A5055447568- Pluripotent Stem Cells Research
- Planarian Biology and Electrostimulation
- Plant and Biological Electrophysiology Studies
- Epigenetics and DNA Methylation
- Marine Ecology and Invasive Species
- Family Support in Illness
- Congenital heart defects research
- TGF-β signaling in diseases
- Pulmonary Hypertension Research and Treatments
- Genetics and Neurodevelopmental Disorders
- Angiogenesis and VEGF in Cancer
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Ultrasound in Clinical Applications
- Hemodynamic Monitoring and Therapy
- Wound Healing and Treatments
Whitehead Institute for Biomedical Research
2021-2022
Howard Hughes Medical Institute
2021
Harvard University
2021
Massachusetts Institute of Technology
2021
Saint John Regional Hospital
2018
Harvard Stem Cell Institute
2012-2017
Brigham and Women's Hospital
2013
Massachusetts General Hospital
2012
Vascular endothelium is a dynamic cellular interface that displays unique phenotypic plasticity. This plasticity critical for vascular function and when dysregulated pathogenic in several diseases. Human genotype-phenotype studies of are limited by the unavailability patient-specific endothelial cells. To establish platform studying biology, we have generated from human induced pluripotent stem cells (iPSCs) exhibiting rich functional mature primary endothelium. These respond to diverse...
Regeneration often involves the formation of a blastema, an outgrowth or regenerative bud formed at plane injury where missing tissues are produced. The mechanisms that trigger blastema therefore fundamental for regeneration. Here, we identify gene, which named equinox, is expressed within hours in planarian wound epidermis. equinox encodes predicted secreted protein conserved many animal phyla. Following inhibition, amputated planarians fail to maintain wound-induced gene expression and...
Abstract PHF8 is a histone demethylase with specificity for repressive modifications. While mutations of have been associated cognitive defects and cleft lip/palate, its role in mammalian development physiology remains unexplored. Here, we generated Phf8 knockout allele mice to examine the consequences loss behaviour. deficient neither display obvious developmental nor signs impairment. However, report striking resiliency stress-induced anxiety- depression-like behaviour on . We further...
Planarians are flatworms and can perform whole-body regeneration. This ability involves a mechanism to distinguish between anterior-facing wounds that require head regeneration posterior-facing tail How this head-tail polarity decision is made studied identify principles underlying tissue-identity specification in We report inhibition of activin-2 , which encodes an Activin-like signaling ligand, resulted the ectopic heads following amputation. During tissue turnover uninjured planarians,...