A5087942494- Metabolism and Genetic Disorders
- Genetic diversity and population structure
- Amino Acid Enzymes and Metabolism
- Identification and Quantification in Food
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Neurological diseases and metabolism
- Metabolomics and Mass Spectrometry Studies
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Lignin and Wood Chemistry
- Chromosomal and Genetic Variations
- Biochemical and Molecular Research
- HIV Research and Treatment
- Peroxisome Proliferator-Activated Receptors
- Neuroscience and Neuropharmacology Research
- Biochemical and biochemical processes
- Folate and B Vitamins Research
- Wildlife Ecology and Conservation
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Genetic and phenotypic traits in livestock
- Wildlife Conservation and Criminology Analyses
- Clostridium difficile and Clostridium perfringens research
North-West University
2016-2025
Abstract Parrots have remarkable plumage coloration that result in part from a unique ability to produce pigments called psittacofulvins yield yellow red feather colors. Little is known about the evolution of psittacofulvin-based pigmentation. Widespread color mutations captive-bred parrots provide perfect opportunities study genetic basis this trait. An earlier on blue budgerigars, which do not possess psittacofulvins, reveals involvement an uncharacterized polyketide synthase (MuPKS)...
ABSTRACT Primary trimethylaminuria (TMAU) is characterized by systemic accumulation of trimethylamine (TMA) due to the deficient activity flavin‐containing monooxygenase 3 (FMO3). The disorder does not have detrimental pathophysiological consequences, but patients develop psychological symptoms emotionally debilitating bodily odor defined as decaying fish that affects their quality life. Here, we illustrate utility a diagnostic workup on an adolescent with primary TMAU, including biochemical...
Obsessive-compulsive disorder (OCD) is a psychiatric illness that significantly impacts affected patients and available treatments yield suboptimal therapeutic response. Recently, the role of gut-brain axis (GBA) in has emerged as potential target for exploration. However, studies concerning GBA OCD are limited. To investigate whether naturally occurring obsessive-compulsive-like phenotype rodent model, large nest building deer mice, associated with perturbations gut microbiome, we...
Abstract Background HIV-1 produces Tat, a crucial protein for transcription, viral replication, and CNS neurotoxicity. Tat interacts with TAR, enhancing HIV reverse transcription. Subtype C variants (C31S, R57S, Q63E) are associated reduced transactivation neurovirulence compared to subtype B. However, their precise impact on Tat-TAR binding is unclear. This study investigates how these substitutions affect interaction. Methods We utilized molecular modelling techniques, including MODELLER,...
Abstract Objective: Compulsive-like rigidity may be associated with hyposerotonergia and increased kynurenine (KYN) pathway activity. Conversion of tryptophan (TRP) to (KYN), which contribute hyposerotonergia, is bolstered by inflammation, could related altered gut microbiota composition. Here, we studied these mechanisms in a naturalistic animal model compulsive-like behavioural rigidity, i.e., large nest building (LNB) deer mice ( Peromyscus sp.). Methods: Twenty-four (24) normal (NNB)- 24...
Isovaleric acidemia (IVA), due to isovaleryl-CoA dehydrogenase (IVD) deficiency, results in the accumulation of isovaleryl-CoA, isovaleric acid and secondary metabolites. The increase these metabolites decreases mitochondrial energy production increases oxidative stress. This contributes neuropathological features IVA. A general assumption literature exists that glycine N-acyltransferase (GLYAT) plays a role alleviating symptoms experienced by IVA patients through formation...
A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03473-8.
In aviculture, lovebirds are considered one of the most popular birds to keep. This African parakeet is known for its range plumage colors and ease tame. Plumage variation important price-determining trait these birds, also main selection criterion breeders. Currently, no genetic screening tests traits economic importance or confirm pedigree data available any nine lovebird species. As a starting point develop tests, de novo genome Agapornis roseicollis (rosy-faced lovebird) was sequenced,...
Even though the glycine conjugation pathway was one of first metabolic pathways to be discovered, this remains very poorly characterized. The bi-substrate kinetic parameters a recombinant human N-acyltransferase (GLYAT, E.C. 2.3.1.13) were determined using traditional colorimetric method and newly developed HPLC-ESI-MS/MS method. Previous studies analyzing GLYAT, indicated random Bi-Bi and/or ping-pong mechanism. In study, hippuric acid concentrations produced by GLYAT enzyme reaction...
ABSTRACT Glycine conjugation facilitates the metabolism of toxic aromatic acids, capable disrupting mitochondrial integrity. Owing to high exposure substrates, characterization individual glycine capacity, and its regulatory factors has become increasingly important. Aspirin benzoate have been employed for this purpose; however, adverse reactions, aspirin intolerance, Reye's syndrome in children are substantial drawbacks. The goal study was investigate p ‐aminobenzoic acid (PABA) as an...
The glycine conjugation pathway in humans is involved the metabolism of natural substrates and detoxification xenobiotics. interactions between various this their competition for enzymes are currently unknown. consists a mitochondrial xenobiotic/medium-chain fatty acid: coenzyme A (CoA) ligase (ACSM2B) N-acyltransferase (GLYAT). catalytic mechanism substrate specificity both these have not been thoroughly characterised. In study, level evolutionary conservation GLYAT missense variants...