A5058362608- Pancreatic function and diabetes
- Diabetes and associated disorders
- Genetics and Neurodevelopmental Disorders
- Pluripotent Stem Cells Research
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- Diabetes Management and Research
- Cancer Immunotherapy and Biomarkers
- Cannabis and Cannabinoid Research
- Immune Cell Function and Interaction
Vrije Universiteit Brussel
2021-2024
Rationale: Although promising responses are obtained in patients treated with immune checkpoint inhibitors targeting programmed death ligand 1 (PD-L1) and its receptor death-1 (PD-1), only a fraction of benefits from this immunotherapy.Cancer vaccination may be an effective approach to improve the response anti-PD-L1/PD-1 therapy.However, there is lack research on dynamics PD-L1 expression cancer vaccination.Methods: We performed non-invasive whole-body imaging visualize at different...
This study aimed to evaluate the efficacy of a purification method developed for isolating alpha, beta, and delta cells from pancreatic islets adult mice, extending its application newborn aged mice. Furthermore, it sought examine transcriptome dynamics in mouse endocrine islet throughout postnatal development validate age-related alterations within these cell populations.
Abstract Regenerating endogenous pancreatic ß-cells is a potentially curative yet currently elusive strategy for diabetes therapy. Mimicking the microenvironment of developing pancreas and leveraging vascular signals that support endocrinogenesis may promote ß-cell regeneration. We aimed to investigate whether recovery from experimental hypovascularization endocrine pancreas, achieved by modulating transgenic production VEGF-A blocker in ß-cells, could trigger mouse proliferation....