A5044909739- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Kidney Injury Research
- Cardiac Arrest and Resuscitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
Hudson Institute of Medical Research
2017-2021
Monash University
2017-2021
Monash Institute of Medical Research
2019
Monash Medical Centre
2017
Umbilical cord milking (UCM) at birth may benefit preterm infants, but the physiological effects of UCM are unknown. We compared two strategies with immediate umbilical clamping (UCC) and physiological-based (PBCC) in lambs.At 126 days' gestational age, fetal lambs were exteriorised, intubated instrumented to measure umbilical, pulmonary cerebral blood flows arterial pressures. Lambs received either (1) without placental refill (UCMwoPR); (2) (UCMwPR); (3) PBCC, whereby ventilation commenced...
Acute Kidney Injury (AKI) is a well recognized complication of cardiac surgery. It associated with significant morbidity and mortality. The aims our study are twofold; We prospectively studied 196 consecutive patients undergoing elective (on-pump) Baseline patient characteristics, including medical co-morbidities, proteinuria, procedural data kidney function (serum creatinine (sCr) were collected. Internationally standardised criteria for AKI used (sCr >1.5 times baseline, elevation in sCr...
Placental transfusion has been thought to be the main benefit of delayed umbilical cord clamping (DCC) in preterm neonates. However, importance cardiovascular stability provided by allowing lung aeration prior recently highlighted. We aimed determine influence blood volume changes on at birth. Preterm lambs (0.85 gestation) were instrumented for measurement pulmonary, systemic and cerebral pressures flows, oxygen saturation oxygenation. Left ventricular output (LVO) was assessed Doppler...
Background Delayed umbilical cord clamping (UCC) after birth is thought to cause placental infant blood transfusion, but the mechanisms are unknown. It has been suggested that uterine contractions force out of placenta and into during delayed clamping. We have investigated effect contractions, induced by maternal oxytocin administration, on artery (UA) venous (UV) flows before ventilation onset determine whether transfusion in preterm lambs. Methods findings At ~128 days gestation, UA UV...