A5100605270- Vitamin D Research Studies
- Parathyroid Disorders and Treatments
- Bone health and treatments
- Bone health and osteoporosis research
- Digestive system and related health
- Growth Hormone and Insulin-like Growth Factors
- Genetic Syndromes and Imprinting
- Mass Spectrometry Techniques and Applications
- Electrolyte and hormonal disorders
- Magnesium in Health and Disease
- Estrogen and related hormone effects
- Diet and metabolism studies
- Bone Metabolism and Diseases
- Heterotopic Ossification and Related Conditions
- Vitamin K Research Studies
- Trace Elements in Health
- Biotin and Related Studies
- Muscle metabolism and nutrition
- Ion channel regulation and function
- Reproductive System and Pregnancy
- Medical Imaging and Pathology Studies
- Pharmacological Effects and Toxicity Studies
- Pancreatic function and diabetes
- Kidney Stones and Urolithiasis Treatments
- Neuroendocrine regulation and behavior
All India Institute of Medical Sciences
2015-2025
All India Institute of Medical Sciences Jodhpur
2025
Karnataka Veterinary Animal and Fisheries Sciences University
2025
Siddhartha Medical College
2025
Mayo Clinic
2015-2024
Mayo Clinic in Arizona
2012-2024
WinnMed
2012-2024
Army Hospital Research and Referral
2024
Medanta The Medicity
2024
All India Institute of Medical Sciences Raipur
2024
Dendritic cells (DCs) play a central role in regulating immune activation and responses to self. DC maturation is the outcome of antigen presentation T cells. Maturation DCs inhibited by physiological levels 1α,25 dihydroxyvitamin D 3 [1α,25(OH) 2 ] related analog, 1α,25(OH) -16-ene-23-yne-26,27-hexafluoro-19-nor-vitamin (D analog). Conditioning bone marrow cultures with 10 −10 M analog resulted accumulation immature reduced IL-12 secretion without induction transforming growth factor β1....
Abstract Survival of critically unwell patients has improved in the last decade due to advances critical care medicine. Some these survivors develop cognitive, psychiatric and /or physical disability after treatment intensive unit (ICU), which is now recognized as post syndrome (PICS). Given limited awareness about PICS medical faculty this aspect often overlooked may lead reduced quality life cause a lot suffering their families. Efforts should be directed towards preventing by minimizing...
In 100 patients with various types of endocrine dysfunction, we measured bone mineral density (BMD) at the midradius (greater than 95% cortical bone) and distal radius (75% 25% trabecular by single photon absorptiometry lumbar spine 66% using new technique dual absorptiometry. BMD in each disorder deviated least one site from sex-specific age regression 187 normal subjects. For primary hyperparathyroidism, hypercortisolism, hyperthyroidism this deviation was negative (suggesting loss),...
Calcium absorption decreases with aging, particularly after age 70 yr. We investigated the possibility that this was due to abnormal vitamin D metabolism by studying 10 normal premenopausal women (group A), 8 postmenopausal within 20 yr of menopause B), elderly C), and hip fracture D) whose ages (mean +/- SD) were 37 4, 61 6, 78 4 yr, respectively. For all subjects, serum 25-hydroxyvitamin [25(OH)D] did not decrease age, but 1,25-dihydroxyvitamin [1,25(OH)2D], physiologically active...
Plasma 1,25-dihydroxyvitamin D levels are elevated in early pregnancy and continue to increase throughout pregnancy. They remain postpartum lactating women. The probably represent a physiological response increased calcium requirements.
Muscle weakness and myopathy are observed in vitamin D deficiency chronic renal failure, where concentrations of the active D3 metabolite, 1α,25-dihydroxyvitamin (1α,25(OH)2D3), low. To evaluate mechanism action 1α,25(OH)2D3 skeletal muscle, we examined mitochondrial oxygen consumption, dynamics, biogenesis changes expression nuclear genes encoding proteins human muscle cells following treatment with 1α,25(OH)2D3. The consumption rate (OCR) increased 1α,25(OH)2D3-treated cells. Vitamin...
ABSTRACT Tumor-induced osteomalacia (TIO) is caused by phosphaturic mesenchymal tumors producing fibroblast growth factor 23 (FGF23) and characterized impaired phosphate metabolism, skeletal health, quality of life. UX023T-CL201 an ongoing, open-label, phase 2 study investigating the safety efficacy burosumab, a fully human monoclonal antibody that inhibits FGF23, in adults with TIO or cutaneous hypophosphatemia syndrome (CSHS). Key endpoints were changes serum phosphorus assessed transiliac...
In tumor-induced osteomalacia, a rare syndrome characterized by hypophosphatemia, hyperphosphaturia, low plasma 1,25-dihydroxyvitamin D concentrations, and osteomalacia,1–5 all biochemical pathological abnormalities disappear when the tumor is removed. Tumors associated with this are thought to secrete substance that inhibits renal tubular reabsorption of phosphate,1–5 but whether factor interacts directly cells not known. We investigated ability medium in which sclerosing hemangioma from...
Abstract We report a 4-year randomized, double-blind, placebo-controlled clinical trial in 236 normal postmenopausal women (mean age ± SE, 66.3 0.2 years) who were randomized to calcium (1600 mg/day as the citrate) or placebo group. The seen every 6 months; 177 completed trial. Net percentage changes each group are given relative baseline. differences net (calcium minus group) medians were: for lumbar spine bone density, 2.0% (p < 0.001) at year 1 and 0.3% (not significant) 4;...
Tumors associated with osteomalacia elaborate the novel factor(s), phosphatonin(s), which causes phosphaturia and hypophosphatemia by cAMP-independent pathways. We show that secreted frizzled-related protein-4 (sFRP-4), a protein highly expressed in such tumors, is circulating phosphaturic factor antagonizes renal Wnt-signaling. In cultured opossum epithelial cells, sFRP-4 specifically inhibited sodium-dependent phosphate transport. Infusions of normal rats over 2 hours increased fractional...
1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] is required for normal glucose-stimulated insulin release from pancreatic beta-cells. Biochemical characterization techniques have demonstrated the presence of 1,25(OH)2D3 receptor (VDR) in homogenates whole pancreas. Autoradiographic studies using radiolabeled suggest that VDR localized to beta-cells but are inconclusive. We used immunohistochemical stain serial sections both human and rat pancreas with polyclonal antibodies VDR, chick calbindin D28k,...
Abstract Oncogenic osteomalacia (OOM) is associated with primitive mesenchymal tumors that secrete phosphaturic factors resulting in low serum concentrations of phosphate and calcitriol, phosphaturia, defective bone mineralization. To identify overexpressed genes these tumors, we compared gene expression profiles resected from patients OOM histologically similar control using serial analysis (SAGE). Three hundred sixty-four were expressed at least twofold greater tumors. A subset 67 highly...