A5080568956- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Hepatitis C virus research
- COVID-19 and healthcare impacts
- Organ Transplantation Techniques and Outcomes
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Gut microbiota and health
- Genetic factors in colorectal cancer
- Cancer therapeutics and mechanisms
- Gallbladder and Bile Duct Disorders
- Viral-associated cancers and disorders
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Childhood Cancer Survivors' Quality of Life
- Colorectal Cancer Screening and Detection
- Soft tissue tumor case studies
- Clinical Nutrition and Gastroenterology
- Dietary Effects on Health
- Microscopic Colitis
- COVID-19 Pandemic Impacts
- Inflammatory Bowel Disease
Innsbruck Medical University
2013-2025
Universität Innsbruck
2020-2025
Medizinische Hochschule Hannover
2024
University Hospital Frankfurt
2024
Goethe University Frankfurt
2024
University Hospital Innsbruck
2019-2022
Kunming Medical University
2018
Faecal biomarkers, particularly calprotectin [FCAL], have become important diagnostic and monitoring tools in inflammatory bowel diseases [IBD]. As FCAL is mainly produced by neutrophils, we hypothesised that faecal lipocalin-2 [FLCN2], also expressed intestinal epithelial cells [IEC], could be beneficial specific clinical situations.We compared endoscopic activity-related correlations between FLCN2, assayed from the same sample, a cohort of 132 patients (72 Crohn's disease [CD]) 40...
Background Lenvatinib is approved as first-line treatment for patients with advanced hepatocellular carcinoma (HCC). The efficacy of lenvatinib in Caucasian real-world insufficiently defined. purpose this study was to evaluate the a multi-center cohort (ELEVATOR) from Germany and Austria. Methods A retrospective data analysis 205 treated systemic at 14 different sites conducted. Overall survival, progression free overall response rate adverse event rates were assessed analyzed. Results...
Liver transplantation (LT) is potentially curative for patients with cirrhosis and hepatocellular carcinoma (HCC). However, this procedure usually reserved early tumor stages or after successful downstaging local regional therapies. In locally advanced HCC, current guidelines recommend locoregional palliative systemic therapies Barcelona Clinic Cancer (BCLC) B C, respectively.In article, we describe a 63-year-old male patient HCC (BCLC C) hepatitis C-associated cirrhosis. Following treatment...
Immune checkpoint inhibitors (ICI) are increasingly used in patients with advanced hepatocellular carcinoma (HCC) awaiting liver transplantation (LT). However, concerns about the risk of post-transplant rejection persist. We conducted an international retrospective cohort study including 119 HCC who received ICIs prior to LT. analyzed incidence allograft rejection, graft loss, and recurrence particular focus on washout period between last ICI dose In this study, 24 (20.2%) experienced a...
COVID-19 has spread rapidly around the world. The Austrian government implemented a lockdown on 16 March to contain further of disease. We investigated effects acute upper gastrointestinal (GI) bleeding in Austria.We contacted 98 hospitals performing emergency endoscopies. were asked report GI endoscopies performed for recent hematemesis, melena, or both, and exhibiting endoscopically visible signs bleeding. study period was from 3 weeks before (calendar Week 9) after (Week 14) initiation...
Background: Immunotherapy-based combinations are currently the standard of care in systemic treatment patients with HCC. Recent studies have reported unexpectedly long survival lenvatinib (LEN), supporting its use first-line for This study aims to compare real-world effectiveness LEN atezolizumab/bevacizumab (AZ/BV). Methods: A retrospective analysis was conducted evaluate and safety frontline AZ/BV or therapy advanced HCC across 18 university hospitals Europe. Results: The included 412...
Summary Colorectal cancer (CRC) is one of the most frequent entities worldwide and a leading cause death. The disease known to develop from potentially curable, premalignant lesions over several years therefore suitable for screening procedures preventive measures. Several trials have demonstrated reduced incidence mortality in cohorts. A multitude different strategies CRC been implemented parts world. While randomized controlled studies directly comparing are still ongoing, colonoscopy...
Therapeutic options are limited for advanced, metastatic biliary tract cancer. The pivotal NAPOLI-1 trial demonstrated the superior clinical benefit of nanoliposomal irinotecan (Nal-IRI) in gemcitabine-pretreated patients with pancreatic ductal adenocarcinoma; however, antitumor activity Nal-IRI cancer is unknown. This first report describing efficacy cancer.In this multicenter retrospective cohort analysis, we identified adenocarcinoma who were treated combination 5-fluorouracil and folinic...
The majority of patients diagnosed with pancreatic cancer have inoperable disease at the time presentation. For this reason, systemic treatment is cornerstone therapy and more options for now become available than were a decade ago. In short review, we will give an overview on therapeutic landscape in 2018 briefly discuss challenging topic neoadjuvant therapy. However, there are lot unsolved questions urgent need clinical trials new therapies. conclusion, despite recent advances, remains...
Gemcitabine, first approved for medical use in 1995, is a nucleoside analogue that shows activity against variety of solid tumors. In pancreatic ductal adenocarcinoma (PDAC) gemcitabine used both adjuvant and palliative therapy. Myelosuppression, mild dyspnea fatigue are common side effects during treatment, but severe pulmonary toxicities like related pneumonitis (GRP) reported to be uncommon with incidence approximately 0.3 – 2% treated patients.
Therapieziele in der Behandlung chronisch entzündlicher Darmerkrankungen (CED) erfuhren über die Zeit einen großen Wandel vom klinischen Ansprechen Symptomfreiheit, hin zur endoskopischen, histologischen und molekularen Remission. Obgleich Symptomfreiheit aus Patientensicht essenziell, so ist es vor allem endoskopische Remission, mit einer Reduktion von Langzeitkomplikationen wie Rezidive, Krankenhausaufenthalte Operationen assoziiert ist. Für individuelle Monitorisierung sind allerdings...
Malignant peritoneal mesothelioma (MPM) is a rare tumor, which accounts for about 30% of all tumors.
Solitary fibrous tumors (SFT) represent a rare entity of vascular CNS tumors. Extracranial metastasis develops in up to 28% cases and can occur multiple organ sites, predominantly bones, lung, pleura liver 3 decades after initial diagnosis. Here we report case series three patients treated for from primary SFT at our department.