A5060341687- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Orthopedic Surgery and Rehabilitation
- Workplace Violence and Bullying
- Elbow and Forearm Trauma Treatment
- Cancer-related gene regulation
- Occupational Health and Safety Research
- Physical Activity and Health
- Bone fractures and treatments
- Obesity, Physical Activity, Diet
- Children's Physical and Motor Development
Michigan State University
2023
East Carolina University
2021-2022
University of North Carolina at Chapel Hill
2021
Abstract NSD2 is the primary enzyme responsible for dimethylation of lysine 36 histone 3 (H3K36me2), a mark associated with active gene transcription and intergenic DNA methylation. In addition to methyltransferase domain, harbors two PWWP five PHD domains believed serve as chromatin reading modules, but their exact function in regulation activity remains underexplored. Here we report first-in-class chemical probe targeting N-terminal (PWWP1) domain NSD2. UNC6934 binds potently (K d 91 ± 8...
It is important to better understand factors associated with physical activity (PA) levels in adolescents rural areas. Cross-sectional data were used obtain self-reported PA among a school-based intervention fall 2018. Demographic data, environmental variables, and cardiovascular fitness (PACER score) also measured. Analyses included two-sample t-test, ANOVA, Chi-square test, linear regression model. Participants 3799 7th graders. Male (p < 0.0001), white healthy weight 0.0001)...
A 4-year-old boy sustained an accidental self-inflicted gunshot wound to the left forearm. Radiographs revealed a comminuted mid-diaphyseal ballistic radius fracture with critical-sized bone defect. The was treated placement of flexible intramedullary nail and antibiotic cement spacer, followed by second-stage grafting open reduction internal fixation 6 weeks later. Four months after procedure, radial defect healed appropriately without complications.In this case pediatric loss, induced...