Magnetic resonance imaging (MRI) of the knee is often performed in patients who have symptoms unclear cause. When meniscal tears are found, it commonly assumed that attributable to them. However, there a paucity data regarding prevalence damage general population and association with radiographic evidence osteoarthritis.

Knee osteoarthritis (OA) is highly prevalent, especially in the elderly. Preventive strategies require a knowledge of risk factors that precede disease onset. The present study was conducted to determine longitudinal for knee OA an elderly population.A involving members Framingham Study cohort performed. Weight-bearing radiographs were obtained 1983-1985 (baseline) and again 1992-1993. Incident defined as occurrence new radiographic (Kellgren Lawrence grade > or = 2 on 0-4 scale) those...

Abstract Objective . To determine the incidence of radiographic knee osteoarthritis (OA) and symptomatic OA (symptoms plus OA), as well rate progression preexisting in a population‐based sample elderly persons. Methods Framingham Osteoarthritis Study subjects who had radiographs answered questions about symptoms 1983–1985 were reexamined 1992–1993 (mean 8.1‐year interval) using same protocol. Subjects defined having new (incident) if they developed grade ≤2 (at least definite osteophytes or...

Abstract Objective Results of cross‐sectional studies have suggested that bone marrow lesions (BMLs) visualized on magnetic resonance imaging (MRI) are related to knee pain, but no longitudinal been done. This study was undertaken determine whether enlarging BMLs associated with new pain. Methods Subjects ages 50–79 years osteoarthritis (OA) or at high risk OA were asked twice baseline about the presence aching, stiffness (classified as frequent pain) most days; absence pain eligibility...

<b>Objective</b> To examine the relation of radiographic features osteoarthritis to knee pain in people with knees discordant for two cohorts. <b>Design</b> Within person, matched, case-control study. <b>Setting and participants</b> Participants Multicenter Osteoarthritis (MOST) Framingham studies who had radiographs assessments pain. <b>Main outcome measures</b> Association each measure (frequency, consistency, severity) osteoarthritis, as assessed by Kellgren Lawrence grade (0-4)...

Abstract Objective Although partial meniscectomy is a risk factor for the development of knee osteoarthritis (OA), there lack evidence that meniscal damage not treated with surgery would also lead to OA, suggesting itself may cause joint damage. Furthermore, common. The aim this study was evaluate association between in knees without and radiographic tibiofemoral OA. Methods We conducted prospective case–control nested within observational Multicenter Osteoarthritis Study, which included...

To estimate the prevalence of radiographic and symptomatic knee osteoarthritis (OA) in a population-based sample elderly subjects Beijing, China compare it with that reported Framingham (Massachusetts) OA Study.We recruited persons age > or = 60, using door-to-door enumeration randomly selected neighborhoods Beijing. Subjects completed home interview including questions on symptoms hospital examination radiographs obtained during weight bearing. The protocol was identical to used Study. A...

Abstract Objective . Cumulative damage to tissues, mediated by reactive oxygen species, has been implicated as a pathway that leads many of the degenerative changes associated with aging. We hypothesized increased intake antioxidant micronutrients might be decreased rates osteoarthritis (OA) in knees, common age‐related disorder. Methods Participants Framingham Osteoarthritis Cohort Study underwent knee evaluations radiography at examinations 18 (1983–1985) and 22 (1992–1993). Usual dietary...

PURPOSE: Because osteoarthritis may be caused by "wear and tear," we examined the association between level of physical activity risk knee in elderly.SUBJECTS AND METHODS: Eligible subjects were participants Framingham Heart Study cohort who had radiographically normal knees at biennial exam 18 (1983–1985) also completed a questionnaire 20 (1988–1989). Follow-up radiographs obtained 22 (1992–1993). The study outcomes development incident radiographic or symptomatic baseline follow-up...

Abstract Objective To examine whether obesity increases the risk of progression knee osteoarthritis (OA). Methods We used data from Multicenter Osteoarthritis Study, a longitudinal study persons with or at high OA. OA was characterized baseline and 30 months using posteroanterior fixed‐flexion radiographs Kellgren/Lawrence (K/L) grading, alignment assessed on full‐extremity films. In knees (K/L grade 2 3), defined as tibiofemoral joint space narrowing 30‐month radiograph. without 0 1),...

To confirm reports that 25-hydroxyvitamin D (25[OH]D) deficiency is associated with an increased risk of joint space narrowing or cartilage loss in osteoarthritis (OA).We measured 25(OH)D levels subjects from 2 longitudinal cohort studies, the Framingham Osteoarthritis Study and Boston Knee (BOKS). In first, weight-bearing anteroposterior (AP) lateral knee radiographs were obtained on 1993-1994 again 2002-2005 (mean interval 9 years); blood was drawn for measurement vitamin status 1996-2000....

