A5049412919- Atherosclerosis and Cardiovascular Diseases
- Single-cell and spatial transcriptomics
- Adipokines, Inflammation, and Metabolic Diseases
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Cardiac Imaging and Diagnostics
- Tissue Engineering and Regenerative Medicine
University of British Columbia
2021-2025
University of British Columbia Hospital
2024
Technion – Israel Institute of Technology
2019
De-differentiation and activation of pro-inflammatory pathways are key transitions vascular smooth muscle cells (SMCs) make during atherogenesis. Here, we explored the upstream regulators this 'atherogenic transition'.
Diffuse intimal thickening (DIT) is a pre-clinical stage of atherosclerosis characterized by thickened intima. The molecular basis its susceptibility to atherogenesis unknown, and mechanistic investigations cannot be performed in commonly used mouse models, which DIT does not exist. Vascular smooth muscle cells (SMCs) are the predominant cell type that occupies intima media DIT. differences between these two layers may reveal earliest phenotypic changes SMCs promote atherosclerosis. We...
Background: Diffuse intimal thickening (DIT) is a pre-clinical stage of atherosclerosis characterized by thickened intima. The molecular basis its susceptibility to atherogenesis unknown, and mechanistic investigations cannot be performed in commonly used mouse models, which DIT does not exist. Vascular smooth muscle cells (SMCs) are the predominant cell type that occupies intima media DIT. differences between these two layers may reveal earliest phenotypic changes SMCs promote...
Diffuse intimal thickening (DIT) is a pre-clinical stage of atherosclerosis characterized by thickened intima. The molecular basis its susceptibility to atherogenesis unknown, and mechanistic investigations cannot be performed in commonly used mouse models, which DIT does not exist. Vascular smooth muscle cells (SMCs) are the predominant cell type that occupies intima media DIT. differences between these two layers may reveal earliest phenotypic changes SMCs promote atherosclerosis. We...
Engineering of functional tissue, by combining either autologous or allogeneic cells with biomaterials, holds promise for the treatment various diseases and injuries. Prevascularization engineered tissue was shown to enhance improve graft integration neovascularization post-implantation in immunocompromised mice. However, processes transplanted tissues have not been widely studied immunocompetent models. Here, we fabricated a three-dimensional (3D) vascularized murine muscle construct that...
Background Previous studies using animal models and cultured cells suggest that vascular smooth muscle (SMCs) inflammatory cytokines are important players in atherogenesis. Validating these findings human disease is critical to designing therapeutics target components. Multiplex imaging a powerful tool for characterizing cell phenotypes microenvironments biobanked tissue sections. However, this technology has not been applied atherosclerotic lesions needs first be customized validated....
Background: In the past few years, animal models and cultured cells have shown that smooth muscle (SMCs) inflammatory cytokines are important new players in atherosclerotic disease. Validating roles of these human atherogenesis is crucial for development therapeutics targeting them. Multiplex imaging a powerful tool mapping cell phenotypes microenvironment tissue sections, enabling proof-of-concept studies using biobanked specimens. However, this technology has seldom been applied to...