A5056441339- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Cancer-related cognitive impairment studies
- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Bone health and treatments
- Enzyme function and inhibition
- Advances in Oncology and Radiotherapy
- Radiation Dose and Imaging
- Breast Cancer Treatment Studies
- Atomic and Subatomic Physics Research
- Advanced X-ray and CT Imaging
- Organophosphorus compounds synthesis
- Nuclear Physics and Applications
- Boron Compounds in Chemistry
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Radiation Effects and Dosimetry
- Synthesis and biological activity
- Radiomics and Machine Learning in Medical Imaging
- Advanced Measurement and Metrology Techniques
- Economic and Financial Impacts of Cancer
New York Proton Center
2021-2024
Chung Shan Medical University Hospital
2023
University of Florida
2019-2020
Florida College
2019
Chang Gung Memorial Hospital
2011-2016
Chang Gung University
2015-2016
Taoyuan Chang Gung Memorial Hospital
2011
Memorial Sloan Kettering Cancer Center
2011
Monmouth Medical Center
2006
Whole brain radiotherapy (WBRT) has been the treatment of choice for patients with metastases. However, change/decline neurocognitive functions (NCFs) resulting from impaired hippocampal neurogenesis might occur after WBRT. It is reported that conformal sparing would provide preservation NCFs. Our study aims to investigate dosimetry and demonstrate correlation between outcomes in receiving during WBRT (HS-WBRT). Forty prospectively recruited cancer underwent HS-WBRT therapeutic or...
Experimental measurements of two-dimensional (2D) dose rate distributions in proton pencil beam scanning (PBS) FLASH radiation therapy (RT) are currently lacking. In this study, we characterize a newly designed 2D strip-segmented ionization chamber array (SICA) with high spatial and temporal resolution demonstrate its applications modern PBS delivery system at both conventional ultrahigh rates.A dedicated research beamline the Varian ProBeam was employed to deliver 250-MeV nozzle currents up...
Abstract Background The potential reduction of normal tissue toxicities during FLASH radiotherapy (FLASH‐RT) has inspired many efforts to investigate its underlying mechanism and translate it into the clinic. Such investigations require experimental platforms FLASH‐RT capabilities. Purpose To commission characterize a 250 MeV proton research beamline with saturated nozzle monitor ionization chamber for small animal experiments. Methods A 2D strip array (SICA) high spatiotemporal resolution...
The purpose of this study was to assess the feasibility using a multiple partial volumetric‐modulated arcs therapy (MP‐VMAT) technique on left breast irradiation and evaluate dosimetry treatment efficiency. Ten patients with left‐sided cancer who had been treated by whole were selected for plan evaluation six volumetric modulated arcs. Each arc consisted 50° gantry rotation. planning target volumes normal organs, including right breast, bilateral lungs, ventricle, heart, unspecified tissue,...
Abstract
Abstract Objective . To investigate the effects of respiratory motion on delivered dose in context proton pencil beam scanning (PBS) transmission FLASH radiotherapy (FLASH-RT) by simulation and phantom measurements. Approach An in-house code was employed to perform silico 2D distributions for clinically relevant PBS FLASH-RT treatments. A moving grid introduced impacts various treatment delivery parameters dynamic delivery. strip-ionization chamber array detector an IROC platform were...
Abstract Background Several studies have shown pencil beam scanning (PBS) proton therapy is a feasible and safe modality to deliver conformal ultra‐high dose rate (UHDR) FLASH radiation therapy. However, it would be challenging burdensome conduct the quality assurance (QA) of along with conventional patient‐specific QA (psQA). Purpose To demonstrate novel measurement‐based psQA program for UHDR PBS transmission radiotherapy (FLASH‐RT) using high spatiotemporal resolution 2D strip ionization...
Purpose: The study evaluates the efficacy of cone-beam computed tomography (CBCT)-based synthetic CTs (sCT) as a potential alternative to verification CT (vCT) for enhanced treatment monitoring and early adaptation in proton therapy. Methods: Seven common sites were studied. Two sets sCT per case generated: direct-deformed (DD) image-correction (IC) sCT. image qualities dosimetric impact compared same-day vCT. Results: agreed with vCT regions homogeneous tissues such brain breast; however,...
Abstract Background Quality assurance (QA) for ultra‐high dose rate (UHDR) irradiation is a crucial aspect in the emerging field of FLASH radiotherapy (FLASH‐RT). This innovative treatment approach delivers radiation at UHDR, demanding careful adoption QA protocols and procedures. A comprehensive understanding beam properties dosimetry consistency vital to ensure safe effective delivery FLASH‐RT. Purpose To develop pre‐treatment program cyclotron‐based proton pencil scanning (PBS) Establish...
Purpose To evaluate organ at risk (OAR) auto-segmentation in the head and neck region of computed tomography images using two different commercially available deep-learning-based (DLAS) tools a single institutional clinical applications. Methods Twenty-two OARs were manually contoured by clinicians according to published guidelines on planning (pCT) for 40 cancer (HNC) cases. Automatic contours generated each patient models—Manteia AccuContour MIM ProtégéAI. The accuracy integrity...
Traditionally, the treatment couch coordinates (TCCs) for patients undergoing radiotherapy can only be determined at time of treatment, placing pressure on treating therapists and leaving several pathways errors such as wrong-site or wrong table shift from a reference point. The purpose this work is to propose an accurate, robust, streamlined system that calculates TCC in advance.The proposed combines advantages two different calculation methods use indexed immobilization device. first...
Purpose Directly extracting the respiratory phase pattern of tumor using cone‐beam computed tomography (CBCT) projections is challenging due to poor visibility caused by obstruction multiple anatomic structures on beam's eye view. Predicting information external surrogate also has intrinsic difficulties as patterns between surrogates and tumors are not necessary be congruent. In this work, we developed an algorithm accurately recover primary oscillation components motion combined from both...
Dose perturbation of spot-scanning proton beams passing through a dislocated metallic port (MP) breast tissue expander may degrade target dose coverage or deliver excess to the ipsilateral lung and heart. The feasibility utilizing daily cone-beam computed tomography (CBCT)-based synthetic CTs (synCTs) for reconstruction was evaluated, fractional cumulative dosimetric impact due MP dislocation is reported.The synCT generated by deforming simulation CT CBCT. structure template mapped onto all...
Purpose: Patient specific QA, one of important QA in radiotherapy, was performed with different devices hospitals. It commonly conducted 2D array devices. To quickly and accurately verify 3D dose delivered is a big issue clinic. The aim this study to validate the COMPASS system for verification rotational conventional IMRT technique as part our clinical RapidArc program. Methods: Several cases treatment sites were chosen study. Each case measured MatriXX mounted on gantry reconstruct...
Purpose: In this study, we present an effective method to derive low dose envelope of the proton in‐air spot fluence at beam positions other than isocenter reduce amount measurements required for planning commission. Also, demonstrate commissioning and validation results Eclipse treatment system (version 13.0.29) a Sumitomo dedicated line scanning nozzle. Methods: The profiles five beam‐axis (±200, ±100 0 mm) were obtained in trigger mode using MP3 Water tank (PTW‐Freiburg) pinpoint...
Purpose: The evaluation of using RapidPlan to generate the model simultaneous integrated boost (SIB) VMAT plans for nasopharyngeal carcinoma (NPC). Methods: In this study, training models were established SIB NPC cases in RadpidPlan system. knowledge database was created from 46 with two dose level targets. CTV212 received 69.96 Gy 33 fractions at 2.12 per fraction. PTV164 54.12 1.64 To validate models, we generated model-estimated objectives on four new that not included model-training...