Abstract Objective Weakness has been documented as a feature of tibiofemoral knee osteoarthritis (OA) and may cause disease in this compartment by shock absorption during impulse loading at heel strike, when the patellofemoral joint is not engaged. Our objective was to determine association muscle weakness with compartment‐specific OA, evaluate sex‐specific differences relationship, determine, evaluating asymptomatic individuals whether symptoms produce seen OA. Methods This cross‐sectional...

This study reports findings on joint fluid enhancement after intravenous administration of gadopentetate dimeglumine. Ten subjects were studied: two asymptomatic volunteers and eight patients with suspected meniscal tears. The underwent imaging at 1.5 T before, immediately after, 42-60 minutes rate was assessed in three subjects, the effects exercise studied. All exhibited fluid. Mean for 137% initial 262% delayed images obtained exercise. Exercise increased degree distributed contrast...

Abstract Objective To evaluate the long‐term effect of recreational exercise on development knee osteoarthritis (OA) in a community‐based cohort older adults, many whom were overweight or obese. Methods Subjects asked about activities including walking jogging for and working up sweat, to compare their activity levels with others. then pain weight‐bearing anteroposterior lateral radiographs obtained. Approximately 9 years later, subjects reexamined OA. Radiographs read OA features both...

Background: Knee buckling is common in persons with advanced knee osteoarthritis and after orthopedic procedures. Its prevalence the community unknown. Objective: To examine of community, its associated risk factors, relation to functional limitation. Design: Cross-sectional, population-based study. Setting: The Framingham Osteoarthritis Study. Participants: 2351 men women age 36 94 years (median, 63.5 years). Measurements: Participants were asked whether they had experienced or "giving way"...

Previous studies have suggested that metabolic syndrome is associated with osteoarthritis (OA). However, analyses often not included adjustment for body mass index (BMI) and addressed whether levels of individual components are related to OA. This study was undertaken examine the relationship its radiographic symptomatic knee OA.Framingham Study subjects were assessed OA in 1992-1995 again 2002-2005. Near baseline visit, had assessed. We defined incident as present when a without at...

Abstract Objective Poor intake of vitamin K is common. Insufficient can result in abnormal cartilage and bone mineralization. Furthermore, osteophyte growth, seen osteoarthritis (OA), may be a K–dependent process. We undertook this study to determine whether deficiency associated with radiographic features OA. Methods conducted an analysis among 672 participants (mean age 65.6 years, 358 women) the Framingham Offspring Study, population‐based prospective observational cohort. Levels plasma...

Abstract Objective To examine the relationship of knee malalignment to occurrence osteoarthritis (OA) among subjects without radiographic OA at baseline determine whether is a risk factor for incident disease or simply marker increasing severity. Methods We selected 110 tibiofemoral (TF) case knees (76 subjects) and 356 random control (178 from participants in Framingham Osteoarthritis Study. Case did not have (1992–1994 examination) but had developed (Kellgren/Lawrence grade ≥2) followup...

Objectives To test whether knees which recently developed disease were at higher risk for subsequent x-ray progression than had been stable, suggesting that recent change produces further and stability yields (a pattern of inertia). Methods We used central readings the annual posteroanterior x-rays obtained in Osteoarthritis Initiative (OAI) focusing on Kellgren Lawrence (KL) grade semiquantitative joint space. examined incident (KL 2) already 2 stable disease. combined data from multiple...

Abstract Objective We recently reported that, despite their thinness, elderly subjects in Beijing, China had an equal prevalence (in men) or higher women) of both radiographic and symptomatic knee osteoarthritis (OA) compared with that the Framingham, Massachusetts cohort subjects. Our objective was to evaluate whether Chinese might have more medial disease than do Caucasians, given a report varus alignment joints elderly. Methods lateral OA measured anatomic knees from Beijing Framingham...

To determine in the knee which individual radiographic feature or combination of features patellofemoral and tibiofemoral joints correlate best with a nonradiographic definition clinical osteoarthritis order to recommend for use studies.Using data from Framingham Osteoarthritis Study, we tested correlation OA, defined as frequent pain plus crepitus, variety definitions OA including those based on features, e.g. > = grade 2 osteophyte 0-3 scale, new that included alternative combinations...

Abstract Objective To examine the association between squatting, a common daily posture in China, and prevalence of radiographic osteoarthritis (OA) different knee compartments among Chinese subjects from Beijing, to estimate how much difference OA Beijing white Framingham, Massachusetts is accounted for by impact squatting. Methods We recruited random sample residents age ≥60 years. Subjects answered questions on joint symptoms, radiographs were obtained. also asked recall average amount...

Abstract Objective Fewer Chinese subjects in Beijing have hip osteoarthritis (OA) compared with whites the United States, but as many or more knee OA. If these differences are due to a systemic predilection for disease, then prevalence of hand OA, best indicator generalized should be different China. The goals this study were estimate OA among elderly Beijing, and compare it that States. Methods We recruited random sample residents ages ≥60 years. Subjects answered questions on joint...