Abstract Mitragyna speciosa is reported to be beneficial for the management of chronic pain and opioid withdrawal in evolving epidemic. Data on blood–brain barrier (BBB) transport mitragynine 7‐hydroxymitragynine, active compounds plant, are still lacking inconclusive. Here, we present first time rate extent 7‐hydroxymitragynine across BBB, with an investigation their post‐BBB intra‐brain distribution. We utilized vitro BBB model study permeation interaction efflux transporter P‐glycoprotein...

Guanidinium trichloroacetate (GTCA), a novel organic single crystal was grown by slow evaporation technique. The X-ray diffraction study revealed that the GTCA belongs to tetragonal system with space group P4 1 . From linear optical studies, lower cut-off wavelength of found at 257[Formula: see text]nm. luminescent showed has high degree luminescence. shot laser damage threshold is be 2.6[Formula: text]GW/cm 2 nonlinear refractive index, absorption coefficient and third-order susceptibility...

2-phenylethylaminium 5-sulfosalicylate (2PE5S) compound was successfully synthesised and single crystals were grown by slow evaporation method. High resolution X-ray diffraction analysis revealed the crystal perfection of crystal. The presence functional groups 2PE5S confirmed FTIR analysis. thermal stability examined for UV–visible photoluminescence studies carried out to estimate optical transmittance, lower cut-off wavelength, band gap emission region respectively. laser damage threshold...

A novel organic single crystal of p -toluidinium salicylate (PTSA) was grown by slow evaporation solution growth technique. The structure determined from the X-ray diffraction analysis. functional groups existing in PTSA were accomplished using Fourier transform infrared optical transparency and band gap energy estimated utilizing UV-Visible spectrum. Photoluminescence spectral studies revealed photon excitation. dielectric behavior investigated for different frequencies a room temperature...

Background: Citrus hystrix (C. hystrix), locally known as ‘limau purut,’ is Malaysia’s major commercial fruit harvest. Besides being a common ingredient in Asian cuisines, the extracted essential oil has diverse applications. The can be from peels or leaves, which could give strong aromatic properties. Objective: main purpose of this study to evaluate antibacterial activity C. by using disc diffusion method. Materials and Methods: was Clevenger apparatus hydro-distillation evaluated agar...

The title compound, C(14)H(16)N(2)O(3), belongs to a group of esters 2-oxo- and 1,2,3,4-tetra-hydro-pyrimidine-5-carboxylic acids, which exhibit wide spectrum biological activities. dihydro-pyrimidine ring adopts screw-boat conformation. crystal packing is stabilized by strong N-H⋯O weak C-H⋯O inter-molecular hydrogen bonds. An intra-molecular bond also present.

The title compound, C 17 H 12 Cl 2 O, crystallizes in a centrosymmetric space group. dihedral angle between the two benzene rings is 24.7 (1)°. crystal packing characterized by non-classical C—H...O and C—H...Cl inter- intramolecular hydrogen bonds.

An efficient method was described for the synthesis of ethyl 9-(2-fluorobenzyl)-1-phenyl-9 H-pyrido[3,4-b]indole-3-carboxylate from starting material L-tryptophan in good yield. The structure synthesised compound established by 1H-NMR, 13C-NMR, and mass spectrometry, as well single crystal X-ray diffraction analysis. screened it's vitro anticancer activity against four human carcinoma cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. results showed...

In the title compound, C15H9NO2, which is a Baylis–Hillman product, five-membered ring adopts an envelope conformation. The crystal structure stabilized by O—H⋯O inter­molecular hydrogen bonds, linking mol­ecules into pairs around center of symmetry.

In the title compound, C(18)H(22)N(2)O(3)S, pyrimidine ring is not planar. It adopts a half-chair conformation The crystal structure characterized by classical N-H⋯O and C-H⋯O inter- intra-molecular hydrogen bonds, respectively. compound exhibits wide spectrum of biological activities.

Sildenafil, tadalafil, and vardenafil are phosphodiesterase type 5 enzyme (PDE-5) inhibitors used for the treatment of male erectile dysfunction. This present study aims to investigate 55 herbal products indicated men’s sexual health from Malaysian market adulteration PDE-5 analogues. The screening identification 20 analogues in various forms (powder, capsules, tablets, pastels) were conducted using gas chromatography–electron impact-mass spectrometer (GC-EI-MS). analysis has shown that 19...

A new compound of 2,9-bis(2-fluorobenzyl)-β-carbolinium bromide, C25H19BrF2N2 has been synthesized by the decarboxylation ethyl β-carboline-3-carboxylate with 2-fluorobenzyl bromide in presence sodium hydride DMF, good yield (92%). Its structure was characterized 1H and 13C NMR, FT-IR, MS (ESI-MS) spectrum elemental analysis. Meanwhile, its crystal determined X-ray single-crystal diffraction. The is orthorhombic, space group P212121 a = 7.4788(13), b 15.548(3), c 17.386(3) Å, V 2021.7(6) Å3,...

Novel crystal 2,9-bis(2,3-difluorobenzyl)-β-carbolineum bromide, C25H17BrF4N2 was synthesised through decarboxylation of ethyl β-carboline-3-carboxylate with 2,3-difluorobenzyl bromide in the presence sodium hydride DMF, yield (81%). The structure characterized by 1H- and 13C-NMR, FT-IR, MS (ESI-MS) spectrum elemental analysis. Its determined X-ray single-crystal diffraction. is monoclinic, space group C2/c a = 21.0117(17), b 15.4135(12), c 13.0639(11) Å, β 95.4101(19) (°), V 4212.1(6) Å3, Z...

The metallation of a tripodal ligand, hydrotris(3-methyl-2-thioxo-1-imidazolyl)borate with manganese(II) salt gave an unusual title compound, [Mn(H2O)6](C12H16N6BS3)2.4H2O. presence soft donor atom in the borate moiety may be cause non-coordinating interaction metal ion. ion is coordinated six water molecules leads to distorted octahedral geometry. In crystal, cations, anions and uncoordinated are linked by intermolecular O‒H···O hydrogen bonds week O‒H···S C‒H···S interaction, generating...