A5101576150- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Cancer Research and Treatments
- Gut microbiota and health
- Immunodeficiency and Autoimmune Disorders
- Esophageal Cancer Research and Treatment
- Pharmacological Effects of Natural Compounds
- Autoimmune and Inflammatory Disorders
- Genetic factors in colorectal cancer
- Neuroendocrine Tumor Research Advances
- Mycobacterium research and diagnosis
- RNA Research and Splicing
- Gastrointestinal Bleeding Diagnosis and Treatment
- Fungal Biology and Applications
- Biosimilars and Bioanalytical Methods
- Tuberculosis Research and Epidemiology
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
Asahikawa Medical University
2015-2025
Weatherford College
2023
International University of Health and Welfare
2015-2019
NEC (Japan)
2002
Pancreatic cancer is associated with a poor prognosis due to challenges in early detection, severe progression of the primary tumor, metastatic lesions, and resistance antitumor agents. However, previous studies have indicated relationship between microbiome pancreatic outcomes. Our study demonstrated that ferrichrome derived from Lactobacillus casei, probiotic bacteria, exhibited tumor‑suppressive effects colorectal gastric cancer, suppressive were stronger than conventional agents, such as...
Abstract Background All Helicobacter pylori -infected patients are recommended for eradication with an appropriate regimen in each geographic area. The choice of the therapy is somewhat dependent on antimicrobial susceptibility. rate clarithromycin resistance has been increasing and associated failure; thus, susceptibility testing before triple clarithromycin. However, not yet clinically available alternative newly developed acid inhibitor vonoprazan used Japan. aim this study was to...
Venous thromboembolism (VTE) is a major extraintestinal manifestation in inflammatory bowel disease (IBD), regarded as an independent risk factor for VTE according to reports from Western countries. However, the incidence and factors of Asian IBD patients are not fully understood. We aimed reveal Japanese inpatients.The inpatients with (n=340), gastrointestinal cancers (n=557), other diseases (n=569) treated at our hospital 2009 2013 was retrospectively investigated. The characteristics...
Abstract Background Colorectal cancers develop through several pathways, including the adenoma–carcinoma sequence and colitis-associated carcinogenesis. An altered intestinal microflora has been reported to be associated with development progression of colorectal cancer via these pathways. We identified Lactobacillus casei -derived ferrichrome as a mediator bacterial anti-tumor effect cells upregulation DDIT3. In this study, we investigated effects on precancerous conditions sporadic well...
Background and study aims Recent advances in cancer treatment have involved the clinical application of immune checkpoint inhibitors (ICIs) for various type cancers. The adverse events associated with ICIs are generally referred to as immune-related (irAEs). Gastrointestinal irAEs a major disorder, but gastritis is not frequently observed. this were elucidate clinical, endoscopic, histological characteristics irAE gastritis. Patients methods Information on patients treated collected from...
To address the challenges of difficult colorectal endoscopic submucosal dissection (ESD), conversion to snare resection (rescue-snare ESD: rSnare), a variant hybrid ESD, is commonly proposed. However, rSnare associated with lower en bloc rate compared conventional ESD. Traction-assisted ESD has emerged as technique facilitate dissection, but its effectiveness rescue method remains unclear. This study was first compare and rescue-traction-assisted (rTraction). retrospective involved 1464...
Inflammatory bowel disease (IBD) significantly impacts employment and work productivity, necessitating support for balancing treatment (SBWT). While SBWT systems have been formalized in Japan, awareness among healthcare professionals remains low. This study aimed to evaluate the effectiveness of an educational program on Hokkaido, Japan. A 2-year questionnaire-based was conducted across eight medical facilities from November 2022 2024. The program, comprising lecture-based self-directed...
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory condition requiring lifelong management, with anti‐tumor necrosis factor α (anti‐TNF‐α) agents often used for refractory cases. However, secondary loss of response (LOR) to these agents, due anti‐drug antibodies, poses significant therapeutic challenge. This report describes case where granulocyte and monocyte adsorptive apheresis (GMA) maintenance therapy successfully restored the efficacy an anti‐TNF‐α agent in 26‐year‐old male...
Inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn's (CD), is an intractable intestinal inflammation associated with the disruption of mucosa. We previously demonstrated that Lactobacillus brevis-derived long-chain polyphosphate (poly P) improved barrier function by upregulation cell adhesion relieved inflammation, thereby exerting a curing effect on in vitro, vivo, investigator-initiated clinical study UC. However, how poly P improves mucosal defects induced has not...
Abstract Intake of probiotics or fermented food produced by some probiotic bacteria is believed to exert anti-tumor functions in various cancers, including pancreatic cancer, because several studies have demonstrated the effects vitro and vivo animal carcinogenesis models. However, mechanisms underlying anticancer on cancer not been clarified. In this study, we assessed against cells. Among known bacteria, Aspergillus oryzae exhibited a strong tumor suppression effect. The culture...
Abstract Background Real-world data regarding ustekinumab (UST) for ulcerative colitis (UC) particularly in biologics-naïve patients is currently limited. This study aimed to elucidate the real-world effectiveness and safety of UST UC. Methods Overall, 150 with UC treated from March 2020 January 2023 were enrolled across 7 referral hospitals. To assess clinical efficacy persistence UST, retrospective analyses conducted weeks 8 56. Predictive factors concerning response examined through...
