A5076699616- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
- Enzyme Structure and Function
- Amino Acid Enzymes and Metabolism
- Neurological diseases and metabolism
- Supramolecular Self-Assembly in Materials
- RNA regulation and disease
- Protein Structure and Dynamics
- Metal-Catalyzed Oxygenation Mechanisms
- Transgenic Plants and Applications
- Hydrogen's biological and therapeutic effects
- Radiopharmaceutical Chemistry and Applications
- Trace Elements in Health
- Bacteriophages and microbial interactions
- CO2 Reduction Techniques and Catalysts
- Parkinson's Disease Mechanisms and Treatments
- Molecular spectroscopy and chirality
- Toxin Mechanisms and Immunotoxins
- Organometallic Complex Synthesis and Catalysis
- Botulinum Toxin and Related Neurological Disorders
- Sulfur Compounds in Biology
- Biopolymer Synthesis and Applications
- Proteins in Food Systems
University of California, Los Angeles
1999-2024
Howard Hughes Medical Institute
2005-2024
University of Copenhagen
2006
European Synchrotron Radiation Facility
2006
Ochanomizu University
2002
Otsuka (Japan)
2002
Oklahoma State University
1996
X-ray diffraction and other biophysical tools reveal features of the atomic structure an amyloid-like crystal. Sup35, a prion-like protein in yeast, forms fibrillar amyloid assemblies intrinsic to its prion function. We have identified polar peptide from N-terminal prion-determining domain Sup35 that exhibits properties full-length including cooperative kinetics aggregation, fibril formation, binding dye Congo red, characteristic cross-beta x-ray pattern. Microcrystals this also share...
A reaction cycle is proposed for the mechanism of copper−zinc superoxide dismutase (CuZnSOD) that involves inner sphere electron transfer from to Cu(II) in one portion and outer Cu(I) other cycle. This based on three yeast CuZnSOD structures determined by X-ray crystallography together with many observations. The new reported here are (1) wild type under 15 atm oxygen pressure, (2) presence azide, (3) His48Cys mutant. Final R-values respectively 20.0%, 17.3%, 20.9%. Comparison these...
Microbial communities are found throughout the biosphere, from human guts to glaciers, soil activated sludge. Understanding statistical properties of such diverse can pave way elucidate common mechanisms ...Multiple ecological forces act together shape composition microbial communities. Phyloecology approaches—which combine phylogenetic relationships between species with community ecology—have potential disentangle but often ...
Amyloid fibrils of tau are increasingly accepted as a cause neuronal death and brain atrophy in Alzheimer's disease (AD). Diminishing aggregation is promising strategy the search for efficacious AD therapeutics. Previously, our laboratory designed six-residue, nonnatural amino acid inhibitor D-TLKIVW peptide (6-DP), which can prevent vitro. However, it cannot block cell-to-cell transmission aggregation. Here, we find D-TLKIVWC (7-DP), d-cysteine extension 6-DP, not only prevents but also...
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LECTURES C8
It was reported that the isomerization reaction from trans-to cis-proline for proteins is enhanced in present of cyclophilin (CyP) A. CyPB with membrane binding signal sequence N-terminal proceeds cis to trans model substrate suc-AAPF-pNA as well CyPA cytoplasm.Suc-APA-pNA, Ac-AAPA-AMC and Suc(Ome)-AAPV-AMC have inhibitory role analogy this reaction.In order ascertain forms complexes intermediates isomerization, we tried crystal analysis these three peptides.Crystallization E. coli did not...