A5070792955- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Neural dynamics and brain function
- Neural Networks and Applications
- Pluripotent Stem Cells Research
- Silk-based biomaterials and applications
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Blind Source Separation Techniques
- Muscle Physiology and Disorders
- Biomedical and Engineering Education
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Muscle activation and electromyography studies
Boston University
2024
University of Miami
2017-2020
American Orchid Society
2019
We report a water-soluble and non-toxic method to incorporate additional extracellular matrix proteins into gelatin hydrogels, while obviating the use of chemical crosslinkers such as glutaraldehyde.
Epilepsy is a major neurological disorder characterized by recurrent, spontaneous seizures. For patients with drug-resistant epilepsy, treatments include neurostimulation or surgical removal of the epileptogenic zone (EZ), brain region responsible for seizure generation. Precise targeting EZ requires reliable biomarkers. Spike ripples - high-frequency oscillations that co-occur large amplitude epileptic discharges have gained prominence as candidate biomarker. However, spike ripple detection...
Calcium imaging allows recording from hundreds of neurons in vivo with the ability to resolve single cell activity. Evaluating and analyzing neuronal responses, while also considering all dimensions data set make specific conclusions, is extremely difficult. Often, descriptive statistics are used analyze these forms data. These analyses, however, remove variance by averaging responses across sessions, or combinations neurons, create quantitative metrics, losing temporal dynamics activity,...
A standard culture of cardiac cells as unorganized monolayers on tissue plastic or glass does not recapitulate the architectural mechanical properties native myocardium. We investigated physical and protein cues from extracellular matrix to engineer anisotropic tissues highly aligned top microelectrode array (MEA). The MEA platform allows non-invasive measurement beating rate conduction velocity. effect different proteins was tested by using most common in heart, fibronectin gelatin, after...
Calcium imaging allows recording from hundreds of neurons
Microfluidic platform and open-source graphical user interface automates continuous dynamic culture assessment of organs-on-chips.
We report a water-soluble and non-toxic method to incorporate additional extracellular matrix proteins into gelatin hydrogels, while obviating the use of chemical crosslinkers such as glutaraldehyde. Gelatin hydrogels were fabricated using range concentrations (4%-10%) that corresponded elastic moduli approximately 1 kPa-25 kPa, respectively; substrate stiffness relevant for multiple cell types. Microbial transglutaminase was then used enzymatically crosslink layer laminin on top resulting...