Esophageal squamous cell carcinoma (ESCC) is often managed with surgery, which the first-line treatment option for stage I-III lesions. However, definitive chemoradiotherapy (dCRT) associated a recurrence rate of 30% in I ESCC and higher rates advanced-staged several patients prefer dCRT because their general condition poor. Salvage therapies, including esophagectomy endoscopic resection [endoscopic submucosal dissection (ESD)/endoscopic mucosal resection], are important residual or...
Multiple myeloma (MM) is a hematological malignancy characterized by poor prognosis. While certain probiotics have been shown to produce antitumor molecules that inhibit solid tumor progression, it remains unclear whether probiotic-derived compounds can exert similar effects on tumors, such as MM. In this study, we screened the cell-free culture supernatants (CFCS) of 24 probiotic strains for against multiple cells and identified CFCS from Clostridium butyricum (C. butyricum) demonstrated...
Abstract RNA regulation mediating RNA-binding proteins (RBPs) have been shown to be related the maintenance of homeostasis as well cancer progression. However, tumor-associated functions detailed mechanisms underlying anti-tumor effects most RBPs yet explored. We herein report that phosphorylated heterogeneous ribonucleoprotein (hnRNP) A0 promotes mitosis through RAS-associated protein 3 GTPase-activating catalytic subunit 1 (RAB3GAP1)-Zeste white 10 interactor (ZWINT1) cascade. The...
The clinical importance of Crohn's disease (CD)-specific lesions in the upper gastrointestinal tract (upper GIT) has not been sufficiently established. aim this case-control study is to investigate characteristic findings CD GIT. In 2740 patients who underwent gastroduodenoscopy at Asahikawa Medical University between April 2011 and December 2012, 81 patients, gender- age-matched non-IBD 66 ulcerative colitis (UC) were investigated present study. (1) diagnostic ability odds ratio each...
The goal of ulcerative colitis (UC) treatment has recently been shown to be "mucosal healing," as no drug directly induces mucosal healing. Probiotics possess sufficient safety, but their efficacy in the UC remains controversial because influence intestinal conditions. It is believed that identification bioactive molecules produced by probiotics and application will help solve this issue. We therefore identified a probiotic-derived long-chain polyphosphate molecule enhancing barrier...
Background: Venous thromboembolism (VTE) has been shown to be more frequent in inflammatory bowel disease (IBD) than the general population Western studies. However, actual state of VTE Asian IBD remains poorly understood. Aims: To reveal incidence patients Japan. Methods: Eighty-five admitted 3 gastroenterology centers were registered from 2013 2018. The with (n = 42) was prospectively compared that among other digestive diseases 43). presence surveyed using contrast-enhanced computed...
The oncogenic properties of heterogeneous nuclear ribonucleoprotein H1 (hnRNP H1) have been reported, although the tumor-promoting mechanism remains unclear. We herein report underlying colorectal cancer cell progression mediated by hnRNP H1. growth cells was suppressed downregulation. A terminal deoxynucleotidyl transferase dUTP nick-end labeling assay revealed anti-apoptotic effect in cells. An RNA immunoprecipitation that bound to sphingosine-1-phosphate lyase 1 (SGPL1). Reverse...
Summary Background The increasing incidence of older‐onset ulcerative colitis (UC), which has a higher risk surgery, is global health issue. However, data regarding intravenous steroid treatment, one the important treatment options to avoid for UC lacking. Aims To evaluate association between onset age and effectiveness steroids in UC. Methods This retrospective multicentre (27 facilities) cohort study included moderate‐to‐severe hospitalised patients who underwent their first April 2014...
Abstract Background Granulocyte and monocyte adsorptive apheresis (GMA) with Adacolumn has been used as a remission induction therapy for patients active ulcerative colitis (UC). Herein, we investigated the influence of concomitant medications in GMA UC. Methods This multicenter retrospective cohort study included UC underwent five independent institutions Japan from January 2011 to July 2021. Factors including associated clinical (CR) were analyzed statistically. Result A total 133...
There have been limited reports on the clinical efficacy of golimumab (GLM) in Japanese patients with ulcerative colitis (UC) real practice. This study aimed to explore real-life effectiveness and factors associated response GLM UC.This observational, retrospective, multicenter was conducted hospitals expertise inflammatory bowel disease treatment. Sixty-three treated active UC were included analysis. Clinical remission (CR) (partial Mayo (pMayo) score ≤2) induction maintenance phases after...
Rationale: Both ulcerative colitis (UC) and sarcoidosis are chronic inflammatory diseases with unknown etiologies rare. However, the odds ratio in UC patients has been reported to range from 1.7 2.1, suggesting a potential etiology between UC. Furthermore, underlying of remain unidentified. Sharing experience patient cardiac could provide valuable insights prevent sudden death patients. Patient concerns: A 71-year-old Japanese woman was diagnosed at 58-year-old maintained remission on...
Summary Background Endoscopic healing (EH) is a therapeutic target in ulcerative colitis (UC). However, even patients who have achieved EH relapse frequently. Aims To investigate the association between recent steroid use and risk UC with EH. Methods This multi‐centre cohort study included 1212 confirmed (Mayo endoscopic subscore ≤1). We excluded current systemic or history of advanced therapy. divided into group (last within 1 year; n = 59) non‐recent steroid‐naïve ( 1153). followed for 2...