A5069442375- Reproductive Biology and Fertility
- Chronic Kidney Disease and Diabetes
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Sperm and Testicular Function
- Phagocytosis and Immune Regulation
- Pancreatic function and diabetes
- Aldose Reductase and Taurine
- Mesenchymal stem cell research
- Immune cells in cancer
- Renal Diseases and Glomerulopathies
Wenzhou Medical University
2019-2021
First Affiliated Hospital of Wenzhou Medical University
2019-2021
Testicular structural and functional impairment is a serious complication in male diabetes mellitus (DM) patients that leads to impaired fertility adulthood. In contrast other endocrine therapies, islet transplantation (IT) can effectively prevent even reverse diabetic nephropathy myocardial damage. However, whether IT alleviate diabetes-induced testicular injury remains unclear. this study, we sought investigate the effect of on A rat model was established by streptozotocin injection. DM,...
Background . Adipose-derived mesenchymal stem cells (ADMSCs) can promote healing and inhibit inflammation/immune response in local tissues, while the detailed mechanism remains unknown. Results ADMSCs peritoneal macrophages were collected from C57BL/6 mice. The culture medium (CM) (24 hours cultured) was collected. CM added to M φ system with lipopolysaccharide (LPS) or IL-4/IL-13 blank. And those cultures without adding used as controls. A series of classification markers signaling pathways...
Pancreatic cancer is a severe disease with high morbidity and mortality. However, the primary molecular mechanisms of pancreatic tumor formation progression remain unclear. The present study using sequencing technology revealed that centromere protein M (CENPM) gene was overexpressed in tissues. CENPM one components complex plays central role kinetochore assembly, mitotic chromosome segregation. biological function has yet to be determined. Hence, two effective siRNAs were designed knock...
Abnormal signaling pathways play a crucial role in the mechanisms of podocyte injury diabetic nephropathy. They also affect recovery podocytes after islet transplantation (IT). However, specific abnormalities that therapeutic effect IT on remains unclear. The purpose this study was to assess whether RhoA/ROCK/NF-κB pathway is related restoration IT. A mouse model nephropathy established vivo using streptozotocin. mice were then subsequently reared for 4 weeks determine Islet cells, CCG-1423...