demonstrated pleiotropic master molecule pharmacology and immunology, with increasingly recognized roles nervous system. Indeed, it interacts...
OPINION article Front. Pharmacol., 24 July 2020Sec. Experimental Pharmacology and Drug Discovery Volume 11 - 2020 | https://doi.org/10.3389/fphar.2020.01148
Abstract The insulin signaling pathway controls cell growth and metabolism, thus its deregulation is associated with both cancer diabetes. Phosphatidylinositol 3‐kinase (PI3K) contributes to the cascade of phosphorylation events occurring in by activating protein kinase B (PKB/AKT), which phosphorylates several substrates, including those involved glucose uptake storage. PI3K inactivating mutations are resistance while identified human cancers. Here we show that RNAi‐induced depletion...
Maturity-onset diabetes of the young (MODY) type 2 is caused by heterozygous inactivating mutations in gene encoding glucokinase (GCK), a pivotal enzyme for glucose homeostasis. In pancreas GCK regulates insulin secretion, while liver it promotes utilization and storage. We showed that silencing DrosophilaGCK orthologs Hex-A Hex-C results MODY-2-like hyperglycemia. Targeted knock-down revealed expressed producing cells (IPCs) whereas specifically fat body. essential secretion required...
Huntington’s disease (HD) is a life-threatening neurodegenerative disorder. Altered levels and functions of the purinergic ionotropic P2X7 receptors (P2X7Rs) have been found in animal cellular models HD, suggesting their possible role pathogenesis disease; accordingly, therapeutic potential P2X7R antagonists HD has proposed. Here we further investigated effects ligands vitro ex vivo experimental models. In ST14A/Q120 rat striatal cells, reduction expression; however, agonist...
This study attempts to verify what concretely the Grimaldi doctrine entails for national courts. According this landmark decision, a court is bound take European soft law into account when adjudicating disputes. Although more than 30 years have passed since its adoption, role in domestic legal order still appears ambiguous. In hope of highlighting Court had meant state, paper intends grasp real implications leading case. First, outline scope duty enshrined by Court, some aspects will be...
The NSC-34 cell line is a widely recognized motor neuron model and various neuronal differentiation protocols have been exploited. Under previously reported experimental conditions, only part of the cells resemble differentiated neurons; however, they do not exhibit extensive time-prolonged neuritogenesis, maintain their duplication capacity in culture. aim present work was to facilitate long-term more homogeneous neuron–like cells. We found that antimitotic drug cytosine arabinoside...
Abstract Huntington’s disease (HD) is a late-onset, autosomal dominant disorder characterized by progressive motor dysfunction, cognitive decline and psychiatric disturbances. The most prominent pathological manifestation selective loss of medium-sized spiny neurons the striatum. caused CAG repeat expansion in IT15 gene, which elongates stretch polyglutamine at amino-terminal HD protein, Huntingtin (Htt). Despite accumulation an impressive amount data on molecular basis neurodegeneration, no...